[Viral inclusions of sarcoid granuloma into the epitheliocytes].

Electron microscopy was used study the cellular composition of sarcoid granulomas in the lung of 10 patients. In 4 patients, epithelioid cells contained herpes virus virions. In these patients, the disease clinically began acutely, ran along with erythema nodosum; their treatment involved glucocorticosteroids.

[Morphometrical assessment of the tuberculous cavern structure in tobacco smokers].

527 patients of the lung disease hospital filled in questionnaires. Cavernal walls of 22 patients with fibrocavernous lung tuberculosis were studied morphometrically. Among patients with tuberculosis 21.

[Prevalence of tobacco smoking among phthisio-pulmonological inpatients].

A questionnaire survey of 222 phthisiopulmonological inpatients has indicated that 21.7 of the males and 4.05% of the females are smokers.

[Interorgan relationships in alcoholic intoxication].

It is suggested, on the basis of 315 necropsies of patients who died of drunkenness and alcoholism and examination of 300 rats with acute and chronic alcoholic intoxication, to distinguish an "alcoholic disease" as a separate nosological entity. The stages of this disease are drunkenness, alcoholism and alcoholic abstinence syndrome. Multiple organ pathology is characteristic for the disease with obligatory microangiopathy, alcoholic encephalo-, cardiomyo- and hepatopathy.

[Myocardial damage and the sympatho-adrenal system in ethanol abstinence syndrome in rats].

Increase in content of II-oxycorticosteroids and in activity of dopamine-beta-hydroxylase in blood serum, decrease in concentration of adrenaline in adrenal glands with simultaneous accumulation of the catecholamine in myocardium were observed in rats after intensive alcoholization within 5 days (intragastric administration of ethanol 4-5 g/kg twice daily). In this case content of noradrenaline and its density in the catecholamine-containing nervous fibers were decreased. Ethanol abolishing, as shown by dynamics of catecholamines in heart and adrenal glands, caused an additive stimulation of the sympathoadrenal system, which reached the maximal level within a day and accomplished within 3 days after the last ethanol injection.

Morphofunctional examination of the heart in rats with the alcohol withdrawal syndrome.

Using histochemical methods, light and electron microscopy, authors examined rat heart 2-6 hours, 1, 3, and 7 days after discontinuation of forced intoxication with alcohol. At the same time, they assessed the contractile function and creatine phosphokinase (CPK) activity in the isolated perfused heart, and the development of animal destruction. Ethanol withdrawal was followed by escalation of vascular disorders in the heart, dystrophic changes in the subcellular structures, considerable polymorphism in enzyme distribution and activity, and formation of foci containing disintegrating myocytes with contractures.

[Participation of catecholamines in the mechanism of heart damage during the alcohol withdrawal syndrome in rats].

Withdrawal syndrome in rats was induced after ethanol administration in a dose of 4-5 g/kg b. w. twice daily for 5 consecutive days.

[Contractile function, glucose consumption and lactate release by the isolated rat heart during different regimens of alcohol administration and after discontinuation of ethanol].

Acute or chronic intoxication of rats with ethanol (intragastric administration at a dose of 8 g/kg or free-choice drinking of 10% ethanol for 3 months) produced no significant changes in contractile function, glycogen content, glucose uptake and lactate release in isolated hearts. Withdrawal syndrome simulated in rats following a short period of severe intoxication with ethanol at a dose of 4-5 g/kg twice daily has demonstrated a 15 and 28% decrease in peak systolic pressure and tension time index, respectively. In this case glucose uptake and lactate release were 2 times higher.

[Alcoholic lesions of the brain].

Brains of 117 alcoholics admitted in the state of alcoholic coma or abstinence syndrome with an increase of blood pressure or development of acute psychosis were studied. The changes in the human brain were compared with those occurring in the brains of 30 rats with chronic alcoholic intoxication and formation of withdrawal syndrome. It is shown that in alcoholic coma and different manifestations of abstinence syndrome vascular and cellular changes take place, that can be attributed to the action of ethanol or its metabolites, as well as catecholamines.

[Pathologicoanatomic diagnosis of alcoholism].

Using their own and literature data the authors describe morphological alterations of the brain, heart, lungs, liver, stomach, pancreas and kidneys with the aim of the pathology diagnosis of chronic alcoholism and other types of alcoholic intoxication. The approximate diagnoses in various types of alcoholic intoxication are given as well as some rules of the pathology diagnosis coding.

[Morphology of the brain and heart in alcoholic psychoses].

The authors studied the brain and heart of 40 patients (30 males and 10 females) who were hospitalized with the clinical diagnosis of alcoholic delirium, Gaye-Wernike's encephalopathy, and acute alcoholic intoxication due to chronic alcoholism. The morphological alterations in the brain and heart were as follows: compromised vascular permeability, dystrophic changes in the neurons and cardiomyocytes, proliferative reaction of microgliocytes and the development of small cardiosclerosis. Such disorders can be defined as an exacerbation of chronic alcoholic encephalopathy and cardiomyodystrophy.

[Myocardium in acute and chronic experimental alcoholic intoxication].

The myocardium of both heart ventricles in acute (AAP) and chronic (CAP) alcoholic poisoning was studied in 90 randombred rats. Functional-morphological changes typical of alcoholic cardiomyodystrophy were shown to develop in the heart in AAP and CAP. In AAP, alcoholic cardiomyodystrophy may lead to acute cardiac insufficiency and in CAP to progressive reduction of the contractile function of the heart and disturbances of conductivity in it.

[Experimental protection of the myocardium from anoxic damage by a weak solution of formalin].

Experiments on 80 noninbred rats and 135 rabbits have demonstrated for the first time the possibility of cardioplegia induction with a 0.25% formaldehyde solution. In experimental heterotopic heart transplantation, cardiac function could be restored by perfusion of donor blood within up to 3 hours after cardioplegia.