CoDNet: controlled diffusion network for structure-based drug design.

Motivation: Structure-based drug design (SBDD) holds promising potential to design ligands with high-binding affinity and rationalize their interaction with targets. By utilizing geometric knowledge of the three-dimensional (3D) structures of target binding sites, SBDD enhances the efficacy and selectivity of therapeutic agents by optimizing binding interactions at the molecular level. Here, we present CoDNet, a novel approach that combines the conditioning capabilities of ControlNet with the potency of the diffusion model to create generative frameworks for molecular compound design.

Spatiotemporal dynamics of geomorphology, landuse, and storm surge inundation of FDMN settled in Bhasan Char island using geo-spatial techniques.

Bhasan Char has undergone noteworthy transformations in its geographical characteristics since its emergence in 2003. Driven by sediment transported by the Ganges-Brahmaputra-Meghna river system, the island has gradually transitioned from a stretched-out configuration to a more rounded shape primarily due to continuous accretion, while erosion has been minimal since 2012. Currently, the island is being prepared to accommodate over 1 million Forcefully Displaced Myanmar Nationals (FDMN) refugees.

Climate change and women's mental health in two vulnerable communities of Bangladesh: An ethnographic study.

Climate change is one of the most significant challenges humanity faces in the 21st century, with its health impacts being profoundly felt in the most vulnerable countries. However, the mental health impacts of climate change, particularly concerning social inequality and gender dynamics, are less documented in the Global South. This paper focuses on the impact of climate change on women's mental health in two vulnerable communities in Bangladesh.

Sustainable and cleaner production of elastic core-spun yarns for stretch denim with maximal utilization of recycled cotton extracted from pre-consumer fabric waste.

Stretch denim is an exclusive and stylish textile made with elastic core-spun yarns. It has gained substantial traction for offering essential elasticity and resilience to the garments while retaining a snug fit and comfort when worn. Denim is produced from coarser cotton yarns necessitating a significant quantity of cotton fiber.

High performance liquid chromatographic method optimized by Box-Behnken design model to determine caffeine in pharmaceutical preparations and urine samples.

A UV-HPLC method optimized by Box-Behnken design model was developed to determine caffeine in pharmaceutical preparations and urine samples. The chromatographic conditions followed were mobile phase: methanol/water/ citrate buffer (pH 4.6) (40:25:35, v/v/v),AcclaimDionex C18 column (ODS 100A˚, 5 µm; 4.

Understanding the impact of acne vulgaris and associated psychological distress on self-esteem and quality of life via regression modeling with CADI, DLQI, and WHOQoL.

Acne vulgaris (AV) is a psychosomatic disorder and can negatively affect individuals, especially in terms of psychological well-being, self-esteem, and quality of life (QoL). The current study aimed to investigate the association between AV and psychological health, as well as the influence of acne and psychological distress in predicting patients' self-esteem and QoL. This cross-sectional study included 150 patients clinically diagnosed with AV.

Pulmonary disease detection and classification in patient respiratory audio files using long short-term memory neural networks.

Introduction: In order to improve the diagnostic accuracy of respiratory illnesses, our research introduces a novel methodology to precisely diagnose a subset of lung diseases using patient respiratory audio recordings. These lung diseases include Chronic Obstructive Pulmonary Disease (COPD), Upper Respiratory Tract Infections (URTI), Bronchiectasis, Pneumonia, and Bronchiolitis.

Methods: Our proposed methodology trains four deep learning algorithms on an input dataset consisting of 920 patient respiratory audio files.

Nanohybrid nanozyme based colourimetric immunosensor for porcine gelatin.

Enzyme mimicking nanomaterials, nanozymes, have gained considerable interest in the scientific community because of their superior properties compared to natural enzymes, including their high stability at extreme conditions, cheaper availability, and ease of synthesis. Herein, we report novel colloidal gold nanoparticles - graphene nanoplatelets - chitosan (CS) with peroxidase mimicking properties used to carry out highly sensitive and selective immunoassay for porcine gelatin detection. The interaction between anti-gelatin antibody conjugated nanozyme with porcine gelatin proteins produced an ultrasensitive immunoassay response in the form of a colourimetric signal directly proportional to the porcine gelatin protein concentration.

Potentiality of sustainable corn starch-based biocomposites reinforced with cotton filter waste of spinning mill.

