Targeting c-Met in breast cancer: From mechanisms of chemoresistance to novel therapeutic strategies.

Breast cancer presents a significant challenge due to its heterogeneity and propensity for developing chemoresistance, particularly in the triple-negative subtype. c-Mesenchymal epithelial transition factor (c-Met), a receptor tyrosine kinase, presents a promising target for breast cancer therapy due to its involvement in disease progression and poor prognosis. However, the heterogeneous expression of c-Met within breast cancer subtypes and individual tumors complicates targeted therapy.

Chemical profiling, toxicity assessment, anti-diarrhoeal, anti-inflammatory and antinociceptive activities of Canarium schweinfurthii Engl. (Burseraceae) bark in rats.

Ethnopharmacological Relevance: The bark of Canarium schweinfurthii is used in ethnomedicine for the treatment of diabetes, pain, malaria, fever and diarrhoea.

Aim Of The Study: The chemical phytoconstituents, antidiarrheal, anti-inflammatory and antinociceptive effects and safety profile of the aqueous extract of Canarium schweinfurthii bark (AECSB) were investigated.

Materials And Methods: Gas chromatography-mass spectrometry (GC-MS) was used to analyse the phytochemical composition.

Phytochemical profiling, toxicity studies, wound healing, analgesic and anti-inflammatory activities of Musa paradisiaca L. Musaceae (Plantain) stem extract in rats.

Ethnopharmacological Relevance: The stem of Musa paradisiaca (plantain) has found application in traditional medicine for the treatment of diabetes, inflammation, ulcers and wound injuries.

Aim Of The Study: This study investigated the phytochemical composition, toxicity profile, wound healing, anti-inflammatory and analgesic effects of aqueous Musa paradisiaca stem extract (AMPSE) in rats.

Methods: Phytochemical analysis of methanol-MPSE was performed by gas chromatography-mass spectrometry (GC-MS).

Phytochemical characterization, anti-diarrhoeal, analgesic, anti-inflammatory activities and toxicity profile of Ananas comosus (L.) Merr (pineapple) leaf in albino rats.

Ethnopharmacological Relevance: Ananas comosus (pineapple) leaf is used in ethnomedicine to treat diarrhoea, inflammation, pain, bacterial infections and oedema.

Aim Of The Study: The aim of this study was to investigate the anti-diarrhoeal, anti-inflammatory and analgesic effects as well as the toxicity profile of the aqueous Ananas comosus leaf extract (AACLE) in rats.

Methods: Methanol ACLE was subjected to gas chromatography-mass spectrometry (GC-MS) analysis.

Phytochemical composition, toxicological profiling and effect on pup birth weight of Corchorus olitorius leaf extract in rats: Implications for fetal macrosomia control.

Ethnopharmacological Relevance: Corchorus olitorius is used in ethnomedicine to arrest threatened miscarriage, ease labour, and promote smooth childbirth.

Aim Of The Study: To evaluate the phytochemical composition, toxicity profile, and effect of Corchorus olitorius L. leaf extract (COLE) on fetal macrosomia control in rats.

Bioactive Phytoconstituents and Their Therapeutic Potentials in the Treatment of Haematological Cancers: A Review.

Haematological (blood) cancers are the cancers of the blood and lymphoid forming tissues which represents approximately 10% of all cancers. It has been reported that approximately 60% of all blood cancers are incurable. Despite substantial improvement in access to detection/diagnosis, chemotherapy and bone marrow transplantation, there is still high recurrence and unpredictable but clearly defined relapses indicating that effective therapies are still lacking.

Phytochemical composition, bioactive properties, and toxicological profile of Tetrapleura tetraptera.

The use of medicinal plants has gained renewed wide popularity in Africa, Asia, and most parts of the world because of the decreasing efficacy of synthetic drugs. Thus, natural products serve as a potent source of alternative remedy. Tetrapleura tetraptera is a medicinal plant with cultural and traditional significance in West Africa.

A review on the traditional uses, phytochemistry, and pharmacological activities of clove basil ( L.).

In traditional medicine, (clove basil) is used in the treatment of various diseases such as diabetes, cancer, inflammation, anaemia, diarrhoea, pains, and fungal and bacterial infections. The present study reviewed the phytochemicals, essential oils, and pharmacological activities of . The bioactive compounds extracted from include phytochemicals (oleanolic acid, caffeic acid, ellagic acid, epicatechin, sinapic acid, rosmarinic acid, chlorogenic acid, luteolin, apigenin, nepetoidin, xanthomicrol, nevadensin, salvigenin, gallic acid, catechin, quercetin, rutin, and kaempfero) and essential oils (camphene, β-caryophyllene, α- and β-pinene, α-humulene, sabinene, β-myrcene, limonene, 1,8-cineole, trans-β-ocimene, linalool, α- and δ-terpineol, eugenol, α-copaene, β-elemene, p-cymene, thymol, and carvacrol).

leaf extract ameliorates phenylhydrazine-induced anaemia and toxicity in Wistar rats.

Objectives: L. is used in traditional medicine for the treatment of bacterial infections and anaemia. This study was designed to evaluate the effect of leaf extract on phenylhydrazine (PHZ)-induced anaemia and toxicity in rats.

leaf extract improves gastrointestinal functions in rats and rabbits: an implication for ulcer and diarrhoea management.

