L. Seed Oil Modulates Dyslipidemia and Neuronal Dysfunction in Tramadol-Induced Toxicity in Wistar Albino Rats.

The modulating effects of seed oil (CPSO) on dyslipidemia and neuronal dysfunction in tramadol toxicity were studied. Fifty-six albino rats were divided into seven groups of eight rats each after a 2-week acclimatization period. All animals had unrestricted access to water and feed, and treatments were administered orally once daily for 42 days.

Protective effect of lyophilized extract against carboplatin-induced liver injury via inhibition of oxidative stress and inflammation in rats.

Patients who are receiving carboplatin therapy for cancer often experience toxic side effects. This study examined the effects of lyophilized aqueous leaf extracts of F. capensis (LALEFC) on oxidative stress and inflammatory markers in albino rats with carboplatin-damaged livers.

Utilizing Indigenous Flora in East Africa for Breast Cancer Treatment: An Overview.

Background: Breast cancer is a significant global health challenge, contributing substantially to cancer- related deaths. Conventional treatment methods, including hormone therapy, chemotherapy, surgical interventions, and radiation, have long been utilized. However, these traditional treatments are often associated with serious side effects and drug resistance, limiting their efficacy.

Ameliorative Potential of Pumpkin Seed Oil ( L.) Against Tramadol-Induced Oxidative Stress.

Background Of The Study: The increase in the therapeutic use of tramadol in the management of moderate to severe pains in some disease conditions and its unregulated access has led to its associated toxicity and there is little or no information on the protection against its associated toxicity.

Aim Of The Study: Considering the medicinal value of pumpkin seed oil, its availability, and neglected use, it becomes necessary to evaluate the possible potential of the seed oil in tramadol-induced oxidative stress in Wister Albino rats.

Methods Of The Study: This study used fifty-six (56) albino rats to determine the impact of seed oil (CPSO) on tramadol-induced oxidative stress.

Studies on Ethanol Extracts of Against Carbon Tetrachloride-Induced Hepatotoxicity in Rats.

<b>Background and Objective:</b> Liver disease orchestrated by noxious chemicals are serious health problems the world over. Traditionally, there are claims that ethanol extracts of leaves and stem barks of <i>Olax subscorpioidea</i> are used in the treatment of hepatic disorders. Thus, it investigated the impacts of ethanol extract of leaves and stem bark of <i>Olax subscorpioidea</i> against carbon tetrachloride (CCl₄)-induced liver damage in rats.

Effect of ethanol and aqueous extracts of seed pod of Copaifera salikounda (Heckel) on complete Freund's adjuvant-induced rheumatoid arthritis in rats.

The antirheumatoid arthritis potential of ethanol and aqueous extracts of seed pod of Copaifera salikounda (SPCS) was evaluated using the chicken collagen/complete Freund's adjuvant-induced arthritic rats model. Adjuvat-induced rats were treated with varied doses of the extracts (400, 600, and 800 mg/kg body weight) and with reference drug, indomethacin for 21 days. Antiarthritic evaluation was done through measurement of body weight, paw size, inflammatory makers, hematological parameters, cytokines, antioxidant enzymes, reduced glutathione, lipid peroxidation as well as histopathological examinations.

Blood Pb Levels in pregnant Nigerian women in Abakaliki, South-Eastern Nigeria.

Environmental lead (Pb) exposure and toxicity have been recognised as public health problems of global importance, affecting both the developed and developing nations. In this work, blood Pb of pregnant women that were not exposed to lead by their occupation (n = 349), with mean ± SD age of 27.0 ± 4.

Maternal sociodemographic parameters: impact on trace element status and pregnancy outcomes in Nigerian women.

To determine the impact of socioeconomic status on plasma trace element status and pregnancy outcomes, 349 pregnant women, aged 15-40 years (mean 27.04 +/- 2.75 years), recruited at < or = 25 weeks (mean 21.