The study investigates how phenytoin, a medication, affects the healing of colorectal anastomoses in rats, focusing on different application methods: intraperitoneal, oral, and rectal.
It measures the impact of phenytoin on gene expressions related to healing and compares bursting pressure and tissue examination results between treated and control rats.
Findings reveal that phenytoin application significantly increases anastomotic bursting pressure and enhances expression of genes involved in healing, particularly FGF2 and TGF-β, indicating potential benefits for improving recovery following colonic surgery.