Publications by authors named "Ulrich Goepfert"
Importance: SARS-CoV-2 viral load (VL) in the nasopharynx is difficult to quantify and standardize across settings, but it may inform transmission potential and disease severity.
Objective: To characterize VL at COVID-19 diagnosis among previously uninfected and unvaccinated individuals by evaluating the association of demographic and clinical characteristics, viral variant, and trial with VL, as well as the ability of VL to predict severe disease.
Design, Setting, And Participants: This secondary cross-protocol analysis used individual-level data from placebo recipients from 4 harmonized, phase 3 COVID-19 vaccine efficacy trials sponsored by Moderna, AstraZeneca, Janssen, and Novavax.
Article Synopsis
- Study explores the protective effects of previous SARS-CoV-2 infection and hybrid immunity (infection plus vaccination) against COVID-19, using data from various vaccine trials.
- Participants were grouped based on their previous infection status and whether they received a vaccine, with a main focus on confirmed COVID-19 cases post-treatment.
- Results indicated that individuals with previous infections had a significantly lower risk of contracting COVID-19, and hybrid immunity generally offered better protection than vaccination alone, emphasizing the effectiveness of both natural infection and vaccination in preventing severe disease.
Importance: Current data identifying COVID-19 risk factors lack standardized outcomes and insufficiently control for confounders.
Objective: To identify risk factors associated with COVID-19, severe COVID-19, and SARS-CoV-2 infection.
Design, Setting, And Participants: This secondary cross-protocol analysis included 4 multicenter, international, randomized, blinded, placebo-controlled, COVID-19 vaccine efficacy trials with harmonized protocols established by the COVID-19 Prevention Network.