Publications by authors named "Ulises D'Andrea Nores"
Open Forum Infect Dis
December 2023
Article Synopsis
- Incidence rates of respiratory syncytial virus-associated lower respiratory tract illness (RSV-LRTI) in infants were assessed in low- and middle-income countries (LMICs) as existing data was limited.
- The study followed 2,094 infants from 10 LMICs over one year, using surveillance and testing to identify cases during the COVID-19 pandemic.
- Results indicated a low incidence of RSV-LRTI (1.5% of infants) and all-cause lower respiratory tract infections, likely influenced by reduced viral activity during the pandemic.
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Article Synopsis
- A phase 2 and 3 clinical trial was conducted to evaluate the safety and effectiveness of two monoclonal antibodies, amubarvimab and romlusevimab, in treating patients with SARS-CoV-2 who are at high risk for severe illness.
- *The trial involved 807 participants across multiple countries, showing that the antibody combination significantly reduced hospitalizations and deaths by 79% compared to a placebo group, with fewer severe adverse events reported.
- *However, a limitation of the study is that the majority of participants were unvaccinated against COVID-19, which may impact the generalizability of the results.
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