A two-tier optimization strategy for feature selection in robust adversarial attack mitigation on internet of things network security.

Adversarial attacks were commonly considered in computer vision (CV), but their effect on network security apps rests in the field of open investigation. As IoT, AI, and 5G endure to unite and understand the potential of Industry 4.0, security events and incidents on IoT systems have been enlarged.

Connectome-based schizophrenia prediction using structural connectivity - Deep Graph Neural Network(sc-DGNN).

Background: Connectome is understanding the complex organization of the human brain's structural and functional connectivity is essential for gaining insights into cognitive processes and disorders.

Objective: To improve the prediction accuracy of brain disorder issues, the current study investigates dysconnected subnetworks and graph structures associated with schizophrenia.

Method: By using the proposed structural connectivity-deep graph neural network (sc-DGNN) model and compared with machine learning (ML) and deep learning (DL) models.

Subsequent infection differentially affects the proteome of Caenorhabditis elegans by abrogating the intestinal cell proliferation.

With a wide range of bacterial infections growing, it has become a big challenge to the research field to combat the newly emerging diseases. Immuno-compromised patients are vulnerable to opportunistic infections. P.

Fentanyl-Induced Respiratory Depression: A Narrative Review on the Possible Single-Nucleotide Polymorphism.

Opioid-related respiratory depression is a serious clinical problem as it can cause multiple deaths and anoxic brain injury. Genetic variations influence the safety and clinical efficacy of fentanyl. Pharmacogenetic studies help in identifying single-nucleotide polymorphisms (SNPs) associated with fentanyl causing respiratory depression and aid clinician in personalized pain medicine.

Significance of probiotics in remodeling the gut consortium to enhance the immunity of Caenorhabditis elegans.

In the recent past, Caenorhabditis elegans has emerged as one of the leading nematode models for studying host-microbe interactions on molecular, cellular, or organismal levels. In general, morphological and functional similarities of the gut of C. elegans with respect to that of human has brought in speculations on the study of the intestinal microbiota.

Dissecting the transactivation domain (tAD) of the transcription factor c-Myb to assess recent models of tAD function.

Transcription factors use a DNA-binding domain to localize their action and a transactivation domain (tAD) to stimulate activation of the associated gene. Recent work has renewed interest in how tADs activate genes, which remains poorly understood. Key features in the new models are exposure of short linear motifs (SLMs) and liquid-liquid phase separation (LLPS).

Graph theoretical analysis, in silico modeling, prediction of toxicity, metabolism and synthesis of novel 2-(methyl/phenyl)-3-(4-(5-substituted-1,3,4-oxadiazol-2-yl) phenyl) quinazolin-4(3H)-ones as NMDA receptor inhibitor.

Hit, Lead & Candidate Discovery A variety of novel 2-(methyl/phenyl)-3-(4-(5-substituted-1,3,4-oxadiazol-2-yl)phenyl) quinazolin-4(3H)-ones have been synthesized by treating 3-(4-(5-mercapto-1,3,4-oxadiazol-2-yl)phenyl)-2-(methyl/phenyl)-quinazolin-4(3H)-one with a variety of secondary amines. Graph theoretical analysis was used in identification of drug target that is, NMDAR (N-methyl-d-aspartate receptors). The observed reports of in silico modeling and ligand based toxicity, metabolism prediction studies were encouraging us to synthesize of title compounds and evaluate their antiepileptic effects.

Comparison of Efficacy of Bupivacaine with Dexmedetomidine Versus Bupivacaine Alone for Transversus Abdominis Plane Block for Post-operative Analgesia in Patients Undergoing Elective Caesarean Section.

Background: Increasing rate of Caesarean sections and inadequate pain relief following Caesarean section is seen in almost all parts of the world. Transversus abdominis plane block is gaining popularity as a part of multimodal analgesia for post-operative pain relief following abdominal surgeries.

Aim: To compare bupivacaine and bupivacaine with dexmedetomidine in transversus abdominis plane block for pain relief after Caesarean section.

Glucocorticoid usage in giant cell arteritis over six decades (1950 to 2009).

Objectives: To evaluate the trends in glucocorticoid (GC) therapy in patients with giant cell arteritis (GCA).

Methods: Using a population-based inception cohort, GC therapy details were collected for all patients with GCA diagnosed between 1950-2009. GC usage for patients diagnosed with GCA between 1980-2009 was compared to those diagnosed between 1950-1979.

The incidence of giant cell arteritis in Olmsted County, Minnesota, over a 60-year period 1950-2009.

Objective: To assess the incidence of giant cell arteritis (GCA) in the era from 2000 to 2009.

Method: We extended the previously identified population-based cohort of Olmsted County, Minnesota residents who fulfilled 1990 American College of Rheumatology (ACR) criteria for GCA for earlier decades during 1950-1999.

Results: In 2000-2009, 74 cases of GCA were identified (mean age 78.

Hospitalized infections in giant cell arteritis: a population-based retrospective cohort study.

Objective: To assess the occurrence of infections requiring or acquired during hospitalization in patients with giant cell arteritis (GCA).

