Radio-Anatomical Assessment of Cerebellum Volume in Individuals with Alzheimer's Disease.

Introduction: Alzheimer's disease is a chronic brain disease that includes memory and language disorders. This disease, which is considered the most common cause of dementia worldwide, accounts for 60-80% of all dementia cases. Recent studies suggest that the cerebellum may play a role in cognitive functions as well as motor functions.

Agri-Food and Food Waste Lignocellulosic Materials for Lipase Immobilization as a Sustainable Source of Enzyme Support-A Comparative Study.

Enzyme immobilization is a crucial method in biotechnology and organic chemistry that significantly improves the stability, reusability, and overall effectiveness of enzymes across various applications. Lipases are one of the most frequently applied enzymes in food. The current study investigated the potential of utilizing selected agri-food and waste materials-buckwheat husks, pea hulls, loofah sponges, and yerba mate waste-as carriers for the immobilization of Sustine 121 lipase and yeast biomass as whole-cell biocatalyst and lipase sources.

Dendritic/antigen presenting cell mediated provision of T-cell receptor gamma delta (TCRγδ) expressing cells contributes to improving antileukemic reactions ex vivo.

T-cell receptor gamma delta (TCRγδ) expressing T-cells are known to mediate an MHC-independent immune response and could therefore qualify for immune therapies. We examined the influence of dendritic cells(DC)/antigen presenting cell (APC) generated from blast-containing whole blood (WB) samples from AML and MDS patients on the provision of (leukemia-specific) TCRγδ expressing T-cells after mixed lymphocyte culture (MLC). Kit-M (granulocyte-macrophage colony-stimulating factor (GM-CSF) + prostaglandin E1 (PGE1)) or Kit-I (GM-CSF + Picibanil) were used to generate leukemia derived APC/DC (DC)from WB, which were subsequently used to stimulate T-cell enriched MLC.

The Morphometric Analysis of the Ethmoid Roof for Endoscopic Sinus Surgery With Multidetector Computed Tomography.

Most potential major complications in endoscopic sinus surgery are related to the ethmoid bone. To prevent complications, it is necessary to define the concept of a "dangerous ethmoid." The coronal multidetector computed tomography (MDCT) scans of a total of 271 patients, including 101 patients under 18 years old and 170 patients over 18 years old, were examined.

Morphometric Analysis of Corpus Callosum in Individuals with Alzheimer's Disease: Magnetic Resonance Imaging (MRI) Study.

Introduction: The Corpus Callosum (CC) is the largest commissural tract in the nervous system. Few studies have examined the extent of CC in Alzheimer's disease (AD) patients, and these studies have reported conflicting findings.

Materials And Methods: The study was performed using 176 brain MRI images of 88 Alzheimer's patients (55 women-32 men) and 88 healthy individuals (44 women-44 men).

Importance of CD71 Erythrocyte Cell Levels in Prognosis in Patients With β-Thalassemia.

Background/objectives: CD71 erythroid cells (CECs) are immature red blood cells (proerythroblasts, erythroblasts, and reticulocytes). CECs play an important role in the development of sepsis and cancer by causing immunosuppression. We examined the CEC levels in the peripheral blood of beta thalassemia (βThal) patients and investigated the relationship between CECs and the clinical status of the patients, especially splenectomy.

Effects of Splenectomy on Natural Killer Cell Levels in β-Thalassemia Major Patients.

Aim: In this study, we investigated how splenectomy affects natural killer (NK) cell levels in patients with β-thalassemia major (β-TM).

Materials And Methods: Seventy patients with β-TM (38 splenectomized and 32 nonsplenectomized) and 25 healthy controls were included in this study. The hemogram parameters, ferritin, T lymphocyte, T-helper cell, T-suppressor cell, and NK cell numbers, were measured.

CASUS and APACHE II score in predicting mortality after coronary artery bypass grafting.

Background: This study aims to compare Cardiac Surgery Score (CASUS) and the Acute Physiology and Chronic Health Evaluation (APACHE II) scoring systems for predicting mortality in patients undergoing isolated coronary artery bypass grafting.

Methods: Between January 2019 and March 2019, a total of 204 patients (166 males, 38 females; mean age: 60.5±0.

The power of mechanical ventilation may predict mortality in critically ill patients.

