Unlocking stray light mysteries in the CoRot baffle with the time-of-flight method.

Stray light (SL) has emerged as a primary limiting factor for space telescopes. Pre-launch testing is essential for validating performance and identifying potential issues. However, traditional methods do not enable the decomposition and identification of individual SL contributors.

Skin temperature influence on transcutaneous carbon dioxide (CO) conductivity and skin blood flow in healthy human subjects at the arm and wrist.

present transcutaneous carbon dioxide (CO)-tcpCO-monitors suffer from limitations which hamper their widespread use, and call for a new tcpCO measurement technique. However, the progress in this area is hindered by the lack of knowledge in transcutaneous CO diffusion. To address this knowledge gap, this study focuses on investigating the influence of skin temperature on two key skin properties: CO permeability and skin blood flow.

Calibration Methods for Time-to-Digital Converters.

In this paper, two of the most common calibration methods of synchronous TDCs, which are the bin-by-bin calibration and the average-bin-width calibration, are first presented and compared. Then, an innovative new robust calibration method for asynchronous TDCs is proposed and evaluated. Simulation results showed that: (i) For a synchronous TDC, the bin-by-bin calibration, applied to a histogram, does not improve the TDC's differential non-linearity (DNL); nevertheless, it improves its Integral Non-Linearity (INL), whereas the average-bin-width calibration significantly improves both the DNL and the INL.

Carbon Dioxide Sensing-Biomedical Applications to Human Subjects.

Carbon dioxide (CO2) monitoring in human subjects is of crucial importance in medical practice. Transcutaneous monitors based on the Stow-Severinghaus electrode make a good alternative to the painful and risky arterial "blood gases" sampling. Yet, such monitors are not only expensive, but also bulky and continuously drifting, requiring frequent recalibrations by trained medical staff.

Design and Characterization of an Asynchronous Fixed Priority Tree Arbiter for SPAD Array Readout.

The usage of single-photon avalanche diode arrays is becoming increasingly common in various domains such as medical imaging, automotive vision systems, and optical communications. Nowadays, thanks to the development of microelectronics technologies, the SPAD arrays designed for these applications has been drastically well-facilitated, allowing for the manufacturing of large matrices. However, there are growing challenges for the design of readout circuits with the needs of reducing their energy consumption (linked to the usage cost) and data rate.

An Ultrafast Active Quenching Active Reset Circuit with 50% SPAD Afterpulsing Reduction in a 28 nm FD-SOI CMOS Technology Using Body Biasing Technique.

An ultrafast Active Quenching-Active Reset (AQAR) circuit is presented for the afterpulsing reduction in a Single Photon Avalanche Diode (SPAD). The proposed circuit is designed in a 28 nm Fully Depleted Silicon On Insulator (FD-SOI) CMOS technology. By exploiting the body biasing technique, the avalanche is detected very quickly and, consequently, is quenched very fast.

Stray light characterization with ultrafast time-of-flight imaging.

Understanding stray light (SL) is a crucial aspect in the development of high-end optical instruments, for instance space telescopes. As it drives image quality, SL must be controlled by design and characterized experimentally. However, conventional SL characterization methods are limited as they do not provide information on its origins.

Comparison of Time Resolved Optical Turbidity Measurements for Water Monitoring to Standard Real-Time Techniques.

Environmental water monitoring requires the estimation of the suspended solids load. In this paper, we compare the concentration range accessible through three different techniques: optical turbidity, acoustic backscattering and the newly in-lab developed time resolved optical turbidity. We focus on their comparison on measurements made in the laboratory on water suspensions of known particles and concentrations.

Measuring hemoglobin spectra: searching for carbamino-hemoglobin.

Significance: The arterial carbon dioxide (CO2) partial pressure PaCO2 is a clinically relevant variable. However, its measurement requires arterial blood sampling or bulky and expensive transcutaneous PtcCO2 meters. While the spectrophotometric determination of hemoglobin species-such as oxy-hemoglobin (O2Hb) and deoxy-hemoglobin (HHb)-allowed for the development of pulse oximetry, the measurement of CO2 blood content with minimal discomfort has not been addressed yet.

