Publications by authors named "Ulriche Denis"
Biochim Biophys Acta
August 2004
Article Synopsis
- Apoptosis, or programmed cell death, is likely the reason pericytes (a type of cell in the eye) are lost in diabetic retinopathy, a common eye problem for people with diabetes.
- In the study, scientists found that a substance called AGE-MGX causes pericytes to die by triggering certain biochemical changes in the cells.
- They discovered that caspases (special proteins that help the death process) play different roles, especially caspase-10, which could be a target for new treatments to help prevent eye damage in people with diabetes.
Free Radic Biol Med
July 2002
Article Synopsis
- Diabetic retinopathy starts with the loss of special cells in the eyes called pericytes, which protect tiny blood vessels.
- A study found that a substance called AGE can make these pericytes die by causing a cell process called apoptosis, and this is linked to increased levels of certain molecules called ceramide and diacylglycerol.
- Using antioxidants can stop this cell death, suggesting that it’s caused by stress in the cells, and researchers discovered new ways to target this problem for better treatments in diabetic retinopathy.
