Publications by authors named "Ugo Sardo"
As a functional component of erythrocyte hemoglobin, iron is essential for oxygen delivery to all tissues in the body. The liver-derived peptide hepcidin is the master regulator of iron homeostasis. During anemia, the erythroid hormone erythroferrone regulates hepcidin synthesis to ensure the adequate supply of iron to the bone marrow for red blood cell production.
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- Streptococcus pneumoniae is an opportunistic pathogen that can cause serious diseases following asymptomatic colonization in the upper respiratory tract, with inflammation and neutrophil recruitment serving as key defenses.
- The study focuses on how serine proteases from neutrophils can degrade a signaling peptide called CSP, which is crucial for the bacterium's natural competence—the ability to gain genetic material and adapt.
- Results show that when CSP is degraded by serine proteases, it significantly reduces the pneumococcus's competence and genetic exchange, highlighting a new way the host immune response can influence bacterial behavior.
Unlabelled: As a functional component of erythrocyte hemoglobin, iron is essential for oxygen delivery to all tissues in the body. The liver-derived peptide hepcidin is the master regulator of iron homeostasis. During anemia, the erythroid hormone erythroferrone regulates hepcidin synthesis to ensure adequate supply of iron to the bone marrow for red blood cells production.
View Article and Find Full Text PDFErythropoietin (EPO) acts on erythroid progenitor cells to promote their survival and differentiation to mature erythrocytes. Along with this canonical role, EPO is also reported to modulate energy metabolism, resulting in improved glucose tolerance and insulin sensitivity. EPO also stimulates the production of the hormone erythroferrone (ERFE) which acts to suppress hepcidin production, thus increasing dietary iron absorption and mobilizing stored iron for use in erythropoiesis.
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