Publications by authors named "Ufuk Ersoy"
Sarcopenia is characterised by the loss of skeletal muscle mass and function, which leads to a high risk of increased morbidity and mortality. Maternal malnutrition has been linked to impaired development of skeletal muscle of the offspring; however, there are limited studies that report the long-term effect of a maternal low-protein diet during lactation on the ageing of skeletal muscles. This study aimed to examine how a maternal low-protein diet (LPD) during lactation affects skeletal muscle ageing in the offspring.
View Article and Find Full Text PDFArticle Synopsis
- Protein deficiency is a global issue that negatively affects offspring development and may lead to age-related diseases like sarcopenia through changes in the epigenome and organ structure.
- Research shows that while a normal protein diet post-lactation does not significantly impact the neuromuscular system later in life, a lifelong low-protein diet results in serious nerve and muscle changes.
- These changes include muscle atrophy, increased proteasome activity, and a denervation phenotype, suggesting that long-term protein restriction can exacerbate conditions like sarcopenia by affecting both peripheral nerves and neuromuscular junctions.
The MC3T3-E1 preosteoblastic cell line is widely utilised as a reliable in vitro system to assess bone formation. However, the experimental growth conditions for these cells hugely diverge, and, particularly, the osteogenic medium (OSM)'s composition varies in research studies. Therefore, we aimed to define the ideal culture conditions for MC3T3-E1 subclone 4 cells with regard to their mineralization capacity and explore if oxidative stress or the cellular metabolism processes are implicated.
View Article and Find Full Text PDFThe early life environment significantly affects the development of age-related skeletal muscle disorders. However, the long-term effects of lactational protein restriction on skeletal muscle are still poorly defined. Our study revealed that male mice nursed by dams fed a low-protein diet during lactation exhibited skeletal muscle growth restriction.
View Article and Find Full Text PDFContext: Mobilization has been used for enhancing muscle strength.
Objective: The aim of this study was to investigate the acute effect of talocrural joint mobilization on ankle dorsiflexor muscle strength in healthy individuals, which has not yet been studied.
Design: Randomized controlled single-blind study.