The textile sector is among the leading industries globally in terms of releasing pollutants and producing waste. Despite being reusable, many wastes are squandered by disposing to landfills or incineration, creating a serious environmental threat. Because the cost of raw materials makes up a significant portion of the total product cost, manufacturers can obtain significant profits by exploiting waste generated during the manufacturing process.

Low-bagging (growth) stretch denim yarn production by spinning optimization of cotton-wrapped dual-core elastane and T400 multifilament.

Cotton-wrapped elastane core yarns have been widely used in producing stretch denim fabrics due to their comfortable stretching and recovery, but they suffer from undesirable fabric growth under prolonged or repeated stress. To reduce that problem, an additional semi-elastic multifilament has been incorporated with the elastane core, called dual-core yarn. Herein, it was intended to produce well-engineered dual-core yarns possessing high elasticity with low bagging.

MicroRNAs within the Basal-like signature of Quadruple Negative Breast Cancer impact overall survival in African Americans.

We previously found that QNBC tumors are more frequent in African Americans compared to TNBC tumors. To characterize this subtype further, we sought to determine the miRNA-mRNA profile in QNBC patients based on race. Both miRNA and mRNA expression data were analyzed from TCGA and validated using datasets from the METABRIC, TCGA proteomic, and survival analysis by KMPLOT.

Recycled fibers from pre- and post-consumer textile waste as blend constituents in manufacturing 100% cotton yarns in ring spinning: A sustainable and eco-friendly approach.

The usage of recycled fibers has achieved enormous importance in the textile sector due to growing environmental awareness, legal requirements for more sustainability and the cost of raw materials. Recycled cotton fibers derived from mechanical shredding of textile waste possess lower quality values and therefore they are spun through blending with other fibers in rotor spinning system for the production of coarse yarns (10-20 Ne) to make denim, towel and home furnishing. Owing to low fiber migration, rotor yarns require high twist during spinning which makes them stiffer and poorly moisture absorbent.

Unusable cotton spinning mill waste: A viable source of raw material in paper making.

Since the reserves of natural renewable resources are being inexorably diminished, the utilization of the recoverable waste in new area is gaining global attention day by day. Besides, as the cost of raw materials constitutes the majority of a production cost, the usage of undesirable but inevitable processing waste in the manufacturing process provides a considerable advantage to the manufacturers. Herein, it has been attempted to exploit unusable cotton spinning mill waste (filter waste derived from humidification plant) to convert it into paper.

Enhancing the quality of elastane-cotton core yarn by compact spinning.

The quest for highly stretchable fabrics with good aesthetic and functional properties has led researchers to constantly involve in mingling of natural and synthetic fibers. Elastane-cotton core yarns have an increasing demand due to their wear comfort and stretch-to-fit properties; therefore, efforts are still going on to optimize the yarn properties to meet the requirements for diversified applications. With a view to enhancing the appearance and performance characteristics of elastane-cotton core yarns, the present work was undertaken to manufacture them by exploiting the most modern and versatile pneumatic compacting mechanism, namely Suessen's EliTe compact spinning system.

Investigation of the performance of okra fiber in woven fabric.

There has been an increase interest in natural plant fibers over the last decades with the intension to identify the ecologically acceptable alternatives to reduce the dependency on synthetic fibers. Naturally extracted okra fiber ( was used in this study. Since okra is a stiff fiber, yarns with 100% Okra fiber was not possible to produce and tried to blend with polyester The maximal ratio of okra was 20% with polyester to spin yarns in traditional ring spinning system.

Woringer-Kolopp disease (localized pagetoid reticulosis): a systematic review.

Objective: Woringer-Kolopp disease (WKD), also known as localized pagetoid reticulosis, is a rare variant of mycosis fungoides as described by the World Health Organization-European Organization for Research and Treatment of Cancer (WHO-EORTC) classification system for cutaneous lymphomas. Our objective was to conduct a comprehensive review that describes and evaluates patient demographics, clinical presentation, immunohistochemical findings, management, and outcomes of WKD.

Methods: The databases PubMed, Embase, and Cochrane Library were searched for relevant literature.

Mental health of students amidst the COVID-19 pandemic: An empirical study.

Purpose: Considering the severity of the global outbreak of coronavirus (COVID-19) on the whole of humanity, particularly in this case on the physical and mental health of students, this study strives to explore the role of financial worries, employment anxiety and COVID-19 knowledge on depression and mental health among students in Bangladesh.

