Publications by authors named "Uehara K"
Background: Two-stage revision is known as the gold-standard method for knee prosthetic joint infection (PJI), but the most suitable treatment method remains controversial. Typically, weight-bearing is restricted during the interval between the stages. The aim of this study was to evaluate the clinical outcomes of unrestricted weight bearing with cement spacers fabricated using the Knee Articulating Spacer Mold (KASM®; Ortho Development Corporation, Draper, UT, USA) for knee PJI.
View Article and Find Full Text PDFBackground: Pembrolizumab, an immune checkpoint inhibitor (ICI), shows significant survival benefits in patients with microsatellite instability-high (MSI-H) metastatic colorectal cancer (mCRC), but its efficacy in microsatellite-stable (MSS) mCRC is limited. Although ICIs are effective in tumor mutational burden-high (TMB-H) solid tumors, the impact on MSS-TMB-H mCRC, a rare subset within MSS mCRC, remains unclear.
Materials And Methods: We conducted a retrospective analysis using clinical and genomic data from the Center for Cancer Genomics and Advanced Therapeutics (C-CAT) repository in Japan.
β-Lactams are the most widely used antibiotics for the treatment of bacterial infections because of their proven track record of safety and efficacy. However, susceptibility to β-lactam antibiotics is continually eroded by resistance mechanisms. Emerging multidrug-resistant (MDR) strains possessing altered alleles (encoding PBP2) pose a global health emergency as they threaten the utility of ceftriaxone, the last remaining outpatient antibiotic.
View Article and Find Full Text PDFIntroduction: Local recurrence for upper tract urothelial carcinoma typically occurs within 2 years post-surgery. We report a rare case of retroperitoneal recurrence as squamous cell carcinoma 10 years after nephroureterectomy.
Case Presentation: A 67-year-old female was referred to our urology department for a left ureteral tumor.
Self-incompatibility (SI) is a genetic mechanism to prevent self-fertilization and thereby promote outcrossing in hermaphroditic plant species through discrimination of self and nonself-pollen by pistils. In many SI systems, recognition between pollen and pistils is controlled by a single multiallelic locus (called the S-locus), in which multiple alleles (called S-alleles) are segregating. Because of the extreme level of polymorphism of the S-locus, identification of S-alleles has been a major issue in many SI studies for decades.
View Article and Find Full Text PDFMixed epithelial and stromal tumor of the kidney (MESTK) is a rare renal tumor characterized by both cystic and solid components. Although typically benign, its components can undergo malignant transformation, manifesting as a sarcomatous feature. Carcinomatous transformations are exceedingly rare.
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- This study focuses on retrograde denervation in severe entrapment neuropathy, specifically examining motor nerve conduction velocity (MNCV) in patients with cubital tunnel syndrome (CuTS).
- Researchers reviewed the preoperative severity of 95 elbows and assessed the postoperative outcomes of 67 elbows after surgery, categorizing results into favorable and unfavorable groups.
- Findings indicate that lower upper arm MNCV is linked to poorer surgical outcomes, suggesting that MNCV measurements could be essential in predicting postoperative success, particularly in severe cases.
Article Synopsis
- Floodplains are rich ecosystems affected by climate change and human actions, leading to many endangered species, like the Itasenpara bitterling fish in Japan, which needed population history studies for conservation efforts.
- Researchers used genetic sequences to analyze the bitterling's population structure and found surprising patterns of gene flow and differentiation occurring long after the geological changes expected to drive those patterns.
- The study indicates that these fish adapted by dispersing across mountains and were heavily impacted by both climate cycles and human activities, emphasizing the need for thoughtful conservation strategies based on these findings.
Background: Data on the impact of valve position on clinical outcomes in patients with atrial fibrillation (AF) and bioprosthetic valves (BPVs) are limited.
Methods And Results: The BPV-AF Registry was a multicenter, prospective, observational study involving 894 patients with BPVs and AF. In this post-hoc substudy, patients were classified according to BPV position: aortic (n=588; 65.
Objective: To investigate the incidence of male sexual dysfunction (SD) including erectile dysfunction (ErD) and ejaculatory dysfunction (EjD) after minimally invasive rectal cancer surgery.
Background: Male SD significantly affects post-rectal cancer surgery quality of life (QOL). Current assessments using the International Index of Erectile Function-5 are unsuitable for patients with reduced postoperative sexual activity, because it assumes sexual intercourse.
Article Synopsis
- Researchers studied immune cells in patients with esophageal squamous cell cancer undergoing immune checkpoint blockade (ICB) therapy to understand what makes the treatment effective.
- They found a specific group of CD39PD-1CD8 T cells, particularly the TCF1 subset known as precursor exhausted T (CD39 Tpex) cells, which were linked to better treatment outcomes.
- These CD39 Tpex cells are mostly found in the tumor's supportive tissue and are recruited from tertiary lymphoid structures (TLS), indicating a significant role in the immune response against tumors during ICB therapy.
Article Synopsis
- - The study analyzed records of 47 patients with primary cardiac tumors from Kyushu University Hospital, finding that 13 (28%) were diagnosed with malignant tumors, including various sarcomas and lymphomas, highlighting the rarity of such cases.
