Rapid keratitis and perforation after corneal collagen cross-linking.

Purpose: To describe a case of rapid keratitis and corneal perforation after epithelium off collagen cross-linking.

Observations: We report a case of a 17-year-old male who underwent collagen cross-linking with the protocol and device approved by the United States Food and Drug Administration (FDA) that developed a corneal infiltrate 3 days after the procedure. He later developed corneal thinning and perforation on day 5 requiring the use of cyanoacrylate glue and a Kontur lens.

Treatment Limitations With PROSE (Prosthetic Replacement of the Ocular Surface Ecosystem): One Centers Experience.

Objectives: The prosthetic replacement of the ocular surface ecosystem (PROSE) device is used to treat difficult-to-manage ocular surface disease (OSD) and ectasia. Previous studies have demonstrated positive treatment outcomes. This study aims to document treatment failures to better tailor treatment and address limitations with its use.

Spontaneous Descemet Membrane Detachment 20 Years After Penetrating Keratoplasty for Keratoconus.

Purpose: To report 2 cases of spontaneous Descemet membrane (DM) detachment 20 years after penetrating keratoplasty for keratoconus.

Methods: A retrospective chart review of 2 patients was performed.

Results: Two male patients-ages 59 and 50-presented 21 and 25 years, respectively, after uncomplicated penetrating keratoplasty for keratoconus, complaining of foreign body sensation.

Paraproteinemic Keratopathy: The Expanding Diversity of Clinical and Pathologic Manifestations.

Purpose: To describe 7 patients with paraproteinemic keratopathy and to highlight the clinical and pathologic diversity of this rare entity and the importance of timely, systemic evaluation.

Design: Retrospective, multicenter collaborative case series.

Participants: Seven patients with paraproteinemic keratopathy.

The Association of Demodex with Chalazia: A Histopathologic Study of the Eyelid.

Purpose: To investigate the association of Demodex with chalazia and to describe the associated histopathologic changes in the eyelid tissue.

Methods: In a retrospective histopathologic case-control study, 78 ectropion/entropion repair eyelid wedge resections were examined. Serial sections were obtained on formalin-fixed, paraffin-embedded tissues, stained with hematoxylin-eosin and studied by light microscopy.

Recurrence of Ocular Surface Squamous Neoplasia Treated With Excisional Biopsy and Cryotherapy.

Purpose: To evaluate the recurrence rate of ocular surface squamous neoplasias (OSSN) after excision and cryotherapy in an academic cornea practice and to determine factors associated with recurrence.

Design: Retrospective interventional case series.

Methods: All cases of OSSN from 1998 through 2013 that were treated with excisional biopsy and adjunctive cryotherapy were retrospectively reviewed.

Descemet stripping endothelial keratoplasty for the treatment of combined fuchs corneal endothelial dystrophy and keratoconus.

Purpose: To report the first case series of patients with Fuchs corneal endothelial dystrophy (FCD) and keratoconus (KCN) who underwent Descemet stripping endothelial keratoplasty (DSEK).

Methods: This is a retrospective case series of 6 eyes of 4 patients with combined FCD and KCN who underwent DSEK at 3 different centers. Clinical information collected included corneal topography measurements, central corneal thickness, and endothelial cell count.

Immunologic graft rejection in descemet's stripping endothelial keratoplasty and penetrating keratoplasty for endothelial disease.

Objective: To evaluate and compare the cumulative incidence and risk factors for first-episode immunologic graft rejection in Descemet's stripping automated endothelial keratoplasty (DSAEK) and penetrating keratoplasty (PK) and to identify potential risk factors for rejection.

Design: Retrospective chart review.

Participants: All patients who underwent PK or DSAEK for endothelial disease at the Department of Ophthalmology, North Shore LIJ, between January 2004 and June 2010.

Textural interface opacity after descemet stripping automated endothelial keratoplasty: a report of 30 cases and possible etiology.

Purpose: Descemet stripping automated endothelial keratoplasty (DSAEK) has its own set of complications including interface abnormalities. This case series presents the largest number of patients who developed textural interface opacity (TIO) at the graft-host interface after DSAEK.

Methods: This is a retrospective multicenter case series of 30 patients from 7 institutions with the finding of TIO.

Progressive growth in epibulbar complex choristomas: report of 2 cases and review of literature.

Purpose: To report 2 patients with progressive complex choristomas and to review the literature on this subject.

Design: Interventional case reports.

Methods: Clinical and pathologic correlation was performed on 2 patients with progressive epibulbar choristomas.

Full-thickness corneal "vent incisions": how deep does the epithelium penetrate?