Design/methodology/approach: In the study, a deductive reasoning approach was employed, together with a self-administered questionnaire survey. Questionnaires were sent to the respondents via different social media and by email by creating a Google form link.

Risk factors for bovine rotavirus infection and genotyping of bovine rotavirus in diarrheic calves in Bangladesh.

Bovine rotavirus (BRV) is considered the leading cause of calf diarrhea worldwide, including Bangladesh. In this study we aimed to identify risk factors for BRV infection and determine the G and P genotypes of BRV strains in diarrheic calves. Fecal samples were collected from 200 diarrheic calves in three districts between January 2014 and October 2015.

Predicting Innovative Work Behaviour in an Interactive Mechanism.

The purpose of this paper is to investigate the impacts of employees' creative self-efficacy (CSE) and creative self-identity (CSI) on their innovative work behaviour (IWB), with the indirect effects of creative process engagement (CPE) and creative climate (CC). Following the deductive reasoning approach, the study was conducted on IT-based firms in Bangladesh. A total of 348 surveys were collected using a multi-item questionnaire.

Generalized Pruritus and Gradual Loss of Vision as the Presenting Complaints of Acute HIV Infection: Management Challenges during COVID-19 Pandemic.

Background: Although the prevalence of HIV is low in Bangladesh, there is a potential for an increased number of cases. This is because of high cross-border mobility (India and Myanmar) of people and increased injection drug abusers amongst youth in the cities and rural areas, HIV can present in many ways, from asymptomatic to advanced disease, including various atypical (generalized itching) and advanced (loss of vision) manifestations. A high degree of suspicion is required to diagnose HIV in a country like Bangladesh.

Malignant Proliferating Trichilemmal Tumor of the Scalp: A Systematic Review.

Objectives: Malignant proliferating trichilemmal tumors of the scalp can exhibit aggressive presentation and recurrences. Our objective was to perform an evidence-based systematic review evaluating clinical presentation, tumor characteristics, and treatment modalities used to determine which treatment strategies had the best outcomes.

Methods: The databases PubMed, Embase, and Cochrane Library were searched for relevant literature by the authors.

Mental Health Issues in the COVID-19 Pandemic and Responses in Bangladesh: View Point of Media Reporting.

The negative impact of COVID-19 on mental health has been reported by media throughout the world, although this role is not well-understood in low-and middle-income countries (LMIC). We examined the reporting of mental health issues during the COVID-19 pandemic in Bangladesh and initiatives undertaken to support mental health reported from the viewpoint of media. We reviewed articles published in 10 local newspapers, including seven Bangla and three English newspapers, during the first year of the COVID-19 pandemic.

Well-designed oxidized Sb/g-CN 2D/2D nanosheets heterojunction with enhanced visible-light photocatalytic disinfection activity.

2D/2D heterojunction photocatalysts with excellent photocatalytic activity highlight considerable potential in water disinfection. Here, an oxidized Sb/g-CN 2D/2D nanosheets heterojunction (Sb-SbO/CNS) was constructed based on a facile one-step liquid-phase exfoliation method using concentrated sulfuric acid. By doing so, bulk Sb and g-CN were exfoliated simultaneously and then, intercalated each other.

Domestic Violence and Mental Health During the COVID-19 Pandemic in Bangladesh.

Background: The COVID-19 lockdown, the advent of working from home, and other unprecedent events have resulted in multilayer and multidimensional impacts on our personal, social, and occupational lives. Mental health conditions are deteriorating, financial crises are increasing in prevalence, and the need to stay at home has resulted in the increased prevalence of domestic violence. In Bangladesh, where domestic violence is already prevalent, the lockdown period and stay-at-home orders could result in more opportunities and increased scope for perpetrators of domestic violence.

InO/oxygen doped g-CN towards photocatalytic BPA degradation: Balance of oxygen between metal oxides and doped g-CN.

Hybrid semi-conductor heterojunction appears to be a promising technology for pollutant removal and wastewater treatment. However, the interface modification of the heterojunction and the working mechanisms remain elusive, thus impeding the development of highly efficient photocatalysis. In this work, we highlighted the key role played by the 3D/2D InO/oxygen doped graphitic carbon nitrides (g-CN) heterojunction, named InO/OGCN, on the photocatalytic performance.