The Late Orchid Catches the Bee: Frost Damage and Pollination Success in the Face of Global Warming in a European Terrestrial Orchid.

Global warming changes flowering times of many plant species, with potential impacts on frost damage and their synchronization with pollinator activity. These effects can have severe impacts on plant fitness, yet we know little about how frequently they occur and the extent of damage they cause. We addressed this topic in a thermophilic orchid with a highly specific pollination mechanism, the Small Spider Orchid, RchB, in six populations in Northern Switzerland.

Heart rate variability in pulmonary vascular disease at altitude: a randomised trial.

Background: Hypoxia is a trigger for sympathetic activation and autonomic cardiovascular dysfunction. Pulmonary vascular disease (PVD) is associated with hypoxaemia, which increases with altitude. The aim was to investigate how exposure of patients with PVD to hypobaric hypoxia at altitude affects autonomic cardiovascular regulation.

Run-time motion and first-order shim control by expanded servo navigation.

Purpose: To provide a navigator-based run-time motion and first-order field correction for three-dimensional human brain imaging with high precision, minimal calibration and acquisition, and fast processing.

Methods: A complex-valued linear perturbation model with feedback control is extended to estimate and correct for gradient shim fields using orbital navigators (2.3 ms).

SARS-CoV-2 Transmission during High-Altitude Field Studies.

Grimm, Mirjam, Lucie Ziegler, Annina Seglias, Maamed Mademilov, Kamila Magdieva, Gulzada Mirzalieva, Aijan Taalaibekova, Simone Suter, Simon R. Schneider, Fiona Zoller, Vera Bissig, Lukas Reinhard, Meret Bauer, Julian Müller, Tanja L. Ulrich, Arcangelo F.

The effect of high altitude (2500 m) on incremental cycling exercise in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: a randomised controlled crossover trial.

Background: Our objective was to investigate the effect of a day-long exposure to high altitude on peak exercise capacity and safety in stable patients with pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH).

Methods: In a randomised controlled crossover trial, stable patients with PAH or distal CTEPH without resting hypoxaemia at low altitude performed two incremental exercise tests to exhaustion: one after 3-5 h at high altitude (2500 m) and one at low altitude (470 m).

Results: In 27 patients with PAH/CTEPH (44% females, mean±sd age 62±14 years), maximal work rate was 110±64 W at 2500 m and 123±64 W at 470 m (-11%, 95% CI -16- -11%; p<0.

Servo navigators: Linear regression and feedback control for rigid-body motion correction.

Purpose: Navigator-based correction of rigid-body motion reconciling high precision with minimal acquisition, minimal calibration and simple, fast processing.

Methods: A short orbital navigator (2.3 ms) is inserted in a three-dimensional (3D) gradient echo sequence for human head imaging.

Visual Style Elements in Human-System Interface Design for Nuclear Power Operations: Does Style Affect Performance and Preference?

Objective: As the world increasingly adopts renewable and sustainable energy systems, transitionary solutions include nuclear power, which currently provides 20% of the United States' electricity and is the largest single source of carbon-free electricity generation. Advanced reactors are a critical component of a carbon-free mixed energy portfolio that require careful design of first-of-a-kind control rooms.

Background: The application of Human Factors Engineering (HFE) is essential for scientific and iterative testing of novel human-system interface (HSI) concepts to ensure effective, efficient, and safe plant operations.

The complex dynamics of the 2023 Kahramanmaraş, Turkey, 7.8-7.7 earthquake doublet.

The destructive 2023 moment magnitude () 7.8-7.7 earthquake doublet ruptured multiple segments of the East Anatolian Fault system in Turkey.

Uptake of Hydrogen Peroxide from the Gas Phase to Grain Boundaries: A Source in Snow and Ice.

Hydrogen peroxide is a primary atmospheric oxidant significant in terminating gas-phase chemistry and sulfate formation in the condensed phase. Laboratory experiments have shown an unexpected oxidation acceleration by hydrogen peroxide in grain boundaries. While grain boundaries are frequent in natural snow and ice and are known to host impurities, it remains unclear how and to which extent hydrogen peroxide enters this reservoir.

