Mycosis fungoides palmaris et plantaris--an unusual variant of cutaneous T-cell lymphoma.

Mycosis fungoides (MF) represents a low-risk, cutaneous, non-Hodgkin, T-cell lymphoma with a wide spectrum of clinicopathological manifestations and therefore may mimic a number of other dermatoses. Sometimes the clinical diversity makes the diagnosis of MF, and especially its atypical forms, challenging. We report on an 18-year old male patient, who had been previously diagnosed with palmoplantar eczema.

[Pseudosarcomatous variant of a genital fibroepithelial stromal polyp in a pregnancy].

Fibroepithelial stromal polyps are benign neoplasms of the lower genital tract occurring mostly in young to middle-aged women in their reproductive years. Clinically they appear as tender, skin-colored, sack-like tumors and usually have a bland microscopic appearance. Sometimes, especially during pregnancy or with hormone therapy, a worrisome hypercellular and pseudosarcomatous pattern can be seen in the dermis.

Proteinase-activated receptor-2 mediates itch: a novel pathway for pruritus in human skin.

We examined whether neuronal proteinase-activated receptor-2 (PAR-2) may be involved in pruritus of human skin. The endogenous PAR-2 agonist tryptase was increased up to fourfold in atopic dermatitis (AD) patients. PAR-2 was markedly enhanced on primary afferent nerve fibers in skin biopsies of AD patients.

Prostaglandin E2 induces vasodilation and pruritus, but no protein extravasation in atopic dermatitis and controls.

Background: Prostaglandin E(2) (PGE(2)) has well-established vasodilatory effects, whereas its effects on protein extravasation and its sensory effects are less clear.

Objective: Vasoactive effects of PGE(2) were correlated to its ability to evoke pain or itch in healthy volunteers and patients with atopic dermatitis (AD).

Methods: Intradermal microdialysis was used to apply PGE(2) (10(-8)-10(-4) M) via microdialysis capillaries in 8 patients and 8 controls.