Herb drug interaction: effect of Manix® on pharmacokinetic parameters of pefloxacin in rat model.

Objective: To evaluate the effect of Manix®, the commonly used polyherbal formulation on pefloxacin pharmacokinetic parameters.

Methods: Microbiological assay was employed using clinical isolate of Escherichia coli samples from hospitalized patients.

Results: Manix® altered the bioavailability parameters of pefloxacin as thus, maximal concentration (Cmax) of pefloxacin (0.