Triiodothyronine treatment in mice improves stroke outcome and reduces blood-brain barrier damage.

Objective Thyroid hormones (TH) control a variety of processes in the central nervous system and influence its response to different stimuli, such as ischemic stroke. Post-stroke administration of 3,3',5-triiodo-L-thyronine (T3) has been reported to substantially improve outcomes, but the optimal dosage and time window remain elusive. Methods Stroke was induced in mice by transient middle cerebral artery occlusion (tMCAO) and T3 was administered at different doses and time points before and after stroke.

Prognostic value of Doppler echocardiographic coronary flow velocity assessment at rest in elderly patients.

Background: Atherosclerosis and coronary artery disease (CAD) are a common condition and cause of death in the elderly population. There are difficulties with risk assessment in the elderly as the objectification of their symptomatic status can be challenging due to neuromuscular weakness, physical deconditioning or neurological, orthopaedic, peripheral vascular, or respiratory limitations. Non-invasive coronary artery velocity assessment by Doppler method at rest could be helpful in the elderly population.

Character Strengths of Czech Army Excellent Officers as Perceived by Cadets and Soldiers Serving in Reconnaissance Units.

Introduction: A deeper understanding of personality specifics in military personnel may increase the efficacy of health care professionals in this field. Changes in modern warfare require army officers to make decisions in complicated situations with increasing levels of autonomy. Character is traditionally regarded as a key quality in these dynamics.

Additive prognostic value of high baseline coronary flow velocity to ejection fraction during resting echocardiography: 3-year prospective study.

Background: There is a lack of information about the prognostic value of high velocity in coronary arteries during echocardiography. The present study was aimed at investigating the three-year prognostic value of coronary velocity assessment in all patients who were referred for echocardiography examination.

Methods: The prospective study comprises 747 consecutive patients.

Influence of Patient-Specific Covariates on Test Validity of Two Delirium Screening Instruments in Neurocritical Care Patients (DEMON-ICU).

Background: Delirium screening instruments (DSIs) should be used to detect delirium, but they only show moderate sensitivity in patients with neurocritical illness. We explored whether, for these patients, DSI validity is impacted by patient-specific covariates.

Methods: Data were prospectively collected in a single-center quality improvement project.

Mini-review: A possible role for galanin in post-traumatic stress disorder.

Several neuroendocrine systems have been implicated in post-traumatic stress disorder, including the mesocortical and mesolimbic dopamine, the norepinephrine, the β-endorphin, the serotonin, and the oxytocin systems. The interaction between these different systems remains, however, largely unknown and a generally accepted unifying theory is thus far lacking. In this review, we suggest that galanergic suppression of dopaminergic neurons in the ventral tegmental may constitute the missing link in a post-traumatic feedback loop.

The Development of Overtrust: An Empirical Simulation and Psychological Analysis in the Context of Human-Robot Interaction.

With impressive developments in human-robot interaction it may seem that technology can do anything. Especially in the domain of social robots which suggest to be much more than programmed machines because of their anthropomorphic shape, people may overtrust the robot's actual capabilities and its reliability. This presents a serious problem, especially when personal well-being might be at stake.

Can Robots Earn Our Trust the Same Way Humans Do? A Systematic Exploration of Competence, Warmth, and Anthropomorphism as Determinants of Trust Development in HRI.

Robots increasingly act as our social counterparts in domains such as healthcare and retail. For these human-robot interactions (HRI) to be effective, a question arises on whether we trust robots the same way we trust humans. We investigated whether the determinants competence and warmth, known to influence interpersonal trust development, influence trust development in HRI, and what role anthropomorphism plays in this interrelation.

Flavonoids against the SARS-CoV-2 induced inflammatory storm.

The disease severity of COVID-19, especially in the elderly and patients with co-morbidities, is characterized by hypercytokinemia, an exaggerated immune response associated with an uncontrolled and excessive release of proinflammatory cytokine mediators (cytokine storm). Flavonoids, important secondary metabolites of plants, have long been studied as therapeutic interventions in inflammatory diseases due to their cytokine-modulatory effects. In this review, we discuss the potential role of flavonoids in the modulation of signaling pathways that are crucial for COVID-19 disease, particularly those related to inflammation and immunity.

