Publications by authors named "Ulrich Walliser"

In adults the healing tendon generates fibrovascular scar tissue and recovers never histologically, mechanically, and functionally which leads to chronic and to degenerative diseases. In this review, the processes and mechanisms of tendon development and fetal regeneration in comparison to adult defect repair and degeneration are discussed in relation to regenerative therapeutic options. We focused on the application of stem cells, growth factors, transcription factors, and gene therapy in tendon injury therapies in order to intervene the scarring process and to induce functional regeneration of the lesioned tissue.

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Article Synopsis
  • Adipose tissue-derived mesenchymal stromal cells (AT-MSCs) are used to treat tendon injuries in horses, but little is known about what happens to them after injection into the tendons.
  • In a study involving four horses, researchers injected autologous AT-MSCs labelled with special particles and monitored their presence using MRI and histological techniques over a period of 3 to 9 weeks.
  • Results showed that the AT-MSCs could be tracked via MRI and were still present in the tendons in significant amounts at the end of the study, indicating this method could be a viable option for monitoring treatment efficacy.
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Background: The benefit of pre and post-operative administration of non-steroidal anti-inflammatory drugs for the relief of post-operative pain and control of inflammation in horses following orthopaedic surgery has not been previously investigated in controlled clinical field trials, and the utility of such treatment is a matter of ongoing dispute. Recently the utility of post-operative pain management was emphasized. It was therefore our aim to determine the efficacy of meloxicam in horses following partial resection of fractured splint bones.

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Objective: To evaluate the proliferative behavior, telomere length, immunophenotype, and differentiation capacity of equine adipose tissue-derived mesenchymal stem cells (AT-MSCs).

Animals: 6 adult racing horses treated for articular Injury but otherwise healthy.

Procedures: AT-MSCs were Isolated from horses and expanded In Dulbecco modified Eagle medium enriched with fetal bovine serum and antimicrobials.

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