Dynamics, interactions and delays of the 2019 Ridgecrest rupture sequence.

The observational difficulties and the complexity of earthquake physics have rendered seismic hazard assessment largely empirical. Despite increasingly high-quality geodetic, seismic and field observations, data-driven earthquake imaging yields stark differences and physics-based models explaining all observed dynamic complexities are elusive. Here we present data-assimilated three-dimensional dynamic rupture models of California's biggest earthquakes in more than 20 years: the moment magnitude (M) 6.

Dueling dynamics of low-angle normal fault rupture with splay faulting and off-fault damage.

Despite a lack of modern large earthquakes on shallowly dipping normal faults, Holocene M> 7 low-angle normal fault (LANF; dip<30°) ruptures are preserved paleoseismically and inferred from historical earthquake and tsunami accounts. Even in well-recorded megathrust earthquakes, the effects of non-linear off-fault plasticity and dynamically reactivated splay faults on shallow deformation and surface displacements, and thus hazard, remain elusive. We develop data-constrained 3D dynamic rupture models of the active Mai'iu LANF that highlight how multiple dynamic shallow deformation mechanisms compete during large LANF earthquakes.

Hypoxia-altitude simulation test to predict altitude-related adverse health effects in COPD patients.

Background/aims: Amongst numerous travellers to high altitude (HA) are many with the highly prevalent COPD, who are at particular risk for altitude-related adverse health effects (ARAHE). We then investigated the hypoxia-altitude simulation test (HAST) to predict ARAHE in COPD patients travelling to altitude.

Methods: This prospective diagnostic accuracy study included 75 COPD patients: 40 women, age 58±9 years, forced expiratory volume in 1 s (FEV) 40-80% pred, oxygen saturation measured by pulse oximetry ( ) ≥92% and arterial carbon dioxide tension ( ) <6 kPa.

Validation of Noninvasive Assessment of Pulmonary Gas Exchange in Patients with Chronic Obstructive Pulmonary Disease during Initial Exposure to High Altitude.

Investigation of pulmonary gas exchange efficacy usually requires arterial blood gas analysis (aBGA) to determine arterial partial pressure of oxygen (mPaO) and compute the Riley alveolar-to-arterial oxygen difference (A-aDO); that is a demanding and invasive procedure. A noninvasive approach (AGM100), allowing the calculation of PaO (cPaO) derived from pulse oximetry (SpO), has been developed, but this has not been validated in a large cohort of chronic obstructive pulmonary disease (COPD) patients. Our aim was to conduct a validation study of the AG100 in hypoxemic moderate-to-severe COPD.

Super-resolution within a one-dimensional phononic crystal of resonators using time reversal in an equivalent circuit model.

An equivalent circuit model has been developed to model a one-dimensional waveguide with many side-branch Helmholtz resonators. This waveguide constitutes a phononic crystal that has been shown to have decreased phase speed below the resonance frequency of an individual resonator. This decreased phase speed can be exploited to achieve super-resolution using broadband time reversal focusing techniques.

Assessing Margin-Wide Rupture Behaviors Along the Cascadia Megathrust With 3-D Dynamic Rupture Simulations.

From California to British Columbia, the Pacific Northwest coast bears an omnipresent earthquake and tsunami hazard from the Cascadia subduction zone. Multiple lines of evidence suggests that magnitude eight and greater megathrust earthquakes have occurred - the most recent being 321 years ago (i.e.

Finite-element-based resonant ultrasound spectroscopy for measurement of multi-material samples.

Understanding the elastic properties of materials is critical for their safe incorporation and predictable performance. Current methods of bulk elastic characterization often have notable limitations for in situ structural applications, with usage restricted to simple geometries and material distributions. To address these existing issues, this study sought to expand the capabilities of resonant ultrasound spectroscopy (RUS), an established nondestructive evaluation method, to include the characterization of isotropic multi-material samples.

Exploring 3D elastic-wave scattering at interfaces using high-resolution phased-array system.

