[Effect of tamoxifen in lipids of diabetic rats induced by streptozotocin].

Objective: To evaluate the effect of tamoxifen in the lipidic and renal profile in diabetic and control rats.

Methods: 40 female Wistar rats had been used (180-220g corporal weight), divided randomly in 4 groups: C (n = 10, received vehicle), T (n = 10, treated with tamoxifen, 0.3mg/kg/day), D (n = 10, diabetic induced by streptozotocin, 45mg/Kg) and DT (n = 10, diabetic treated with tamoxifen).

Osteopenia: a bone disorder associated with diabetes mellitus.

Although osteopenia has been associated with human diabetes mellitus, the pathogenesis of diabetic osteopenia is unclear. In the present study, we evaluated the effect of diabetes on histomorphometry, bone mineral density (BMD)-measured by dual-energy X-ray absorptiometry (DXA)-and biomarkers of bone metabolism in rats up to 120 days after the onset of experimental diabetes. Female Wistar rats with a regular estrous cycle were randomly divided into two groups: control rats (n = 15) and diabetic rats without insulin treatment (n = 25).