Background: Mechanical power (MP) is the amount of energy transferred from the ventilator to the patient within a unit of time. It has been emphasized in ventilation-induced lung injury (VILI) and mortality. However, its measurement and use in clinical practice are challenging.

Dendritic Cell-Triggered Immune Activation Goes along with Provision of (Leukemia-Specific) Integrin Beta 7-Expressing Immune Cells and Improved Antileukemic Processes.

Integrin beta 7 (β7), a subunit of the integrin receptor, is expressed on the surface of immune cells and mediates cell-cell adhesions and interactions, e.g., antitumor or autoimmune reactions.

Assessment of relative translucency and resultant color of contemporary resin-matrix ceramics indicated for laminate veneers and full crowns.

Background And Aims: Evaluation of the optical properties of restorative materials is an important parameter for identifying clinical success. The aim of this study was to compare the translucency of contemporary resin-matrix ceramics (RMCs) and to evaluate the effect of cement shade on the final color of RMCs indicated for laminate veneers and full crowns.

Materials And Methods: A hundred A2 shade RMC specimens were fabricated by using Mazic Duro (MD), CAMouflage NOW (CN), KZR-CAD HR2 (KZR), Grandio Block (GB), and Brilliant Crios (BC) at 0.

Immunomodulatory kits generating leukaemia derived dendritic cells do not induce blast proliferation ex vivo: IPO-38 as a novel marker to quantify proliferating blasts in acute myeloid leukaemia.

(Leukaemia derived) dendritic cells (DC, DC) are potent stimulators of anti-leukaemic activity in acute myeloid leukaemia (AML) and can be generated with immunomodulatory kits containing granulocyte-macrophage-colony-stimulating-factor (GM-CSF), prostaglandin-E (PGE), prostaglandin-E (PGE) and/or picibanil (OK-321). Potential adverse effects initiated through kits, especially the proliferation of blasts, must be ruled out to ensure treatment safety. We quantified proliferating blasts with the proliferation markers CD71 and Ki-67 and the novel proliferation marker IPO-38 before and after kit treatment ex vivo.

B cell depletion in patients with rheumatoid arthritis is associated with reduced IL-1β in GCF.

Objectives: We evaluated the effect of B cell depletion on the clinical periodontal findings and IL-1β and MMP-8 levels of the gingival crevicular (GCF) fluid in patients with rheumatoid arthritis (RA).

Materials And Methods: Seventy patients were included in this case-control study. Twenty patients with RA were undergoing B-cell depletion treatment.

Interferon Gamma Secretion of Adaptive and Innate Immune Cells as a Parameter to Describe Leukaemia-Derived Dendritic-Cell-Mediated Immune Responses in Acute Myeloid Leukaemia in vitro.

Introduction: Myeloid leukaemic blasts can be converted into leukaemia-derived dendritic cells (DC), characterised by the simultaneous expression of dendritic- and leukaemia-associated antigens, which have the competence to prime and enhance (leukaemia-specific) immune responses with the whole leukaemic antigen repertoire. To display and further specify dendritic cell (DC)- and DC-mediated immune responses, we analysed the interferon gamma (IFNy) secretion of innate and adaptive immune cells.

Methods: DC/DC were generated from leukaemic whole blood (WB) with (blast)modulatory Kit-I (granulocyte-macrophage colony-stimulating factor [GM-CSF] + Picibanil [OK-432]) and Kit-M (GM-CSF + prostaglandin E1) and were used to stimulate T cell-enriched immunoreactive cells.

Evaluating the X-ray-Shielding Performance of Graphene-Oxide-Coated Nanocomposite Fabric.

Exposure to ionizing radiation (IR) during diagnostic medical procedures brings certain risks, especially when experiencing recurrent exposures. The fabrication of nano-based composites, doped with different nanoparticles, have been suggested as effective shielding materials to replace conventional lead-based ones in material sciences and nanotechnology. In this study, commercially available fabrics, used to produce scrubs and gowns for clinical staff, are modified utilizing graphene oxide (GO) nanoparticles using a layer-by-layer (LBL) technique.

Effects of Exercise on Resilience, Insight and Functionality in Patients with Chronic Schizophrenia in a Psychiatric Nursing Home Setting: A Randomized Controlled Trial.

To our knowledge, there are no studies on the effects of exercise in patients with severe schizophrenia-related disability or in nursing home settings. Again, the literature search on the influence of exercise on insight and resilience gives no results except mind-body exercises. The aim of this study was to investigate the effects of exercise on psychotic symptoms, depression, functionality, insight and resilience in patients with severe schizophrenia-related disability living in nursing home setting.