The Eternal Robot: Anchoring Effects in Humans' Mental Models of Robots and Their Self.

Current robot designs often reflect an anthropomorphic approach, apparently aiming to convince users through an ideal system, being most similar or even on par with humans. The present paper challenges human-likeness as a design goal and questions whether simulating human appearance and performance adequately fits into how humans think about robots in a conceptual sense, i.e.

Common components of nurse manager development programmes: A literature review.

Aims: To critically appraise contemporary literature and synthesize common components of nurse manager development programmes.

Background: Although the need for nurse manager development programmes has been well documented, minimal recent research exists which identifies and evaluates the common components in these programmes. Furthermore, nurse managers continue to be poorly prepared and supported in role transition, contributing to poor organisational and role performance and decreased retention.

A novel theory on the predictive value of variation in the β-endorphin system on the risk and severity of PTSD.

Despite growing interest in genetic and psychosocial indicators of heightened susceptibility to posttraumatic stress disorder (PTSD), a predictive model, which explains why some individuals develop PTSD in response to life-threatening traumatic events, while others, when faced with the same or similar experiences, do not, has thus far remained out of reach. In this paper, we review the literature on gene-environment interactions in β-endorphin system functioning with regard to PTSD and suggest that variation, both genetic and with regard to environmental stimuli, in systems which, like the β-endorphin system, distort human perception of life-threatening traumatic experiences may account for some of the variance in resilience to the disorder. Given the role of β-endorphin in both social connections and physical exercise, this becomes especially relevant with regard to military selection, training, and leadership processes.

Case report-delayed splenic rupture in combination with medial femoral neck fracture after low energy trauma. Development of hemorrhagic shock 5 days after hip prosthesis due to a rare cause.

A 79 year old female patient was admitted to our emergency department with a fracture of the right medial femoral neck six days after a fall on her right side and a cemented hemiprosthesis was implanted. Five days later, she developed a hemorrhagic shock and was diagnosed with a delayed splenic rupture and the spleen was resected. Histopathological examination showed a delayed rupture of an otherwise normal spleen without signs of an underlying pathology.

Vaccination during concurrent subcutaneous immunotherapy: safety of simultaneous application.

Background: During subcutaneous immunotherapy (SCIT), injections should be separated from vaccinations against infectious diseases by at least 1 week, because it is assumed that adverse reactions can result from the additional activation of the immune system.

Metarial And Methods: Data of a total of 875 individuals receiving SCIT and/or vaccination in one ENT-practice were included and analyzed retrospectively. 444 individuals had received vaccination against infectious diseases, 336 allergic patients received only SCIT.

A longitudinal assessment of early childhood education with integrated speech therapy for children with significant language impairment in Germany.

Background: In Lower Saxony, Germany, pre-school children with language- and speech-deficits have the opportunity to access kindergartens with integrated language-/speech therapy prior to attending primary school, both regular or with integrated speech therapy. It is unknown whether these early childhood education treatments are helpful and effective.

Aims: To determine the value of early language-/speech therapy treatment in combination with support of personality traits during the pre-school and primary school period on the long-term social and academic development of children with significant language-/speech delay.

German environmental survey IV: children's exposure to environmental tobacco smoke.

Different aspects of the environmental tobacco smoke (ETS) exposure of children in Germany have been investigated in the German Environmental Survey for Children (GerES IV). The field work of GerES IV was conducted from 2003 to 2006 using questionnaires, indoor air monitoring and human biomonitoring. About half of Germany's 3- to 14-year-old children lived in households with at least one smoker.

[Long-term school-development of children with impaired language skills: 15-years follow up after dismissal from child care centres with speech therapy].

Background: Severe language impairment (SLI) in children causes multiple developmental disturbances. Less is known concerning the long-term efficacy of Child care centres with speech therapy (CCC) and the validity of of IQ-testing.

