Organocatalytic Electrophilic Arene Amination: Rapid Synthesis of 2-Quinolones.

For decades, the synthesis of 2-quinolones, a crucial structural motif in pharmaceuticals and agrochemicals, has relied heavily on costly noble metal complexes and structurally complex ligands. Despite considerable efforts from synthetic chemists, a mild, metal-free, environmentally friendly, and cost-effective approach has remained elusive. This study introduces a robust, metal-free synthetic platform that leverages an innovative organoiodine-catalyzed electrophilic arene C(sp)-H amination strategy to efficiently produce a wide range of new and modifiable 2-quinolones.

Forging structural complexity: diastereoselective synthesis of densely substituted β-lactams with dual functional handles for enhanced core modifications.

The preparation of the β-lactam motif containing both C-Br and N-O bonds as functional handles remains an unmet synthetic challenge. Described herein is a novel and highly diastereoselective NBS-mediated cyclization of alkoxy α,β-unsaturated silyl imino ethers to furnish nearly three dozen α-bromo -alkoxy β-lactams. The reaction gives rapid and convenient access to structurally diverse monocyclic, spirocyclic and fused β-lactams in moderate to good yields.

Benzyl-hexa-decyl-dimethyl-ammonium chloride dihydrate.

The title compound, CHN·Cl·2HO, crystallizes in the space group 2 with one organic mol-ecule in the asymmetric unit. The compound belongs to a class of benzalkonium chlorides (BACs) with an alkyl chain length of 16 carbon atoms in an all- conformation.