Publications by authors named "Uche S Onuchukwu"
Article Synopsis
- Abnormal growth of neurons and synapses is linked to the lack of Fragile X mental retardation protein (FMRP), but the reasons for increased synaptic protein production aren't fully understood.
- Researchers found that levels of the let-7 microRNA family decrease in FMRP-deficient mice, and this downregulation is no longer triggered by neural activity.
- Restoring let-7 levels in the brain of neonatal mice reversed symptoms of FMRP deficiency, suggesting that targeting let-7 may be a potential strategy for therapy and diagnosis of related disorders.
