Publications by authors named "Ulf Dehio"
Stem Cell Res Ther
March 2021
Article Synopsis
- The study focuses on treating severe limbal stem cell deficiency (LSCD) by using a new marker, ABCB5, which helps identify and enrich limbal stem cells (LSCs) for transplantation, improving therapeutic outcomes.
- Researchers developed a standardized production process to create advanced-therapy medicinal products (ATMPs) from ABCB5 LSCs derived from human cadaveric limbal tissue, ensuring high-quality cell expansion and isolation.
- Preclinical trials showed that these ABCB5 LSCs could safely engraft without causing toxicity or tumors, leading to approval by regulatory agencies for a clinical trial to further assess their safety and effectiveness in treating LSCD.
Article Synopsis
- - The study focuses on ABCB5-expressing mesenchymal stromal cells (MSCs) from human skin as a potential therapy for currently untreatable diseases, having developed a method to isolate and process these cells in line with international safety standards.
- - Extensive safety testing was conducted on ABCB5 MSCs, revealing no harmful effects such as abnormal cell growth, tumor formation, or adverse tissue reactions in animal models.
- - Results indicate that ABCB5 MSCs are safe and tolerable for local and systemic use, supporting their development as a new advanced-therapy medicinal product.
