Publications by authors named "Ulrich Vasconcelos"
The pequi () is a typical fruit from the Brazilian Cerrado. From it, pequi pulp oil is extracted, a valuable product for cosmetic applications due to its high levels of unsaturated fatty acids and carotenoids. Carotenoids are antioxidant compounds that are easily oxidized.
View Article and Find Full Text PDFEvaluation of (-)-Fenchone antimicrobial activity against oral Candida albicans and toxicological parameters: an in silico, in vitro and ex vivo study.
An Acad Bras Cienc
November 2024
Article Synopsis
- - Candida albicans is the main cause of oral candidiasis, and its growing resistance to drugs has sparked the search for better antifungal treatments, leading researchers to investigate the effects of (-)-fenchone.
- - The study found that (-)-fenchone is effective against C. albicans, including strains resistant to miconazole, demonstrating strong antifungal properties with a Minimum Inhibitory Concentration (MIC) of 8 μg/mL.
- - Negative effects on the fungus do not stem from cell wall or membrane damage, and although (-)-fenchone has some ability to prevent biofilm formation, it doesn't disrupt existing biofilms; it also showed low toxicity, suggesting it could be a viable treatment
This is the first study that describes the antifungal and anti-biofilm potential of O-alkylamidoximes against strains of Cryptococcus neoformans and Cryptococcus gattii. In vitro tests have shown that O-alkylamidoximes are capable of inhibiting fungal growth and biofilm formation of the C. neoformans and C.
View Article and Find Full Text PDFPatulin (PAT) is a natural product isolated from several species of fungi. Here, we evaluated the effect of PAT (62.5-4,000 ng/ml) in lipopolysaccharide (LPS)-activated murine peritoneal macrophages.
View Article and Find Full Text PDFPurpose: Certain ocular resident or pathogenic microbes may remain viable in the presence of multi-purpose disinfectant solutions (MPDSs), subsequently developing biofilms inside contact lens storage cases (CLSCs) which pose a risk of infection to wearers. This study evaluated the formation of ocular microbiota biofilms exposed to three top selling MPDS.
Methods: Crystal violet assay was carried out for the verification of biofilm formation.
Pyocyanin was the first natural phenazine described. The molecule is synthesized by about 95% of the strains of From discovery up to now, pyocyanin has been characterised by a very rich and avant-garde history, which includes its use in antimicrobial therapy, even before the discovery of penicillin opened the era of antibiotic therapy, as well as its use in electric current generation. Exhibiting an exuberant blue colour and being easy to obtain, this pigment is the subject of the present review, aiming to narrate its history as well as to unveil its mechanisms and suggest new horizons for applications in different areas of engineering, biology and biotechnology.
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