Clinical Implications of High-Sensitivity Troponin Elevation Levels in Non-ST-Segment Elevation Myocardial Infarction Patients: Beyond Diagnostics.

Standard troponin has long been pivotal in diagnosing coronary syndrome, especially Non-ST-Segment Elevation Myocardial Infarction (NSTEMI). The recent introduction of high-sensitivity troponin (hs-cTnI) has elevated it to the gold standard. Yet, its nuanced role in predicting angiographic lesions and clinical outcomes, notably in specific populations like obesity, remains underexplored.

Modeling the variability of insulin sensitivity for people with Type 1 Diabetes based on clinical data from an artificial pancreas study.

Type 1 Diabetes is an autoimmune disease that eliminates endogenous insulin production. Without the crucial hormone insulin, which is necessary to equilibrate the blood glucose level, the patient must inject insulin subcutaneously. Treatment must be personalized (timing and size of insulin delivery) to achieve glycaemic equilibrium and avoid long-term comorbidities.

[Prediction of hospital mortality of ST elevation myocardial infarction using TIMI score].

Background: Thrombolysis in myocardial infarction risk score (TIMI-RS) was designed to predict early mortality in patients with a ST elevation acute myocardial infarction (STEAMI).

Aim: To evaluate the predictive capacity for hospital mortality of TIMI-RS.

Material And Methods: Patients with ≤ 12-hour evolution STEAMI were selected from a prospective registry of all patients hospitalized in our coronary unity within January 1988 and December 2005.

[Giant coronary artery fistula: Report of one case].

Coronary artery fistulae are abnormal connections between a coronary artery and any cardiac chamber or other vessels. Most of them have a congenital origin. We report a 60 years old woman referring a history of progressive dyspnea and orthopnea during the last year.

Model-Based Design and Experimental Validation of Control Modules for Neuromodulation Devices.

Goal: The goal of this paper is to propose a model-based control design framework, adapted to the development of control modules for medical devices. A particular example is presented in which instantaneous heart rate is regulated in real-time, by modulating, in an adaptive manner, the current delivered to the vagus nerve by a neuromodulator.

Methods: The proposed framework couples a control module, based on a classical PI controller, a mathematical model of the medical device, and a physiological model representing the cardiovascular responses to vagus nerve stimulation (VNS).

On-off closed-loop control of vagus nerve stimulation for the adaptation of heart rate.

Vagus nerve stimulation (VNS) is a potential therapeutic approach in a number of clinical applications. Although VNS is commonly delivered in an open-loop approach, it is now recognized that closed-loop approaches may be necessary to optimize the therapy and minimize side effects of neuro-stimulation devices. In this paper, we describe a prototype system for real-time control of the instantaneous heart rate, working synchronously with the heart period.

[Features of acute myocardial infarction among aged patients].

Background: Among aged patients, acute myocardial infarction has more complications and there is a tendency to underuse proven treatments.

Aim: To report the features of acute myocardial infarction among aged patients.

Material And Methods: Analysis of a registry of patients with acute myocardial infarction admitted to a coronary unit.

[Primary angioplasty for acute myocardial infarction with an anomalous origin of right coronary artery: report of one case].

Anomalous origin of coronary arteries is a rare anatomical defect and its association with acute myocardial infarction is unusual. We report a 58-year-old male with ST-Segment elevation. Myocardial infarction of the inferior wall caused by a total occlusion on the proximal third of an anomalous right coronary artery, that was effectively treated with primary angioplasty with stent placement.

[Angioplasty compared to thrombolysis as the initial reperfusion therapy in acute myocardial infarction].

Background: Primary angioplasty is superior to intravenous thrombolysis as reperfusion therapy for acute myocardial infarction.

Aim: To compare the results of available reperfusion strategies for initial management of acute myocardial infarction during hospitalization and 5 years follow up.

Patients And Methods: Historical cohort study from a prospective registry of patients admitted with acute myocardial infarction to our center.

[Sub capsular splenic hematoma in a sickle cell trait carrier. Case report].

Drepanocytic anemia is an uncommon hereditary disease in Chile. The heterozygous state of drepanocytic anemia or "sickle trait" has a frequency of 8% among Afro-Americans. A small number of patients carrying hemoglobin S are homozygous, with clinical manifestations of hemolytic anemia and thrombotic disease.

[Coronary artery origin anomalies. Analysis of 10.000 coronary angiographies].