- - Cardiovascular complications were prevalent, with 77% of patients experiencing issues like heart dysfunction, arrhythmias, and right heart failure, often linked to the aggressive multimodal treatment involving surgery, chemotherapy, and radiotherapy.
- - Two cases exemplified severe complications: one patient faced significant heart failure post-treatment, while another developed a heart block due to tumor placement, indicating the need for careful management to improve patient outcomes.
Article Synopsis
- Deltoid muscle detachment and atrophy can happen after shoulder surgeries, particularly after arthroscopic rotator cuff repair (ARCR).
- A study involving 72 patients analyzed changes in deltoid muscle structure and function over two years using MRI and muscle strength tests.
- Results showed a significant decrease in both the affected and unaffected deltoid muscle volumes at 1 month post-surgery, but both sides returned to preoperative levels by 12 months, with notable reductions in muscle thickness also observed.
This research aimed to examine the effect of daily intake of food containing strain T21 (T21) on skin conditions and inflammation-related markers in healthy adults who experience itching because of dry skin and have an atopic predisposition. A randomized, double-blind, placebo-controlled parallel-group study was conducted on 44 subjects aged 20 to 64 years. Subjects were randomly assigned to receive a T21-containing food or placebo daily for 8 weeks.
View Article and Find Full Text PDFThis investigation defines the roles of various amino acids, neighboring key conserved amino acids in loops C and D of the nicotinic acetylcholine (ACh) receptor (nAChR), in the selective molecular recognition of nicotinic ligands with diverse pharmacophores using ACh binding protein Y55W (-AChBP) mutants (+Q57R; + Q57R+S189 V; + Q57R+S189E; + Q57T; + Q57T+S189 V; + Q57T+S189E) and AChBP (AChBP) mutants (Q55T; Q55T+S186E; Q55R) as insect and mammalian nAChR structural surrogates, respectively. -nitro/cyanoimine insecticides show high affinity to four -AChBPs containing Arg57 or Thr57 and Ser189 or Val189, except for those with Glu189. Pyrazinoyl compound selectively interacts with the three -AChBPs containing Arg57 and Ser189, Val189, or Glu189.
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- A systematic review and meta-analysis was conducted to compare the safety and effectiveness of laparoscopic versus open surgery after SEMS placement in patients with obstructive colorectal cancer.
- The analysis included data from 15 studies with 883 patients and showed that laparoscopic surgery had a significantly lower postoperative complication rate compared to open surgery.
- However, there were no significant differences in long-term outcomes, such as 3-year recurrence-free survival and overall survival rates, between the two surgical approaches.
Skillful sequential action requires the delicate balance of sensorimotor control, encompassing both robustness and adaptability. However, it remains unknown whether both motor and neural responses triggered by sensory perturbation undergo plastic adaptation as a consequence of extensive sensorimotor experience. We assessed the effects of transiently delayed tone production on the subsequent motor actions and event-related potentials (ERPs) during piano performance by comparing pianists and non-musicians.
View Article and Find Full Text PDFPreexisting cardiovascular disease (CVD) is a pivotal risk factor for severe coronavirus disease 2019 (COVID-19). We investigated the longitudinal (over 1 year and 9 months) humoral and cellular responses to primary series and booster doses of mRNA COVID-19 vaccines in patients with CVD. Twenty-six patients with CVD who received monovalent mRNA COVID-19 vaccines were enrolled in this study.
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- The study investigates risk factors for lateral lymph node metastasis in rectal cancer and aims to improve diagnostic accuracy using machine learning models.
- It analyzed data from patients who underwent lymph node dissection without prior treatment across 15 Japanese hospitals from 2017 to 2019, focusing on preoperative factors and MRI findings.
- Results identified key risk factors and developed machine learning models, showing that poorly differentiated adenocarcinoma and certain tumor characteristics significantly increase the likelihood of metastasis.
Background: The significance of resection of para-aortic lymph node metastasis in colorectal cancer is controversial.
Objective: To clarify the prognosis of colorectal cancer after para-aortic lymph node metastasis resection.
Design: Multicenter retrospective study.
Article Synopsis
- * A total of 189 patients who underwent total mesorectal excision and LLND were included, and data on local recurrence (LR) and lateral lymph node recurrence (LLNR) were analyzed after matching similar patient characteristics.
- * While 39 patients had pathological LLNM, the analysis showed similar rates of LR and LLNR in both groups after balancing their characteristics, suggesting LLND can provide comparable local control regardless of LLNM presence.
Background/aim: A deep ultraviolet (DUV) light-emitting diode (LED) is a device that can irradiate electromagnetic waves from 250 nm to 350 nm. Tousled-like kinase 1 (TLK1) encodes a nuclear serine/threonine kinase, which is thought to influence the effects of DUV irradiation in cancer. The aim of this study was to clarify the interaction of TLK1 with DUV irradiation-induced DNA damage in cancer cells.
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- The study aimed to validate the ABC score, a tool for predicting neurological outcomes in cardiac arrest cases that did not experience prehospital return of spontaneous circulation (ROSC).
- Researchers analyzed data from the All-Japan Utstein Registry across different time periods (2007-2009, 2012-2014, and 2017-2019) and used cerebral performance categories (CPCs) to assess outcomes one month post-arrest.
- Results showed that higher ABC scores were associated with better neurological outcomes, with the ABC score demonstrating good predictive accuracy across all guideline periods.