Publications by authors named "Udi O Andrew"

Mitochondria play a pivotal role in cellular metabolism, energy production, and apoptotic signaling, making mitophagy, the selective degradation of damaged mitochondria, crucial for mitochondrial health. Dysregulation of mitophagy has been implicated in various neuroendocrinopathies, yet the mechanisms linking these processes remain poorly understood. This review aims to explore the intersection between mitophagy and neuroendocrinopathy, addressing the critical gaps in knowledge regarding how mitochondrial dysfunction may contribute to the pathophysiology of neuroendocrine disorders.

View Article and Find Full Text PDF

Traumatic brain injury (TBI) is a major global disability and mortality cause, with the gut-brain axis playing a crucial role in its pathophysiology. Neuroinflammation, triggered by microglia and astrocytes, contributes to neuronal damage and cognitive impairment. This paper aims to explore the relationship between the gut-brain axis and neuroinflammation in TBI and its potential implications for therapeutic interventions.

View Article and Find Full Text PDF
Article Synopsis
  • Traumatic brain injury (TBI) is a major cause of disability globally, with complex primary and secondary injury processes involved.
  • Microglia, the central nervous system's immune cells, play a critical role in TBI-related inflammation, acting both protectively and harmfully.
  • Understanding the timing and mechanisms of microglial activity is essential for creating effective therapies to manage neuroinflammation and enhance recovery from TBI.
View Article and Find Full Text PDF

The study investigated the effects of quercetin and putative mechanisms involved against endosulfan-testicular impairments in rats. Rats were allotted into five treatment groups (n = 5). Groups 1-2 had normal saline and maize oil (vehicle) (10 mL/kg), group 3 received quercetin (20 mg/kg), 4-5 had endosulfan (5 mg/kg, p.

View Article and Find Full Text PDF

Lead exposure is a well-known environmental hazard. Its accumulation in humans may pose a danger to health. The present study investigated the beneficial effect of extract (OG) in reducing lead acetate (LA) induced oxidative damage in the spleen, thymus, and hematological indices.

View Article and Find Full Text PDF