Purpose: To evaluate epithelial cell penetration produced by full-thickness "vent incisions."

Methods: Six donor human corneas with intact epithelium were placed on an artificial anterior chamber. Four perforating paracentral vent incisions were made in each cornea using a diamond knife.

Spontaneous reattachment of Descemet stripping automated endothelial keratoplasty lenticles: a case series of 12 patients.

Purpose: To review 12 cases of postoperative detachment and spontaneous reattachment of Descemet stripping automated endothelial keratoplasty (DSAEK) lenticles.

Design: Retrospective, observational case series.

Methods: This was a review of patients undergoing DSAEK at 7 institutions.

Preservative-free low-dose dexamethasone for the treatment of chronic ocular surface disease refractory to standard therapy.

Purpose: To evaluate the short-term safety and efficacy of topical preservative-free dexamethasone 0.01% for the treatment of ocular surface disease and/or tearing refractory to conventional treatments.

Methods: Retrospective chart review of all patients who received topical unpreserved dexamethasone 0.

Safety of overnight orthokeratology for myopia: a report by the American Academy of Ophthalmology.

Objective: To review the published literature to evaluate the safety of overnight orthokeratology (OOK) for the treatment of myopia.

Methods: Repeated searches of peer-reviewed literature were conducted in PubMed (limited to the English language) and the Cochrane Central Register of Controlled Trials (no language limitations) for 2005, 2006, and 2007. The searches yielded 495 citations.

Visual outcome and bacterial sensitivity after methicillin-resistant Staphylococcus aureus-associated acute endophthalmitis.

Purpose: To determine the frequency, visual outcome, and bacterial sensitivity in cases of methicillin-resistant Staphylococcus aureus (MRSA)-associated acute postoperative endophthalmitis occurring after cataract surgery.

Design: Retrospective, consecutive, observational case series.

Methods: Sixty-four cases of acute endophthalmitis occurring within six weeks after cataract surgery were identified over a three-year interval at a single vitreoretinal practice.

Clinical response of contact lens-associated fungal keratitis to topical fluoroquinolone therapy.

Purpose: To report 5 cases of fungal keratitis associated with contact lens wear that resolved or significantly improved without antifungal therapy.

Methods: Observational case report of 5 patients with a history of contact lens wear who presented with infectious keratitis. Two patients had growth of fungal species on corneal microbiologic cultures, and of the remaining 3 patients, 2 showed fungal elements on confocal microscopy.

A pooled analysis of posttransplant survival following combined heart-liver transplantation.

Because no single center has accumulated a large experience with this complex operation, the effectiveness of combined orthotopic heart transplantation (OHT) and orthotopic liver transplantation (OLT) in achieving long-term survival has been unknown. Cases of OHT-OLT were pooled from a U.S.

In vitro activity of fluoroquinolones, vancomycin, and gentamicin against methicillin-resistant Staphylococcus aureus ocular isolates.

Purpose: To determine the antibacterial activity of fluoroquinolones, vancomycin, and gentamicin against methicillin-resistant Staphylococcus aureus (MRSA) ocular surface isolates.

Design: Retrospective review.

Methods: MRSA isolates were obtained from 21 patients.

Acute endophthalmitis in eyes treated prophylactically with gatifloxacin and moxifloxacin.

Purpose: To study the use of prophylactic fourth-generation fluoroquinolone antibiotics, gatifloxacin and moxifloxacin, and bacterial sensitivity in cases of acute postoperative endophthalmitis following cataract surgery.

Design: Retrospective, consecutive, observational case series.

Methods: Forty-two eyes of 42 patients with acute endophthalmitis occurring within six weeks after cataract surgery were identified.

Hepatitis C viral recurrence in a pediatric patient following liver transplantation.

Hepatitis C virus (HCV) infections are known to have a more benign course in children than in adults. Although the natural history of HCV recurrence after liver transplantation has been well studied in adult patients, much less is known about HCV recurrence after liver transplantation in pediatric patients. Herein, we report a case of a pediatric patient with HCV presumably acquired through vertical transmission.

The natural history of hepatitis C virus in pediatric liver transplant recipients.

Although rare in the pediatric population, the natural history of hepatitis C virus (HCV) recurrence in pediatric patients undergoing orthotopic liver transplantation (OLT) for end-stage liver disease secondary to HCV has not been well described. We performed an analysis of all 67 pediatric patients (< 17 years old) who have undergone OLT for HCV in the United States between 1/1988 and 6/2005. The 67 pediatric patients received a total of 83 OLTs for HCV.