Optimization Rules for SARS-CoV-2 M Antivirals: Ensemble Docking and Exploration of the Coronavirus Protease Active Site.

Coronaviruses are viral infections that have a significant ability to impact human health. Coronaviruses have produced two pandemics and one epidemic in the last two decades. The current pandemic has created a worldwide catastrophe threatening the lives of over 15 million as of July 2020.

Cerebellar haemorrhage mimicking acute peripheral vestibulopathy: the role of the video head impulse test in differential diagnosis.

Dizziness and vertigo without neurological signs are typically due to a peripheral vestibular disease. Although the most common causes are benign, differential diagnosis must include potentially life-threatening central diseases such as cerebrovascular pathologies. A systemic clinical approach needs a careful work-up, bedside examination and appropriate instrumental investigation.

Vestibular function outcomes after vestibular neurectomy in Meniere disease: can vestibular neurectomy provide complete vestibular deafferentation?

Objective: Vestibular neurectomy is considered the reference treatment of incapacitating vertigo accompanying Meniere disease, with an efficiency rate of 85-95% in most literature reports. The aim of this study is to evaluate if vestibular neurectomy can provide a complete vestibular deafferentation by investigating complete vestibular function after surgery.

Methods: Prospective study.

[Skull vibration induced nystagmus test].

Objectives: To establish during a consensus meeting the fundamental basis, the validity criteria, the main indications and results of the skull vibration induced nystagmus test (SVINT) which explores the vestibule high frequencies.

Material And Methods: The SVINT is applied on the mastoid process (right and left sides) at 100 Hz during 10 seconds on a sitting upright subject. Total unilateral peripheral lesions (tUVL: operated vestibular shwannomas, vestibular neurectomies) and partial unilateral peripheral lesions (pUVL: preoperative neuromas, Meniere's disease, vestibular neuritis, chemical labyrinthectomies) were studied.

[Curthoys and Halmagyi Head Impulse test: an analytical device].

Unlabelled: Described in 1988 by Curthoys and Halmagyi, the Head Impulse test enables checking the individual response of each of the six semicircular canals to fast head movements within less than one minute. Interpretation of test results requires careful clinical observation of the eye/head synchronism. But, due to the very short duration of the phenomenon, such synchronism is often difficult to confirm.

[Vibration-induced nystagmus: mechanism and clinical interest].

Unlabelled: In 1973 Lücke described nystagmus induced by application of a vibrator on the mastoid process. Since that time, several Authors have applied the vibrator test in normal subjects or patients suffering from various well-characterized conditions.

Objective: Recognizing that results obtained with the vibrator test are sometimes in contradiction with those of other vestibular tests, our aim was to formulate an assumption regarding the genesis of induced nystagmus in an attempt to explain such contradictions.

Synthesis and 5-HT2A radioligand receptor binding assays of DOMCl and DOMOM, two novel 5-HT2A receptor ligands.

A synthesis of two new active substances, DOMCl (1-(4-chloromethyl-2, 5-dimethoxyphenyl)-2-propanamine; 2) and DOMOM (1-(2, 5-dimethoxy-4-methoxymethylphenyl)-2-propanamine; 3), was developed. Unexpectedly, the Blanc reaction permitted successful synthesis of 2, 5-dimethoxyphenylpropylamine derivatives having a substituted methyl group in position 4 since solvation of the reactant occurs during the reaction. Afterwards, their affinities towards the 5-HT(2A) receptor were examined in 5-HT(2A) radioligand receptor binding assays.

[Bilateral vestibular areflexia: quantification is required].

Bilateral vestibular loss, that should be more precisely qualified as "horizontal semicircular canal bilateral loss", is a concept usually defined by the following characteristics: - no response to caloric tests, - no response to pendular test with a 20-second period, - increasing gain of the cervico-ocular reflex. We present five cases. We increased the stimulation frequency to a level higher than usually, employed and observed that: - at a given frequency threshold a certain amount of reactivity may be observed, - above that threshold the reactivity increases in proportion with stimulation frequency.

[Using interaction-intensive therapeutic nursing measures and "home remedies" in nursing care. An explorative study as a plea for integrated nursing practice].

Background: Until today there existed no major studies about the wide range of currently utilized methods or potential sociodemographic and institutional influences on utilization despite an immense interest among nurses in alternative nursing methods (in this study referred to as home remedies).

Methods: In this study, from standardized questionnaires with a convenience sample of three different settings of nursing practice, i.e.

[Disorders in gaze saccades in Huntington disease. Clinical correlations].

Oculomotor abnormalities have long been recognized in Huntington's disease (HD). The precise correlation between them and other clinical findings has not yet been determined. Using videonystagmography, we studied reflexive, visually guided horizontal saccades in 32 patients with genetically confirmed HD: nine female and 23 male patients, including six with young onset HD (YOHD), 19 with adult onset HD (AOD), and seven with late onset HD (LOHD).

[Speed of ocular saccades in Huntington disease. Prospective study].

Background: Oculomotor abnormalities, especially slow saccades, have long been recognized in Huntington's disease (HD).

Objectives And Methods: To study prospectively horizontal saccade velocity by videonystagmography in 21 patients with genetically confirmed HD. The study included a baseline analysis and a second evaluation after 18.

[Eating and drinking in patients with Alzheimer dementia. A study of interactions].

Eating and drinking become difficult for people afflicted with dementia. We have therefore analysed the mealtime constellation in five cases of institutionalised people suffering from Alzheimer using video in an open technique. The process of eating and drinking entailed intensive interaction between patients and their nurses.

[Rotatory impulse test does not replace caloric tests].

We sought to determine whether the rotatory impulsional test was capable of exploring the canalar function with sufficient precision to replace the caloric test, as it has been recently affirmed. We first compared the observed preponderance from this test with that measured during a sinusoidal (20 and 4 s) test. We observed that, in the case of a significant preponderance for a given test, there was complete redondance with the preponderance observed with any other test.

3-D eye movement measurements on four Comex's divers using video CCD cameras, during high pressure diving.

Previous studies have shown the vulnerability of the vestibular system regarding barotraumatism (1) and deep diving may induce immediate neurological changes (2). These extreme conditions (high pressure, limited examination time, restricted space, hydrogen-oxygen mixture, communication difficulties etc.) require adapted technology and associated fast experimental procedure.

On the role of the olivocochlear bundle in hearing: a case study.

A young patient with normal pure-tone thresholds in both ears underwent a unilateral vestibular neurotomy in January 1992 to relieve severe vertigo ascribed to Ménière's disease. Evidence is provided that the whole vestibular nerve including the olivocochlear bundle (OCB) was sectioned. Just prior to the surgery, the patient was examined in several psychoacoustic tests involving mainly signal detection and selective attention.

[Vestibular compensation. Clinical value of its dynamic study].

Vestibular compensation consists of all the processes of neurological reorganization that allow recovering balance after a unilateral vestibular lesion. According to its etiology, the peripheral lesion may be more or less severe, may evolve more or less rapidly, and be more or less reversible. Therefore, it will have a characteristic "pattern" in time, which enables us to classify the kinetic aspects of peripheral pathology.