Publications by authors named "Uiechan Jeong"
3D Artificial Skin Platform for Investigating Pregnancy-Related Skin Pigmentation.
Micromachines (Basel)
April 2024
In this study, we created a 3D Artificial Skin Platform that can be used for the treatment of pigmentation by artificially realizing the skin of pregnant women. For the stable realization of 3D artificial skin, a bilayer hydrogel composed of collagen type I and fibrin was designed and applied to the study to reduce the tension-induced contraction of collagen type I, the extracellular matrix (ECM) of artificial skin, by dynamic culture. Oxygen concentration and 17β-Estradiol (E2) concentration, which are highly related to melanin production, were selected as parameters of the pregnancy environment and applied to cell culture.
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- Drug screening is a critical phase in developing therapeutic interventions, focusing on evaluating substances with medicinal properties efficiently and rapidly.
- Microfluidic systems, like organ-on-a-chip and tumor-on-a-chip technologies, are revolutionizing drug screening by mimicking human organ functions and enabling fast, low-sample testing with a high degree of genetic similarity to humans.
- This review highlights the principles, benefits, and challenges of these advanced platforms, discussing their latest innovations and potential for transforming drug discovery and development in the future.*