Real-time optical properties and oxygenation imaging using custom parallel processing in the spatial frequency domain.

The development of real-time, wide-field and quantitative diffuse optical imaging methods is becoming increasingly popular for biological and medical applications. Recent developments introduced a novel approach for real-time multispectral acquisition in the spatial frequency domain using spatio-temporal modulation of light. Using this method, optical properties maps (absorption and reduced scattering) could be obtained for two wavelengths (665 nm and 860 nm).

Single snapshot imaging of optical properties using a single-pixel camera: a simulation study.

We present the effects of using a single-pixel camera approach to extract optical properties with the single-snapshot spatial frequency-domain imaging method. We acquired images of a human hand for spatial frequencies ranging from 0.1 to 0.

Single snapshot of optical properties image quality improvement using anisotropic two-dimensional windows filtering.

Imaging methods permitting real-time, wide-field, and quantitative optical mapping of biological tissue properties offer an unprecedented range of applications for clinical use. Following the development of spatial frequency domain imaging, we introduce a real-time demodulation method called single snapshot of optical properties (SSOPs). However, since this method uses only a single image to generate absorption and reduced scattering maps, it was limited by a degraded image quality resulting in artifacts that diminished its potential for clinical use.

Real-time, wide-field, and quantitative oxygenation imaging using spatiotemporal modulation of light.

Quantitative diffuse optical imaging has the potential to provide valuable functional information about tissue status, such as oxygen saturation or blood content to healthcare practitioners in real time. However, significant technical challenges have so far prevented such tools from being deployed in the clinic. Toward achieving this goal, prior research introduced methods based on spatial frequency domain imaging (SFDI) that allow real-time (within milliseconds) wide-field imaging of optical properties but at a single wavelength.

Towards sensitive, high-throughput, biomolecular assays based on fluorescence lifetime.

Time-resolved fluorescence detection for robust sensing of biomolecular interactions is developed by implementing time-correlated single photon counting in high-throughput conditions. Droplet microfluidics is used as a promising platform for the very fast handling of low-volume samples. We illustrate the potential of this very sensitive and cost-effective technology in the context of an enzymatic activity assay based on fluorescently-labeled biomolecules.

High-dynamic-range microscope imaging based on exposure bracketing in full-field optical coherence tomography.

By applying the proposed high-dynamic-range (HDR) technique based on exposure bracketing, we demonstrate a meaningful reduction in the spatial noise in image frames acquired with a CCD camera so as to improve the fringe contrast in full-field optical coherence tomography (FF-OCT). This new signal processing method thus allows improved probing within transparent or semitransparent samples. The proposed method is demonstrated on 3 μm thick transparent polymer films of Mylar, which, due to their transparency, produce low contrast fringe patterns in white-light interference microscopy.

Impact of laser phase and amplitude noises on streak camera temporal resolution.

Streak cameras are now reaching sub-picosecond temporal resolution. In cumulative acquisition mode, this resolution does not entirely rely on the electronic or the vacuum tube performances but also on the light source characteristics. The light source, usually an actively mode-locked laser, is affected by phase and amplitude noises.

High-throughput time-correlated single photon counting.

We demonstrate time-correlated single photon counting (TCSPC) in microfluidic droplets under high-throughput conditions. We discuss the fundamental limitations in the photon acquisition rate imposed by the single photon detection technique and show that it does not preclude accurate fluorescence lifetime (FLT) measurements at a droplet throughput exceeding 1 kHz with remarkable sensitivity. This work paves the way for the implementation of innovative biomolecular interaction assays relying on the FLT detection of nanosecond-lived fluorophores for high-throughput biotechnological applications, including high-throughput screening or cell sorting potentially allowed by droplet microfluidics or other fast sample handling facilities.

Streak camera: a multidetector for diffuse optical tomography.

We describe an experimental setup for time-resolved diffuse optical tomography that uses a seven-channel light guide to transmit scattered light to a streak camera. This setup permits the simultaneous measurement of the time profiles of photons reemitted at different boundary sites of the objects studied. The instrument, its main specifications, and detector-specific data analysis before image reconstruction are described.