Malaria and Dengue Co-infection: A Comprehensive Study in Peshawar, Pakistan.

Background: Malaria and dengue are significant mosquito-borne diseases prevalent in tropical and subtropical climates, with increasing reports of co-infections. This study aimed to determine the frequency, patterns, and risk factors of these co-infections in Peshawar.

Methods: A cross-sectional study was conducted from June to December 2023 in three tertiary care hospitals in Peshawar.

Viscosol Treatment Ameliorates Insulin-Mediated Regulation of Dyslipidemia, Hepatic Steatosis, and Lipid Metabolism by Targeting PTP1B in Type-2 Diabetic Mice Model.

Type 2 diabetes mellitus (T2DM), a metabolic disorder, has the hallmarks of persistent hyperglycemia, insulin resistance, and dyslipidemia. Protein-tyrosine phosphatase 1B (PTP1B) was found to be overexpressed in many tissues in the case of T2DM and involved in the negative regulation of insulin signaling. So, PTP1B inhibition can act as a therapeutic target for T2DM.

Inflammatory myofibroblastic tumor: A rare cause of intestinal obstruction: Case report.

Introduction And Importance: Inflammatory myofibroblastic tumor IMT is a rare neoplasm with diverse clinical presentations, needing histological confirmation for diagnosis. The tumor often mimics malignant conditions, making accurate diagnosis challenging.

Case Presentation: We report a case of a 29-year-old male presenting with long standing recurrent abdominal pain, with more recent increasing frequency and associated weight loss.

Streptomyces sp. from desert soil as a biofactory for antioxidants with radical scavenging and iron chelating potential.

Iron homeostasis is vital for normal physiology, but in the majority of circumstances, like iron overload, this equilibrium is upset leading to free iron in the plasma. This condition with excess iron is known as hemochromatosis, which has been linked to many side effects, including cancer and liver cirrhosis. The current research aimed to investigate active molecules from Streptomyces sp.

Syringic acid improves cyclophosphamide-induced immunosuppression in a mouse model.

Syringic acid (SA), a naturally occurring phenolic substance present in many edible plants and fruits, has been shown to have potential in immunoenhancement applications. In this study, we investigated the immunomodulatory effects of SA in mitigating cyclophosphamide (CYP)-induced immunosuppression in BALB/c mice using doxycycline as a positive control. SA administration prevented immune organ atrophy and morphological changes in the thymus, spleen, and bone marrow induced by CYP treatment in mice while also showing a dose-dependent enhancement of thymus and spleen indices compared to mice treated with CYP alone.

Efficient Semitransparent Solar Cells Enabled by Introducing -Ethylbenzylamine Additives into Thin Layer of Halide Perovskites.

Semitransparent perovskite solar cells (ST-PSCs) have opened up new applications in tandem devices and building-integrated photovoltaics. Decreasing the thickness of the perovskite film makes it feasible to fabricate semitransparent perovskite layers. However, the formation of high-quality thin perovskite films has been a challenge during the film manufacturing process since the crystallization dynamics of thinner (<200 nm) films are different from that of thick films.

Unraveling retraction dynamics in COVID-19 research: Patterns, reasons, and implications.

Amid the COVID-19 pandemic, while the world sought solutions, few scholars exploited the situation for personal gains through deceptive studies and manipulated data. This paper presents the extent of 400 retracted COVID-19 papers listed by the RetractionWatch database until the month of February 2024. The primary purpose of the research was to analyze journal quality and retractions trends.

Particle Swarm Optimization for exploring Darcy-Forchheimer flow of Casson fluid between co-axial rotating disks with the Cattaneo-Christov model.

In this paper, we carried out a numerical analysis of the fluid dynamics and heat transfer occurring between two parallel disks. The study accounts for the impact of temperature-dependent fluid viscosity and thermal conductivity. We systematically investigated various parameters, including viscosity, thermal conductivity, rotational behavior (rotation or counter-rotation), and the presence of stretching, aiming to comprehend their effects on fluid velocity, temperature profiles, and pressure distributions.

Functional Outcome Of Bristow-Latarjet Procedure In Post-Traumatic Recurrent Anterior Shoulder Instability.

Background: Due to its lack of bony support, the shoulder joint has the broadest range of motion out of all the joints in the body. Instead, one of the joints that dislocate most frequently is the shoulder joint. Multiple pathologic abnormalities, including the traumatic separation of the anterior-inferior capsule-labral complex from the glenoid rim, are caused by repeated anterior glenohumeral dislocation.

Microscopic Colitis in a Young Male: Unveiling the Rarity.

In recent decades, microscopic colitis (MC) has become increasingly recognized as a common contributor to diarrhea and lower gastrointestinal symptoms, particularly among the older demographic. The condition is distinguished by persistent diarrhea with loose watery stools, and endoscopic examination is typically normal with characteristic histopathologic findings. MC is rarely seen under 30 years of age and is less common in males.

Integrated metasurface for efficient polarization conversion and high-gain, low-RCS EM radiation.

This paper presents an innovative design that combines the functionalities of a polarization convertor and an electromagnetic (EM) radiator into a single integrated metasurface. The metasurface consists of two identical metallic split-rings, a circular-shaped patch structure, a dielectric layer, and a reflective metallic ground. The polarization convertor component efficiently converts waves polarized in the x- or y-direction into cross-polarized waves within a frequency range of 8-13 GHz.

Antimalarial drug efficacy and resistance in malaria-endemic countries in HANMAT-PIAM_net countries of the Eastern Mediterranean Region 2016-2020: Clinical and genetic studies.