Methods: We retrospectively reviewed a population-based incidence cohort of patients with GCA diagnosed between 1950 and 2009 and compared this cohort with a non-GCA one matched for age, sex, and calendar year from the same population.

Results: We identified 245 patients in the GCA cohort and 245 patients in the non-GCA cohort.

Immunology of oral candidiasis.

A successful pathogen is one that is able to effectively survive and evade detection by the host immune defense. Oral candidiasis has adopted strategies, which evade host defense and eventually cause disease in at-risk patients. Host defense against infections with Candida spp.

Cardiovascular risk and acute coronary syndrome in giant cell arteritis: a population-based retrospective cohort study.

Objective: To assess the occurrence of acute coronary syndrome (ACS) in patients with giant cell arteritis (GCA) compared to subjects without GCA.

Methods: We retrospectively reviewed a population-based incidence cohort of Olmsted County, Minnesota residents with GCA diagnosed in 1950-2009. We compared this cohort with a cohort of patients without GCA of similar age, sex, and calendar year from the same population.

Ex-utero intrapartum treatment in the Indian scenario: Anesthetic challenges and positioning.

Ex-utero intrapartum treatment (EXIT) is performed for fetuses diagnosed with large neck masses. A case report of a fetus diagnosed with a large cystic hygroma and cord around the neck who was delivered by EXIT is presented. The airway challenges and optimal positioning is discussed.

Role of newer imaging modalities for airway assessment in dynamic tracheal compression.

Anesthetic management of a patient with tracheal stenosis is challenging. Though we have newer imaging modalities like multislice, three-dimensional computerized tomography, virtual bronchoscopy to determine the size and anatomy of the airway, it is difficult to accurately predict the distensibility of the trachea with the available preoperative tests. With our experience in this case, we believe that newer imaging modalities are just an adjunct in the assessment of the compromised airway in case of dynamic compression.

Occurrence of gout in rheumatoid arthritis: it does happen! A population-based study.

Aim: It has been a popular belief that gout does not typically occur in patients with rheumatoid arthritis (RA). Our aim was to assess the occurrence, prevalence, clinical presentation and possible risk factors for gout in patients with RA.

Patients & Methods: We retrospectively reviewed a population-based incidence cohort of patients who fulfilled 1987 ACR criteria for RA between 1980 and 2007.

Occurrence and effect of lower extremity ulcer in rheumatoid arthritis -- a population-based Study.

Objective: To assess the occurrence, risk factors, morbidity, and mortality associated with lower extremity (LE) ulcers in patients with rheumatoid arthritis (RA).

Methods: Retrospective review of Olmsted County, Minnesota, USA, residents who first fulfilled the 1987 American College of Rheumatology criteria for RA in 1980-2007 with followup to death, migration, or April 2012. Only LE ulcers that developed after the diagnosis of RA were included.

Concurrent Takayasu arteritis with common variable immunodeficiency and moyamoya disease.

Takayasu arteritis is a rare, chronic form of large vessel vasculitis that characteristically involves the aorta and its branches. Its origin and disease process are currently unknown, although T lymphocytes and, most recently, B cells are thought to play a role. Common variable immunodeficiency (CVID) is a collection of heterogeneous disorders resulting in an antibody deficiency and recurrent infections, and is the most common symptomatic primary immunodeficiency disorder.

Distribution of potentially pathogenic enteric bacteria in coastal sea waters along the Southern Kerala Coast, India.

This study evaluated the relationship between the traditional indicators of faecal pollution, total coliforms (TC), faecal coliforms (FC) and Faecalstreptococci (FS), and the presence of few potentially pathogenic enteric bacteria, Vibrio cholerae (VC), Vibrio parahaemolyticus (VP), Shigella spp. (SH) and Salmonella spp. (SL) in coastal sea water.

Seasonal dynamics of dissolved metals in surface coastal waters of southwest India.

Spatial and temporal variations in concentration of dissolved metals viz. Copper (Cu), Lead (Pb), Chromium (Cr), Nickel (Ni), Zinc (Zn), Cadmium (Cd) and Mercury (Hg) in surface waters of southwest coast of India were studied. Concentrations of metals showed an aberration both temporally and spatially.

Assessment of water quality using principal component analysis--a case study of the Mangalore coastal region, India.

Miscellanies of statistical approaches were employed to illustrate the real picture of quality environmental variables observed in a nationalized monitoring programme. The interpretation and evaluation of the quality data, that was observed, were made very easier by utilizing the wide scope of spectacular statistical software, SPSS 11.0 through the Principal Component Analysis (PCA).

Cutaneous manifestations in patients with chronic renal failure on hemodialysis.

Background: Chronic renal failure (CRF) presents with an array of cutaneous manifestations. Newer changes are being described since the advent of hemodialysis, which prolongs the life expectancy, giving time for these changes to manifest.

Aim: The aim of this study was to evaluate the prevalence of dermatologic problems among patients with chronic renal failure (CRF) undergoing hemodialysis.

Bifid root and root canal in mandibular second premolar and its management--a case report.

Morphogically the mandibular second premolars present one root canal (97.5%). So far only a small percentage (2.