Vaccination coverage in children with juvenile idiopathic arthritis, inflammatory bowel diseases, and healthy peers: Cross-sectional electronic survey data.

Background: Patients with immune-mediated diseases, such as juvenile idiopathic arthritis (JIA) and inflammatory bowel disease (IBD) are at increased risk of developing infections, due to disease-related immune dysfunction and applying of immunosuppressive drugs.

Aim: To evaluate vaccine coverage in patients with IBD and JIA, and compare it with healthy children.

Methods: In the cross-sectional study we included the data from a questionnaire survey of 190 Legal representatives of children with JIA ( = 81), IBD ( = 51), and healthy children (HC, = 58).

[The impact of BMI on the course of the acute SARS-COV-2 infection and the risks that emerge during the first year after the hospital discharge. Subanalysis evidence of the AKTIV and AKTIV 2 registries].

Background: There is enough evidence of the negative impact of excess weight on the formation and progression of res piratory pathology. Given the continuing SARS-CoV-2 pandemic, it is relevant to determine the relationship between body mass index (BMI) and the clinical features of the novel coronavirus infection (NCI).

Aim: To study the effect of BMI on the course of the acute SARS-COV-2 infection and the post-covid period.

[ACTIV SARS-CoV-2 registry (Analysis of Chronic Non-infectious Diseases Dynamics After COVID-19 Infection in Adult Patients). Assessment of impact of combined original comorbid diseases in patients with COVID-19 on the prognosis].

Aim: Study the impact of various combinations of comorbid original diseases in patients infected with COVID-19 later on the disease progression and outcomes of the new coronavirus infection.

Materials And Methods: The ACTIV registry was created on the Eurasian Association of Therapists initiative. 5,808 patients have been included in the registry: men and women with COVID-19 treated at hospital or at home.

Analysis of influence of background therapy for comorbidities in the period before infection on the risk of the lethal COVID outcome. Data from the international ACTIV SARS-CoV-2 registry («Analysis of chronic non-infectious diseases dynamics after COVID-19 infection in adult patients SARS-CoV-2»).

Aim      To study the effect of regular drug therapy for cardiovascular and other diseases preceding the COVID-19 infection on severity and outcome of COVID-19 based on data of the ACTIVE (Analysis of dynamics of Comorbidities in paTIents who surVived SARS-CoV-2 infEction) registry.Material and methods  The ACTIVE registry was created at the initiative of the Eurasian Association of Therapists. The registry includes 5 808 male and female patients diagnosed with COVID-19 treated in a hospital or at home with a due protection of patients' privacy (data of nasal and throat smears; antibody titer; typical CT imaging features).

[From uncertainty to an exact number: Developing a method to estimate the fitness of a clonal species with poly variant ontogeny].

The task to estimate the fitness of a clonal plant with polyvariant ontogeny reduces to compiling a life cycle graph, constructing and calibrating the corresponding matrix model of the discrete-structured population, and calculating the dominant eigenvalue (λ1) of the model matrix. We demonstrate a solution to this task with a sample of Calamagrostis epigeios , a perennial long-rhizome grass propagating vegetatively, and data on the age-stage structure of its local population. A traditional technique of successive censuses fixing the age-stage status of all individuals on a permanent sample plot (SP) provides for calculating frequencies of ontogenetic transitions directly from the data, but leaves uncertain the status-specific reproduction rates as the recruit parents are unknown (“reproductive uncertainty”).

[Polyvariant ontogeny in woodreeds: Novel models and new discoveries].

Polyvariant ontogeny (PVO) is expressed visually in the life cycle graphs (LCGs) for Calamagrostis woodreeds as a variety of pathways for individual plants to develop through many of their states distinguishable by the ontogenetic stage and chronological age (in years). PVO is recognized as the basic mechanism of adaptation in local plant populations to their environments, while they find a quantitative measure of the adaptation via developing a matrix model of double-structured population, calibrating the matrix of vital rates from empirical data, and calculating its dominant eigenvalue λ1. This approach encounters an obstacle typical for rhizome grasses: while the rates of aging and ontogenetic transitions can be deterinined from field data mainly by the morphology of aboveground parts of the plant, the rates of vegetative propagation can be reliably determined only from digging up the belowground rhizome system, i.