Purpose: L. (Family, Myrtaceae) is reportedly used in ethnomedicine for the treatment of diarrhoea, inflammation, and gastroenteritis.

Objective: This study evaluated the gastrointestinal function of leaf extract (PGLE) in rats and rabbits.

studies on the ameliorative effect of coconut water against carbon tetrachloride induced toxicity in rats.

Purpose: Coconut water is used in folklore medicine for oral rehydration, treatment of childhood diarrhoea, gastroenteritis and cholera, and is also known to possess antioxidant properties.

Objective: In this study, we examined the ameliorative potentials of coconut water on carbon tetrachloride (CCl) induced toxicity in rats.

Materials And Methods: Rats were randomly assigned into separate cages according to the sex of 5 groups.

Corrigendum to "The potential health benefits of dietary natural plant products in age related eye diseases" [Heliyon 6 (7) (2020) e04408].

[This corrects the article DOI: 10.1016/j.heliyon.

leaf extract ameliorates phenylhydrazine-induced anaemia and toxicity in Wistar rats.

Objectives: L. is used in traditional medicine for the treatment of bacterial infections and anaemia. This study was designed to evaluate the effect of leaf extract on phenylhydrazine (PHZ)-induced anaemia and toxicity in rats.

Effect of Quarrying and Stone Crushing Activities on Nutritional Composition, Heavy Metals and Oxidative Stress Indices of .

Background And Objective: Physiological and biochemical changes in plants are indicators used for monitoring cellular activity of plant prior and post exposure to harsh environment. This study investigated the impact of quarrying and stone crushing activities on heavy metals, plant nutritional composition, phytochemicals and oxidative stress indices of Aspilia africana.

Materials And Methods: Different parts of A.

The potential health benefits of dietary natural plant products in age related eye diseases.

In the past decade, there has been a tremendous increase in the number of cases of age-related eye diseases such as age-related macular degeneration (AMD), cataract, diabetic retinopathy and glaucoma. These diseases are the leading causes of visual impairment and blindness all over the world and are associated with many pathological risk factors such as aging, pollution, high levels of glucose (hyperglycaemia), high metabolic rates, and light exposure. These risk factors lead to the generation of uncontrollable reactive oxygen species (ROS), which causes oxidative stress.

Ameliorative effect of aqueous leaf extract of on phenylhydrazine-induced anaemia and toxicity in rats.

is used in ethnomedicine for the treatment of overweight, constipation and anaemia. This study evaluated the ameliorative effect of aqueous leaf extract of on phenylhydrazine-induced anaemia in rats. Acute toxicity was determined in male and female rats (n = 5/group/sex) by oral administration of single dose of up to 5000 mg/kg of the extract.

Haematoprotective and red blood cell membrane stabilizing effects of Justicia carnae leaf extracts in sodium nitrate-treated rats.

Objectives Traditionally, Justicia carnae is used in treatment of anaemia. In this study, the haematoprotective effects of ethanol and aqueous leaf extracts of J. carnae were evaluated in sodium nitrate-treated male rats.

Evaluating bioactive constituents and toxicological effects of aqueous extract of fermented seeds in rats.

Objective: This study aimed at evaluating the bioactive constituents and the toxicological profile of the aqueous fermented seed extract of .

Materials And Methods: The chemical constituents of fermented were assessed using GC-MS. For acute toxicity study, one-time doses of up to 5000 mg/kg of the extract were orally administered to male and female rats whereas 200, 400 and 800 mg/kg of the extract were orally administered daily for 14 days in sub-acute toxicity investigation.

Toxicological Evaluation of Phytochemical Characterized Aqueous Extract of Wild Dried (Mont.) Mushroom in Rats.

(Mont.) is an edible wild mushroom with tough fruiting body that belongs to the family Polyporaceae. It is used in ethnomedicine for the treatment of ulcer, anaemia, cough and fever.

Safety Evaluation of an Aqueous Extract of Termitomyces robustus (Agaricomycetes) in Wistar Rats.

Termitomyces robustus is an edible and highly nutritious wild Basidiomycetes mushroom. It is used in ethnomedicine for treating malnutrition-related diseases, rheumatism, diarrhea, gonorrhea, anemia, and hypertension. Despite the tremendous use of this delicious edible mushroom as a source of nutrients, no comprehensive literature describes its safety and toxicity profiles.

Toxicological profile of the aqueous-fermented extract of in rats.

Objective: This study was conducted to assess the toxicity profile of the aqueous-fermented extract of in rats.

Materials And Methods: In acute toxicity test, the rats of different groups were orally administered with a single dose of 500, 1000, 2000 and 5000 mg/kg of fermented extract of . The rats were monitored for behavioral changes, toxicity signs and mortality.

Sensitivity of Coriandrum sativum extract on bacterial pathogens isolated from digestive system of rabbits, and its role on in vitro cecal gas production and fermentation.

The present context was aimed to investigate the antibacterial potency of aqueous extract of coriander (Coriandrum sativum L.) leaves against bacterial pathogens isolated from the organs associated with digestive system of rabbit. This study also evaluated the influence of varied doses of aqueous extract of C.

Pathogenic flora composition and overview of the trends used for bacterial pathogenicity identifications.

Over 250 species of resident flora in the class of bacteria are known to be associated with humans. These conventional flora compositions is often determined by factors which may not be limited to genetics, age, sex, stress and nutrition of humans. Man is constantly in contact with bacteria through media such as air, water, soil and food.