Background: Between 0.3 and 1.3% of coronary arteries, have anomalous origins.

[Clinical features and prognosis of acute myocardial infarction among patients aged 80 years or older].

Background: Subjects older than 80 years have more complicated acute myocardial infarctions and are subjected to less reperfusion procedures.

Aim: To describe the hospital evolution and follow up of patients older than 80 years, suffering an acute myocardial infarction.

Material And Methods: Patients older than 80 years, were selected from a prospective registry of acute myocardial infarction.

[Coronary angiography: indications, results and complications in 5.000 consecutive patients].

Background: There are guidelines about equipment, premises, personnel, indications and complications rates for coronary angiography, that every center performing this procedure should adhere.

Aim: To report the experience with 5.000 coronary angiographies and to assess the compliance of the center with the current guidelines.

[Acute and long-term clinical results of bare metal coronary stenting].

Background: Since the introduction of stents in 1994, improved clinical results have boosted the development of coronary angioplasty in Chile. Drug eluting stents, that have a reduced rate of restenosis, are being increasingly used.

Aim: To assess the acute and long-term results of bare metal stent implantation.

[Comparative study of coronary angioplasty in diabetic patients. Immediate clinical and angiographic results and clinical evolution in the first year of follow up].

Background: The success of revascularization procedures for coronary artery disease could be lower in diabetic patients.

Aim: To report the results of coronary angioplasty in diabetic and non diabetic patients.

Patients And Methods: All angioplasty procedures performed between 1996 and 1999 were recorded.

[Acute myocardial infarction caused by total occlusion of the left main coronary artery treated with percutaneous endoluminal revascularization. Clinical case].

We report a 43 years old female who developed an intense precordial pain and arterial hypotension. The patient was admitted to the emergency room in cardiogenic shock. An emergency angiography revealed a total occlusion of the left main coronary artery.

[The classification of coronary lesion from Society for Cardiac Angiography and Intervention predicts better results of coronary angioplasty than the one from American College of Cardiology/American Heart Association Coronary Disease].

Background: The classification of coronary lesion complexity, using the American College of Cardiology/American Heart Association (ACC/AHA) is a predictor of balloon angioplasty success. Stents have improved results even in complex lesions.

Aim: To compare the ACC/AHA and the new Society for Cardiac Angiography (SCA&I) coronary lesion scores as predictors of angioplasty success.

[Secondary ionizing radiation generated by digital and analog coronary cineangiographic equipment: influence of external systems of radiologic protection].

Background: Exposure to ionizing radiation is a known hazard of radiological procedures.

Aim: To compare the emission of secondary ionizing radiation from two coronary angiographic equipment, one with digital and the other with analog image generation. To evaluate the effectiveness of external radiological protection devices.

[Cisapride does not modify prolonged Q-T interval in patients with liver cirrhosis].

Background: Abnormal small bowel motility, observed in liver cirrhosis, can be reversed with cisapride. Since both cisapride and liver disease are associated with prolonged QT interval, the possibility of adverse cardiovascular effects might be expected with cisapride treatment in these patients.

Aim: To evaluate QT interval and other electrocardiographic changes during long term treatment with cisapride in cirrhotic patients.

[Angioplasty in acute myocardial infarction. Early and late results].

Background: The usefulness of angioplasty in the first hours of an acute myocardial infarction is widely demonstrated. However, its long term effects are less well known.

Aim: To report the effects of coronary angioplasty on early and late outcome of patients with acute myocardial infarction.

[Endovascular stent implantation in the treatment of coronary artery disease: angiographic, and immediate and late clinical results].

Background: Coronary revascularization allows a better survival and quality of life in high risk patients with coronary artery disease.

Aim: To report the experience in stent placement as treatment for obstructive atherosclerotic coronary artery disease.

Patients And Methods: A prospective analysis of 105 stent placements.

[Mechanical reperfusion in acute myocardial infarction after failure of thrombolysis with intravenous streptokinase].

Aim: to report the clinical evolution of four patients with acute myocardial infarction that were subjected to immediate coronary angioplasty due to the failure of reperfusion with streptokinase.

Background: the limitations for the use of thrombolytic agents, an accepted treatment of acute myocardial infarction, or their uncertain results in selected groups of patients has prompted the search for mechanical revascularization infarction subjected to thrombolytic therapy with streptokinase (1.500.