[DIFFERENCES IN ADAPTIVE BEHAVIORS IN ADOLESCENT MALE AND FEMALE RATS EXPOSED AS NEWBORNS TO INFLAMMATORY PAIN OR STRESS].

In adolescent rats (25-35-day-old) exposed as newborns (the first and repeatedly second days) to adverse impacts (inflammatory pain, stress of short-term maternal separation or their combination) sex dimorphism was revealed in pain behavior under conditions of similar peripheral inflammation. According to the priority data obtained, strengthening of pain-related response in the formalin test was found in males, whereas pain sensitivity in females was not changed, that is pain experienced by them as newborns did not affect the system reactivity to the same chemical irritant in the adolescent period. However, the rats of both sexes, who experienced short-term stress of maternal deprivation (60 min-during the first and the second days of life), displayed increased pain sensitivity in the formalin test.

[Long-term changes in adaptive behavior of rats after neonatal inflammatory pain].

In this study we addressed the tonic nociceptive system functional activity in the formalin test, anxiety- and depression-like behaviors and spatial learning in adolescent male rats exposed in the neonatal development to repeated inflammatory pain peripheral stimulation. The following groups of 25-day-old rats were used after being exposed on days 7 and 8 to: 1) formalin-induced inflammatory pain with maternal separation for 60 min (FS), 2) the same inflammatory pain stimulation without maternal separation (FWS), 3) physiological saline injection with maternal separation for 1 h (SS), 4) physiological saline injection without maternal separation (SWS) and 5) no stimulation (intact rats). The data obtained indicate that pain caused in 7-8-day-old rat pups by formalin injection into the plantar pad of the hind paw manifests by adolescence (day 25 as a strengthened inflammatory response under the analogous painful stimulation in the formalin test, adaptive behavior disorder in the forced swimming test and spatial learning disability.

[Repeated inflammatory pain syndrome in newborn male rats changes adaptive behavior during adolescent period of development].

The study is devoted to the investigation of the effects of the repeated inflammatory pain syndrome of newborn male rat pups at the age of one and two days of life on characteristics of adaptive behaviors in the formalin test, the elevated-plus maze, the forced swim test and also in the swimming pool spatial test in these animals at the age of 25 days. The new data are enhancement of functional activity of the tonic nociceptive system, an increase in depression like behavior, impairment of spatial learning. A priority fact has been obtained that indicates that a short (60 min) repeated maternal deprivation of newborn rat pups (a stressful impact) without inflammatory noxious impact results in changes of the adaptive behaviors in 25-day-old animals.

[Two paradigms of mathematical population biology. Attempting to synthesise].

Whatever popular the slogan of nonlinear ecological interactions has been in theory, practical ecology professes the projection matrix paradigm, which is essentially linear, i.e., the linear matrix model paradigm for discrete-structured population dynamics.

[On the competition among discrete-structured populations: a matrix model for population dynamics of woodreed and birch growing together].

Presented is a synthesis of field, theoretical and modelling studies on joint dynamics of two species--common birch (Betula pendula Roth) and wood small reed (Calamagrostis epigeios (L.) Roth)--overgrowing a spruce forest clear-cut. A nonlinear matrix model for population dynamics of two species, which both possess non-trivial population structures and compete for a resource in common was developed as an expansion of the linear models for single-species, age-stage-structured population dynamics.

[The synthesis and antiherpetic activity of acyclovir phosphonate esters].

Alkyl esters of acyclovir phosphite, alkoxycarbonylphosphonate, ethoxycarbonylmethylphosphonate, and aminocarbonylphosphonate were synthesized. Most of them were shown to inhibit the replication of type 1 herpes simplex virus in Vero cell culture. The stability in phosphate buffer and human blood serum was studied for several of the derivatives.

[The structure and dynamics of woodreed Calamagrostis canescens population: a modelling approach].

A scale of ontogenetic states has been developed for woodreed Calamagrostis canescens, a perennial species dominating the grass layer of fell forest areas. The population structure is considered as a set of age-stage groups of individuals differing both in the ontogenetic stage and the chronological age measured in years. to describe the dynamics through years a special kind of matrix formalism has been proposed which is reducible neither to the classic Leslie matrix for an age-structured population, nor to the well-known Lefkovitch matrix for a stage-structured one, and which does not suffer from excessiveness of the "two-dimensional" representation for the structure implying the projection matrix of a block pattern.