Publications by authors named "Uchewa Obinna"

Background: The Microtubules-associated protein tau (MAPT), alpha-synuclein (SNCA), and leucine zipper tumor suppressor 3 (LZTS3) genes are implicated in neurodegeneration and tumor suppression, respectively. This study investigated the regulatory roles of eugenol on paraquat-altered genes.

Results: Forty male Wistar rats divided into five groups of eight rats were used.

View Article and Find Full Text PDF

The study aims to compare the action of and glibenclamide on alloxan-induced diabetes and ascertain how an aqueous extract of the edible mushroom regulates the expression of nuclear factor erythroid 2-related factor 2 (Nrf2), oxidative stress biomarkers and renal toxicity in a diabetic male Wistar rat model. Twenty-five adult male Wistar rats were randomly grouped into five groups with five rats per. Group 1 and those in the treatment groups received normal feed and water .

View Article and Find Full Text PDF

Background: and honey contain antioxidative, anti-inflammatory, and antimicrobial properties that can help restore neuronal and other cell damage. To investigate the neuromodulatory roles of and honey against lead toxicity on the hippocampus and cerebellum, impairing social behaviors and motor activities.

Methodology: Thirty Wistar rats were separated into six groups of five rats each, marked with dye.

View Article and Find Full Text PDF

Background: Lead without nutritional value is a widely studied occupational and environmental toxicant. Leads' toxic effects on female reproduction are decreased fertility, inability to sustain pregnancy and reduced pregnancy.

Objective: This study aimed at examining the effect of oral administration of lead acetate (1.

View Article and Find Full Text PDF