Peptidoglycan-Like Components in Z-100, Extracted from Strain Aoyama B, Increase IL-12p40 via NOD2.

Background: Z-100 is a hot-water extract of the human-type strain Aoyama B. While Z-100's macrophage-mediated immunomodulatory effects have been reported, the mechanistic details have not been fully clarified. Here, we studied the immunomodulatory effects of Z-100 on mouse bone marrow-derived cells, human CD14 cells, and skin.