Aim Of The Study: Follow-up of school-development of SLI-children from CCC and analysis of the the prognostic relevance of IQ-testing as monitored by the surrogate-parameter "school-development".

Allylation and vinylation of aryl radicals generated from diazonium salts.

Allylation and vinylation of aryl radicals generated from aryl diazonium salts provides rapid and efficient access to chlorinated and brominated derivatives of styrene and allylbenzene. Allyl chlorides were found to be better substrates than bromides due to decreased halogen transfer. Donor- and acceptor-substituted diazonium salts are well tolerated.

[Comparison of gold-plated silver- and silver oxide-impregnated silastic tympanostomy tubes: a randomized, prospective clinical trial].

Unlabelled: The insertion of tympanostomy tubes is the most common surgical procedure in the world. A major complication of chronic intubation is infectious otorrhea. The present study compares the rate of infectious otorrhea and survival rate of gold-plated silver tubes (GPR) vs.

DEHP metabolites in urine of children and DEHP in house dust.

Urine samples from the 2001/2002 pilot study for the German Environmental Survey on children (GerES IV) were analysed for concentrations of the primary DEHP metabolite MEHP (mono(2-ethylhexyl)phthalate) and two secondary DEHP metabolites SOH-MEHP (2-ethyl-5-hydroxy-hexylphthalate) and 5oxo-MEHP (2-ethyl-5-oxo-hexylphthalate). Urine samples had been taken from 254 children aged 3 to 14. In addition, DEHP was analysed in house dust samples.

[Environmental Survey for Children-- the environmental module of KiGGS. I. Design and research program].

The German Environmental Survey for Children (GerES IV) is the environment-oriented module of the National Health Interview and Examination Survey for Children and Adolescents (KiGGS) which is being performed nationwide in Germany. From 2003 to 2006, a random subsample of 1800 children aged 3-14 years is being studied with regard to their body burden and health impairments linked to housing conditions and the personal environment- and health-relevant behaviour. The basic study programme includes the analysis of blood, urine, tap water and house dust as well as the application of an extensive questionnaire.

[Might the cooperation with neuropediatricians improve the treatment of hearing impaired children: retrospective analysis of a small group of children with hearing aids].

Question: Present analysis was performed to test the hypothesis, that cooperation with neuropediatricians might improve the treatment of hearing impaired children.

Study-design: In a retrospective study 31 children (21 females, 10 males) with impaired sensorineural hearing (27 binaural, 4 monaural) and hearing aids were analyzed: - 12 children with profound and severe hearing loss (HL), median diagnostic age (mda): 8 months; - 15 children with moderate and mild HL, mda: 58 months and - 4 children with monaural HL, mda: 29 months. Neuropediatric examination included physical examination as well as psychometric testing.

Texas entry-year agriculture teachers' perceptions, practices, and preparation regarding safety and health in agricultural education.

The purpose of this study was to gather benchmark data for the assessment of the knowledge, attitudes, and perceptions regarding agricultural safety issues and curricula held by Texas agricultural teachers with less than two full years of teaching experience (entry-year teachers). Seventy-four of 118 well-distributed teachers responded to this survey. Researchers concluded that more females were entering a traditionally male-dominated field.

[Physical and biomechanical aspects of cervical vertebrae dislocation syndrome].

Results: In car-accidents forces and torquets influence the cervical vertebra by traction and torsion. Moreover, due to different acceleration of head and body the cervical spine has to absorb and transmit--very often--great additional impulses. These different physical effects might cause damages of the cervical spine, whereby the acceleration (i.

The German Environmental Survey 1990/92 (GerES II): sources of personal exposure to volatile organic compounds.

In the framework of the second German Environmental Survey carried out in the Western part of Germany in 1990/91 (GerES IIa) 113 adults aged 25-69 years were selected at random from the total study population of about 2500 to investigate personal exposure to about 70 volatile organic compounds (VOCs). Each subject wore a diffusive badge-type sampler for 1 week. The VOCs determined included alkanes, aromatics, aliphatic halocarbons, terpenes, and oxygen-containing compounds.