The detection of automatic behavior in other people.

The standard model of theory of mind posits that we attribute mental states to other people to explain their behavior. However, what of cases in which we think the other person is being scripted, acting automatically with no goals or beliefs to recover? While a great deal of past work has distinguished between automatic and reflective behaviors in one's own decision making, here we argue that reasoning about automatic behavior in other people is an important and largely unexplored area in research into theory of mind. We report results from two studies (N = 4,528 total) that examine the detection of automatic behavior in others.

Electrophysiology Reveals That Intuitive Physics Guides Visual Tracking and Working Memory.

Starting in early infancy, our perception and predictions are rooted in strong expectations about the behavior of everyday objects. These intuitive physics expectations have been demonstrated in numerous behavioral experiments, showing that even pre-verbal infants are surprised when something impossible happens (e.g.

Approximate planning in spatial search.

How people plan is an active area of research in cognitive science, neuroscience, and artificial intelligence. However, tasks traditionally used to study planning in the laboratory tend to be constrained to artificial environments, such as Chess and bandit problems. To date there is still no agreed-on model of how people plan in realistic contexts, such as navigation and search, where values intuitively derive from interactions between perception and cognition.

Blending simulation and abstraction for physical reasoning.

How are people able to understand everyday physical events with such ease? One hypothesis suggests people use an approximate probabilistic simulation of the world. A contrasting hypothesis is that people use a collection of abstractions or features. While it has been noted that the two hypotheses explain complementary aspects of physical reasoning, there has yet to be a model of how these two modes of reasoning can be used together.

Making Multiplexed Imaging Flexible: Combining Essential Markers With Established Antibody Panels.

Multiplexed immunofluorescence (IF) can be achieved using different commercially available platforms, often making use of conjugated antibodies detected in iterative cycles. A growing portfolio of pre-conjugated antibodies is offered by the providers, as well as the possibility for conjugation. For many conjugation methods and kits, there are limitations in which antibodies can be used, and conjugation results are sometimes irreproducible.

Ambivalence by design: A computational account of loopholes.

Loopholes offer an opening. Rather than comply or directly refuse, people can subvert an intended request by an intentional misunderstanding. Such behaviors exploit ambiguity and under-specification in language.

When Perfect Is the Enemy of Good: Results of a RAND Appropriateness Panel on Treat to Target in Asymptomatic Inflammatory Bowel Disease.

Background: A treat-to-target strategy for inflammatory bowel disease (IBD) recommends iterative treatment adjustments to achieve clinical and endoscopic remission. In asymptomatic patients with ongoing endoscopic activity, the risk/benefit balance of this approach is unclear, particularly with prior exposure to advanced therapies.

Methods: Using the RAND/University of California Los Angeles Appropriateness Method, 9 IBD specialists rated appropriateness of changing therapy in 126 scenarios of asymptomatic patients with ulcerative colitis and Crohn's disease and active endoscopic disease.

Genies, lawyers, and smart-asses: Extending proxy failures to intentional misunderstandings.

We propose that the logic of a genie - an agent that exploits an ambiguous request to intentionally misunderstand a stated goal - underlies a common and consequential phenomenon, well within what is currently called proxy failures. We argue that such intentional misunderstandings are not covered by the current proposed framework for proxy failures, and suggest to expand it.

What is "Where": Physical Reasoning Informs Object Location.

A central puzzle the visual system tries to solve is: "what is where?" While a great deal of research attempts to model object recognition ("what"), a comparatively smaller body of work seeks to model object location ("where"), especially in perceiving everyday objects. How do people locate an object, right now, in front of them? In three experiments collecting over 35,000 judgements on stimuli spanning different levels of realism (line drawings, real images, and crude forms), participants clicked "where" an object is, as if pointing to it. We modeled their responses with eight different methods, including both human response-based models (judgements of physical reasoning, spatial memory, free-response "click anywhere" judgements, and judgements of where people would grab the object), and image-based models (uniform distributions over the image, convex hull, saliency map, and medial axis).

An approximate representation of objects underlies physical reasoning.

