Publications by authors named "Ugur Tunc"
Elevated Anti-Cyclic Citrullinated Peptide Levels Associated with Filamentary Keratitis.
Ocul Immunol Inflamm
December 2024
Article Synopsis
- A study was conducted to evaluate two cases of filamentary keratitis in patients with high levels of anti-CCP antibodies, typically associated with rheumatoid arthritis (RA), but without prior RA diagnosis.
- The first patient, a 77-year-old man, showed no development of RA over three years, while the second patient, an 84-year-old man, developed RA 16 months after presenting with severe eye symptoms.
- The findings suggest that elevated anti-CCP levels in patients with filamentary keratitis might be an early indicator of RA, highlighting the need for further research on the connection between anti-CCP antibodies and eye conditions in RA.
Purpose: To compare the outcomes of intravitreal dexamethasone implant used as either an adjuvant or a switching therapy for diabetic macular edema in patients with poor anatomic response after three consecutive monthly injections of ranibizumab.
Methods: This retrospective study included patients with diabetic macular edema who received three consecutive doses of ranibizumab as initial therapy and demonstrated poor response. A single dose of intravitreal de xamethasone implant was administered to these patients.
Article Synopsis
- A study was conducted to evaluate the Eyecryl toric phakic IOL (pIOL) for patients with moderate-to-high myopic astigmatism, focusing on visual and refractive outcomes over three years.
- The research included 52 eyes from 28 patients, showing a significant improvement in visual acuity and reduction in astigmatism, with 70% of eyes achieving better vision versus preoperative levels.
- The findings indicate that the Eyecryl toric pIOL is effective and safe, though some patients experienced minor complications, such as cell loss and opacification issues.
Purpose: To report the effect of topical application of recombinant human nerve growth factor (rhNGF) eye drops on corneal epithelial regeneration in patients with refractory epitheliopathy.
Methods: A retrospective chart review was conducted on patients treated with topical rhNGF for refractory epithelial keratopathy due to stage I neurotrophic keratitis (NK). Data regarding demographics and ocular/systemic past medical history was extracted from patient charts.
Objectives: The objectives of the study were to evaluate the vascular and stromal structure of the choroid in patients with inactive thyroid associated orbitopathy (TAO) by measuring choroidal vascularity index (CVI) and choroidal thickness (CT) using enhanced depth imaging (EDI) optical coherence tomography (OCT).
Methods: The choroidal image was taken with EDI mode spectral domain (SD)-OCT. All scans were taken between 9.
Purpose: To investigate the corneal bacterial microbiome in patients with keratoconus using next-generation sequencing and develop a new perspective on the pathogenesis of the disease.
Methods: This prospective observational study included 10 patients with keratoconus who underwent corneal crosslinking procedure and 10 healthy controls who underwent photorefractive keratectomy. Patients included in the study were aged 18 years or older.
Purpose: To evaluate long-term visual and refractive outcomes of corneal wavefront-guided transepithelial photorefractive keratectomy (t-PRK) with mitomycin C for the treatment of corneal opacities secondary to adenoviral epidemic keratoconjunctivitis.
Methods: Records of patients who underwent corneal wavefront-guided t-PRK with excimer laser from January 2012 to December 2018 were retrospectively reviewed. Preoperative and postoperative uncorrected visual acuity, best-spectacle corrected visual acuity, slit-lamp biomicroscopic examination findings, manifest refraction, and corneal aberrations and fundus examination findings were evaluated.
Purpose: To evaluate the effect of topical omega 3 on ocular surface following corneal crosslinking (CXL) in keratoconus and compare with topical sodium hyaluronate.
Material Methods: 50 patients who underwent CXL were divided into two groups. In addition to topical steroids and antibiotics, Group A was prescribed topical omega 3; Group B was prescribed 0.
Objective: The objective of this study is to evaluate the repeatability and reliability of corneal parameters in different stages of keratoconus patients using a combined Scheimpflug-Placido disc analysis system.
Materials And Methods: In this prospective study, three consecutive measurements were performed by the same observer using Scheimpflug-Placido disc anterior segment analysis device in keratoconus patients. Flattest and steepest simulated keratometry and corneal volume, corneal aberrations, thinnest corneal thickness, symmetry index, keratoconus vertex and Baiocchi-Calossi-Versaci index were recorded.
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
View Article and Find Full Text PDFPurpose: To investigate choroidal vascular index (CVI) in eyes with nanophthalmos (NO) with the use of optical coherence tomography (OCT).
Methods: Macular enhanced depth imaging OCT scans of 25 eyes of 25 patients with NO and age-gender-matched 25 eyes of 25 control subjects were analysed. Images were binarized using the ImageJ software, and total choroid area (TCA), luminal area (LA) and stromal area (SA) were acquired.
Serum calcium, magnesium, phosphorus, and vitamin D in benign essential blepharospasm.
Graefes Arch Clin Exp Ophthalmol
June 2020
Purpose: This study aims to compare serum calcium, magnesium, phosphorus, and 25-hydroxy (OH)-vitamin D levels in patients with benign essential blepharospasm (BEB) and healthy subjects and to determine their association with disease severity and frequency.
Methods: This is a prospective study conducted in a tertiary care hospital. Fifty patients (female, 39; male, 11) with BEB and 22 healthy subjects (female, 15; male, 7) included in the study.
Retinal microvasculature in the remission period of Behcet's uveitis.
Photodiagnosis Photodyn Ther
March 2020
Purpose: To evaluate retinal microvasculature and blood flow during Behcet's uveitis (BU) remission via optical coherence tomography angiography (OCT-A), and compare the results with those from healthy eyes.
Methods: A total of 35 eyes of 35 BU patients presenting during the remission period of BU involving the posterior segment were enrolled, as were 30 normal eyes of 30 age and sex-matched healthy participants. Optical coherence tomography angiograms were analyzed.
Article Synopsis
- Patients with diabetic macular edema may not achieve optimal results with monthly ranibizumab injections, leading to consideration of corticosteroid implants as an alternative treatment.
- The study compared outcomes between two patient groups: those who switched to an intravitreal dexamethasone implant after three (early-switch group) versus six (late-switch group) consecutive monthly injections of ranibizumab due to inadequate response.
- Results showed that while both groups had similar improvements in visual acuity and retinal thickness by 3, 9, and 12 months, the early-switch group had significantly better outcomes at 6 months, indicating that switching sooner may be more beneficial.