Introduction: The World Health Organization recommends regular monitoring of the efficacy of nationally recommended antimalarial drugs. We present the results of studies on the efficacy of recommended antimalarials and molecular markers of artemisinin and partner resistance in Afghanistan, Pakistan, Somalia, Sudan and Yemen.

Methods: Single-arm prospective studies were conducted to evaluate the efficacy of artesunate-sulfadoxine-pyrimethamine (ASSP) in Afghanistan and Pakistan, artemether-lumefantrine (AL) in all countries, or dihydroartemisinin-piperaquine (DP) in Sudan for the treatment of Plasmodium falciparum.

The Transition From Localized to Metastatic: A Case Report of Adult TFE3-Positive Xp11.2 Translocation Renal Cell Carcinoma.

Xp11.2 translocation renal cell carcinoma (Xp11.2 RCC) is a rare tumor, occurring more frequently in childhood than in adulthood.

Placental inflammation and pregnancy outcomes: A prospective, observational study in South Asia: The PURPOSe study.

Objective: To examine inflammatory lesions in placentas of stillbirths, preterm neonatal deaths and term controls in India and Pakistan.

Design: Prospective, observational study.

Setting: Three hospitals in India and a large maternity hospital in Pakistan.

Morphological study of the placenta in deliveries with pre-eclampsia: Results from a prospective, observational study in India and Pakistan (PURPOSe).

Objective: To compare placental findings in women with and without pre-eclampsia.

Design: The PURPOSe study included women with stillbirths, women with preterm births and women at term as controls. The placenta of each case was evaluated using the Amsterdam criteria.

Data usefulness in determining cause of stillbirth in South Asia.

Objective: To evaluate the usefulness of data to determine cause of stillbirth in India and Pakistan.

Design: Prospective, observational study.

Settings: Study hospitals in India and Pakistan.

Isolation of multiple electrocardiogram artifacts using independent vector analysis.

Electrocardiogram (ECG) signals are normally contaminated by various physiological and nonphysiological artifacts. Among these artifacts baseline wandering, electrode movement and muscle artifacts are particularly difficult to remove. Independent component analysis (ICA) is a well-known technique of blind source separation (BSS) and is extensively used in literature for ECG artifact elimination.

Comparison of Structural Diagnosis and Management (SDM) approach and MyoFascial Release (MFR) for improving plantar heel pain, ankle range of motion and disability: A randomized clinical trial.

[Purpose] The purpose of this study was to compare the effectiveness of the Structural Diagnosis and Management (SDM) approach with Myofascial Release (MFR) in improving plantar heel pain, ankle range of motion, and disability. [Subjects] Sixty-four subjects, aged 30-60 years, with a diagnosis of plantar heel pain, plantar fasciitis, or calcaneal spur by a physician according to ICD-10, were equally allocated to the MFR ( = 32) and SDM ( = 32) groups by hospital randomization and concealed allocation. [Methods] In this assessor-blinded randomized clinical trial, the control group performed MFR to the plantar surface of the foot, triceps surae, and deep posterior compartment calf muscles, while the experimental group performed a multimodal approach utilizing the SDM concept for 12 sessions over 4 weeks.

Blue Rubber Bleb Nevus Syndrome Presenting as Anemia, Hemorrhage, and Hemangiomas: A Rare Case Report.

Background: Blue Rubber Bleb Nevus syndrome (BRBNS) is a rare disorder, that results in congenital cutaneous hemangiomas of the skin and gastrointestinal tract. Although asymptomatic, the nevi present as soft, non-mobile, dark blue, compressible papules. Clinically it presents as iron deficiency anemia due to occult gastrointestinal bleeding.

Targeted Inhibition of Protein Tyrosine Phosphatase 1B by Viscosol Ameliorates Type 2 Diabetes Pathophysiology and Histology in Diabetic Mouse Model.

Type 2 diabetes mellitus (T2DM) is one of the most common forms of diabetes. We are living in the middle of a global diabetes epidemic. Emerging pieces of evidence are suggesting the increased expression of protein tyrosine phosphatase 1B (PTP1B) in the pancreas and adipose tissues during T2DM.

Wavelets based physics informed neural networks to solve non-linear differential equations.

In this study, the applicability of physics informed neural networks using wavelets as an activation function is discussed to solve non-linear differential equations. One of the prominent equations arising in fluid dynamics namely Blasius viscous flow problem is solved. A linear coupled differential equation, a non-linear coupled differential equation, and partial differential equations are also solved in order to demonstrate the method's versatility.

Locally Aggressive Mixed Epithelial and Stromal Tumour of Kidney Leading to Nephron Loss.

Mixed epithelial and stromal tumour (MEST) is a rare benign renal tumour. It is mainly found in perimenopausal women. We present a case of a 42-year female with no known comorbid who was presented in the outpatient clinic for the right flank pain.

Efficacy of guselkumab, a selective IL-23 inhibitor, in Preventing Arthritis in a Multicentre Psoriasis At-Risk cohort (PAMPA): protocol of a randomised, double-blind, placebo controlled multicentre trial.

Introduction: Psoriatic arthritis (PsA) is a complex, immune-mediated disease associated with skin psoriasis that, if left untreated, can lead to joint destruction. Up to 30% of patients with psoriasis progress to PsA. In most cases, psoriasis precedes synovio-entheseal inflammation by an average of 5-7 years, providing a unique opportunity for early and potentially preventive intervention in a susceptible and identifiable population.