[Effect of nitric oxide on viscosity of nerve cell membranes].

The influence of nitric oxide on the microviscosity of nerve cell membranes was investigated by resonance Raman (RR) spectroscopy. Changes in membrane viscosity were estimated from the resonance Raman-spectra of carotenoids localized in the axon plasmatic membrane and membranes of subcellular vesicles (cytosomes). For the nerve fibre, the extracellular addition of nitric oxide donor, sodium nitroprusside (0.

[Sensitivity of human melanoma xenografts to nitrosoalkylurea antineoplastic agents].

We studied the sensitivity of human melanoma (Bro strain) xenografts to drugs of the nitrosoalkylurea (NAU) class: nitrosomethylurea (NMM), karmustin (BCNU), nimustin (ACNU), nitrulin, and ADEKO. High antitumor activity of NAM was shown when the drugs were applied not only at the early, but also at the late stages of tumor progression (tumor mass 400 and 1200 mg, respectively). The therapeutic effect of the drugs was estimated with the use of criteria characterizing the kinetics of tumor regression, increased life span, and survival of treated animals.

[Kinetics of development of human melanoma xenografts in immunosuppressed animals].

An experimental model of development of the human tumor xenografts (melanomas HCMB and Bro) in immunosuppressed phenotypically normal animals (CBA/Ca mice) was developed. Optimal conditions were established for immunodeficiency induction in the animals. Kinetics of development of the xenografts in the immunosuppressed animals was studied.

[Immune status of adult population of the Bryansk region living in territory polluted by radionuclides].

Clinical and immunological investigation with immune status evaluation of three groups of adult population of Bryansk Region was performed. The first group included 165 persons living in Vyshkov (settlement of town type in Bryansk Region) contaminated with radionuclides as a result of Chernobyl accident. The second group included 68 persons living in Vyshkov, immunological monitoring of those was performed.

[Seasonal distribution and age structure of those ill with salmonellosis due to causative agents with different drug resistances].

The medicinal resistance of Salmonella strains isolated on the territory of the Moldavian SSR in 1985 was studied. The greatest number of multiresistant microorganisms was shown to occur among S. java, S.

[Dynamics of the etiological structure of salmonellosis and of the biological properties of the Salmonellae isolated in a selected territory of the Moldavian SSR 1982-1985].

The etiological structure of Salmonella infections and the biological properties of salmonellae, isolated in one of the regions of the Moldavian SSR where the epidemic process of Salmonella infections reflected the regularities observed on the whole territory of this republic, were studied. Changes in the predominant serovars at the period of 1982-1985 in comparison with the preceding years were shown. Salmonellae belonging to the dominating serovars were characterized by more pronounced drug resistance in comparison with other salmonellae.

[Results of prolonged study of flood plain-swamp endemic foci of tularemia, and its prophylaxis in the Leningrad Region].

The results of a prolonged (more than 18 years), comprehensive study have revealed that stable natural foci of tularemia in backwater swamps are widely spread in the Leningrad region. These foci are located in the narrow swampy flood-plains of small watercourses with adjacent meadow areas among forests. Water from such small watercourses can often serve as the indicator of the epizootic process: during the above-mentioned period 346 Francicella tularensis strain have been isolated from water and 86 strains from small mammals.