1,3-Disubstituted urea derivatives: Synthesis, antimicrobial activity evaluation and in silico studies.

The development of new antimicrobial compounds is in high demand to overcome the emerging drug resistance against infectious microbial pathogens. In the present study, we carried out the extensive antimicrobial screening of disubstituted urea derivatives. In addition to the classical synthesis of urea compounds by the reaction of amines and isocyanates, we also applied a new route including bromination, oxidation and azidination reactions, respectively, to convert 2-amino-3-methylpyridine to 1,3-disubstituted urea derivatives using various amines.

Appropriate use of tocilizumab in COVID-19 infection.

Objective: This study aimed to describe the effectiveness and optimum use of tocilizumab (TCZ) treatment by the support of clinical, laboratory and radiologic observations.

Methods: All patients were followed up in the hospital with daily interleukin-6 (IL-6), C-reactive protein (CRP), ferritin, d-dimer, full blood count, and procalcitonin. Thoracic computed tomography (CT) was performed on admission, when oxygen support was necessary, and seven days after TCZ started.

Study of structural, elastic, electronic, and vibrational properties of MRhO (M = Cd and Zn) spinels: DFT-based calculations.

Solar-assisted water splitting using photoelectrochemical cells (PECs) is one of the promising ways for the production of hydrogen to store renewable energy. Semiconducting materials are used as a key factor which controls the overall energy conversion efficiency in PECs. However, finding new semiconductors with appropriate properties (stability, efficient charge separation and transport, abundant and visible light absorption) is still a challenge for developing new materials for solar water splitting.

Pressure induced phase transition, electronic and optical properties of LiBeX (XAs, Sb and Bi).

In this contribution, we report the results of theoretical calculation on the pressure induced phase transitions, structural, electronic and optical properties of the lithium based ternary LiBeX (X = As, Sb, Bi) compounds. These calculations are carried out using the full potential linearized augmented plane wave method. Our results show that these compounds undergo first order phase transitions.

Prednisolone-Induced Hairy Tongue: A Case Report.

Hairy tongue is a benign and mostly asymptomatic disorder characterized by elongation of papillae with typical hairy-like appearance on the dorsal surface of the tongue. Many medical conditions, antibiotics, and drugs inducing xerostomia are associated with hairy tongue. In this article, we report a female patient with polymyalgia rheumatica who developed hairy tongue following treatment with prednisolone.

Phase transitions and lattice dynamics in perovskite-type hydride [Formula: see text].

First principles calculations have been used to investigate the structural phase transitions and lattice dynamics in the alloy [Formula: see text]. The density functional perturbation theory and the virtual crystal approximation are employed, within the generalized gradient approximation. Our total energy and formation enthalpy results show that [Formula: see text] undergoes a phase transition from the orthorhombic Pnma phase to the polar R3c one at a lithium concentration of x  =  0.

First principles investigations of the structural, elastic, vibrational, and thermodynamic properties of TiMgO oxide spinels: cubic and tetragonal phases.

In the present study ab initio methology under density functional theory with generalized gradient approximation is used to study the structural, elastic, and vibrational properties of TiMgO with cubic and tetragonal phases with space groups (Fd[Formula: see text]m) and P4_122, respectively. The present study shows that the studied compound TiMgO is mechanically stable in both phases. Both phases have ductile nature and strong anisotropic properties, and it is also observed that the tetragonal phase has more anisotropic properties compared to the cubic phase.

Can the Second to Fourth Digit Ratio (2D : 4D) Be a Marker to Determine Ankylosing Spondylitis Disease Activity?

Objective: The length ratio of the index finger (2D) to the ring finger (4D) (2D : 4D ratio) is considered a biomarker of prenatal sex hormone exposure. The 2D : 4D ratio is influenced by prenatal androgen and estrogen levels. Because ankylosing spondylitis (AS) influences men more frequently and severely than women, androgens are proposed to be related to AS pathogenesis.

Effects of dam and seqA genes on biofilm and pellicle formation in Salmonella.

In this study, the effects of dam and seqA genes on the formation of pellicle and biofilm was determined using five different Salmonella serovars S. Group C1 (DMC2 encoded), S. Typhimurium (DMC4 encoded), S.