People make fast and reasonable predictions about the physical behavior of everyday objects. To do so, people may use principled mental shortcuts, such as object simplification, similar to models developed by engineers for real-time physical simulations. We hypothesize that people use simplified object approximations for tracking and action (the representation), as opposed to fine-grained forms for visual recognition (the representation).

Non-commitment in mental imagery.

We examine non-commitment in the imagination. Across 5 studies (N > 1, 800), we find that most people are non-committal about basic aspects of their mental images, including features that would be readily apparent in real images. While previous work on the imagination has discussed the possibility of non-commitment, this paper is the first, to our knowledge, to examine this systematically and empirically.

Rethink reporting of evaluation results in AI.

Aggregate metrics and lack of access to results limit understanding.

Improvements in Disease Activity Partially Mediate the Effect of Tofacitinib Treatment on Generic and Disease-Specific Health-Related Quality of Life in Patients with Ulcerative Colitis: Data from the OCTAVE Program.

Background: Patients with ulcerative colitis (UC) often report impaired health-related quality of life (HRQoL). Tofacitinib is an oral small molecule Janus kinase inhibitor for the treatment of UC. In addition to previous demonstrations of improved clinical measures (e.

Dangerous Ground: One-Year-Old Infants are Sensitive to Peril in Other Agents' Action Plans.

Do infants appreciate that other people's actions may fail, and that these failures endow risky actions with varying degrees of negative utility (i.e., danger)? Three experiments, including a pre-registered replication, addressed this question by presenting 12- to 15-month-old infants ( = 104, 52 female, majority White) with an animated agent who jumped over trenches of varying depth towards its goals.

COVID-19 is not associated with worse long-term inflammatory bowel disease outcomes: a multicenter case-control study.

Background: Inflammatory bowel disease (IBD) is not associated with worse coronavirus disease 2019 (COVID-19) outcomes. However, data are lacking regarding the long-term impact of severe acute respiratory syndrome coronavirus 2 infection on the disease course of IBD.

Objectives: We aimed to investigate the effect of COVID-19 on long-term outcomes of IBD.

The Real-World Effectiveness and Safety of Ustekinumab in the Treatment of Crohn's Disease: Results From the SUCCESS Consortium.

Introduction: We evaluated the real-world effectiveness and safety of ustekinumab (UST) in patients with Crohn's disease (CD).

Methods: This study used a retrospective, multicenter, multinational consortium of UST-treated CD patients. Data included patient demographics, disease phenotype, disease activity, treatment history, and concomitant medications.

Racial Difference in Efficacy of Golimumab in Ulcerative Colitis.

Background: Observational studies have described racial differences in inflammatory bowel disease (IBD) genetics, clinical manifestations, and outcomes. Whether race impacts response to biologics in IBD is unclear. We conducted a post hoc analysis of phase 2 and 3 randomized clinical trials in ulcerative colitis to evaluate the effect of race on response to golimumab.

Partial mental simulation explains fallacies in physical reasoning.

People can reason intuitively, efficiently, and accurately about everyday physical events. Recent accounts suggest that people use mental simulation to make such intuitive physical judgments. But mental simulation models are computationally expensive; how is physical reasoning relatively accurate, while maintaining computational tractability? We suggest that people make use of , mentally moving forward in time only parts of the world deemed relevant.

National Prevalence of Psychological Distress and Use of Mental Health Care in Inflammatory Bowel Disease.

Background: Individuals with inflammatory bowel disease (IBD) have elevated symptoms of anxiety and depression. The burden of such symptoms, accompanied by functional impairment in IBD, is not well documented, nor is utilization of mental health care in this population.

Methods: Adults ≥18 years were identified in the cross-sectional 2015-2016 National Health Interview Survey.

Appropriateness of Medical and Surgical Treatments for Chronic Pouchitis Using RAND/UCLA Appropriateness Methodology.

Background And Aims: The treatment of chronic pouchitis remains a challenge due to the paucity of high-quality studies. We aimed to provide guidance for clinicians on the appropriateness of medical and surgical treatments in chronic pouchitis.

Methods: Appropriateness of medical and surgical treatments in patients with chronic pouchitis was considered in 16 scenarios incorporating presence/absence of four variables: pouchitis symptoms, response to antibiotics, significant prepouch ileitis, and Crohn's disease (CD)-like complications (i.