The elastic-wave scattering at interfaces, such as cracks, is essential for nondestructive inspections, and hence, understanding the phenomenon is crucial. However, the elastic-wave scattering at cracks is very complex in three dimensions since microscopic asperities of crack faces can be multiple scattering sources. We propose a method for exploring 3D elastic-wave scattering based on our previously developed high-resolution 3D phased-array system, the piezoelectric and laser ultrasonic system (PLUS).

From force chains to nonclassical nonlinear dynamics in cemented granular materials.

In this letter, we present evidence for a mechanism responsible for the nonclassical nonlinear dynamics observed in many cemented granular materials that are generally classified as mesoscopic nonlinear elastic materials. We demonstrate numerically that force chains are created within the complex grain-pore network of these materials when subjected to dynamic loading. The interface properties between grains along with the sharp and localized increase of the stress occurring at the grain-grain contacts leads to a reversible decrease of the elastic properties at macroscopic scale and peculiar effects on the propagation of elastic waves when grain boundary properties are appropriately considered.

Flight attendant occupational nutrition and lifestyle factors associated with COVID-19 incidence.

In the era of COVID-19, essential workers are plagued with unforeseen and obfuscated challenges. Flight attendants are a unique subgroup of essential workers who face a multitude of health risks attributed to occupational exposures that are accentuated by the COVID-19 pandemic. Such risks can be ameliorated with strategies that target factors which enhance COVID-19 risk, including modifiable factors of diet and lifestyle.

The Evolving Role of Public Health in Medical Education.

Medical education in the twentieth century was largely influenced by the Flexner Report, with significant proportions of instruction dedicated to the molecular underpinnings of the pathologic pathways and minimal mention of the socio-ecological determinants of health. When examining the predominant diseases of the twenty first century landscape, widening health disparities, and significant changes in the United States healthcare system, it is imperative to view wellness and sickness in a broader public health context rather than a singular focus of the biomedical model. While undergraduate opportunities to study public health are on the rise in the United States, there is a parallel urgency for medical curricula to recognize the importance of the complex interrelated socio-ecological root causes of health, well-being, and illness.

Dynamic viability of the 2016 Mw 7.8 Kaikōura earthquake cascade on weak crustal faults.

We present a dynamic rupture model of the 2016 M 7.8 Kaikōura earthquake to unravel the event's riddles in a physics-based manner and provide insight on the mechanical viability of competing hypotheses proposed to explain them. Our model reproduces key characteristics of the event and constraints puzzling features inferred from high-quality observations including a large gap separating surface rupture traces, the possibility of significant slip on the subduction interface, the non-rupture of the Hope fault, and slow apparent rupture speed.

Universal Electrocardiographic Screening for Long QT Syndrome in Hospitalized Neonates.

Objective: Long QT syndrome (LQTS) is a known cause of unexpected death, leading some to recommend routine neonatal electrocardiographic (ECG) screening. We used continuous electronic heart rate corrected QT interval (QTc) monitoring to screen for interval prolongation in a cohort of hospitalized neonates to identify those at a risk of having LQTS. We hypothesized that this screening method would yield an acceptable positive predictive value (PPV).

Three-dimensional modeling and numerical predictions of multimodal nonlinear behavior in damaged concrete blocks.

In this paper, the multimodal nonlinear elastic behavior of concrete, which is representative of a consolidated granular material, is modeled numerically. Starting from a local three-dimensional softening law, the initial stiffness properties are re-estimated according to the local strain field. The experiments deal with samples of thermally damaged concrete blocks successively excited around their first three modes of vibration.

Automated analysis of lipid drug-response markers by combined fast and high-resolution whole cell MALDI mass spectrometry biotyping.

Recent advances in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry have enabled whole cell-MALDI mass spectrometry biotyping of drug-treated cultured cells for rapid monitoring of known abundant pharmacodynamic protein markers such as polyacetylated histones. In contrast, generic and automated analytical workflows for discovery of such pharmacodynamic markers, in particular lipid markers, and their use in cellular tests of drug-like compounds are still lacking. Here, we introduce such a workflow and demonstrate its utility for cellular drug-response monitoring of BCR-ABL tyrosine kinase inhibitors in K562 leukemia cells: First, low-molecular mass features indicating drug responses are computationally extracted from groups of MALDI-TOF mass spectra.