Interaction of Vitamin D-BODIPY With Fat Cells and the Link to Obesity-associated Vitamin D Deficiency.

Background/aim: Obese individuals often exhibit vitamin D deficiency, potentially due to sequestration in fat cells. Little is known about how vitamin D enters adipocytes and associates with the intracellular lipid droplet.

Materials And Methods: Newly differentiated human and mouse (3T3-L1) adipocytes and primary mouse adipocytes were treated with vitamin D covalently linked to green fluorescent BODIPY (VitD-B) or Green BODIPY (GB) as control.

Management of the Axilla After Neoadjuvant Chemotherapy: Can Axillary Needle Biopsy Replace Sentinel Node Biopsy?

Background/aim: The aim of the study was to investigate whether it is possible to evaluate the axilla after treatment without performing sentinel lymph node biopsy (SLNB) in breast cancer patients with biopsy-proven axillary lymph node metastases who received neoadjuvant chemotherapy (NAC).

Patients And Methods: This prospective, randomized, clinically designed study included patients with clinical T and biopsy-proven N breast cancer. Prior to the surgery scheduled after NAC, the patients were randomized into two groups.

Obesity prevalence, nutritional status, and physical activity levels in Turkish adults during the COVID-19 pandemic.

Background: Although nutritional status is influenced by multidimensional aspects encompassing physical factors, there is limited research on this complex relationship.

Objectives: This study aimed to examine the interaction between physical activity level indicators and the nutritional status of adults in Türkiye.

Methods: A total of 3,970 individuals aged 18 years or older, residing in Afyonkarahisar (Türkiye), participated in this study.

Differentiation of Malignancy and Idiopathic Granulomatous Mastitis Presenting as Non-mass Lesions on MRI: Radiological, Clinical, Radiomics, and Clinical-Radiomics Models.

Rationale And Objectives: To investigate the effectiveness of machine learning-based clinical, radiomics, and combined models in differentiating idiopathic granulomatous mastitis (IGM) from malignancy, both presenting as non-mass enhancement (NME) lesions on magnetic resonance imaging (MRI), and to compare these models with radiological evaluation.

Material And Methods: A total of 178 patients (69 IGM and 109 breast cancer patients) with NME on breast MRI evaluated between March 2018 and April 2022, were included in this two-center study. Age, skin changes, presence of fistula, and abscess were recorded from hospital records.

Ewing sarcoma of the mandible: A rare case report and literature review.

Ewing sarcoma (ES) usually arises from long bones and affects the head and neck region in only 1%-4% of cases. We reported clinical, radiographic, cytomorphologic, and histomorphologic findings of the ES in the mandible, because of its rarity and radiologically misinterpreted as a parotid gland tumor. A 26-year-old male patient presented with a history of painfull cheek swelling.

Post-Vaccination Detection of SARS-CoV-2 Antibody Response with Magnetic Nanoparticle-Based Electrochemical Biosensor System.

Here, we report magnetic nanoparticle-based biosensor platforms for the rapid detection of SARS-CoV-2 antibody responses in human serum. The use of the proposed system enabled the detection of anti-SARS-CoV-2 spike (S) and nucleocapsid (N) proteins at a concentration of ng/mL in both buffer and real serum samples. In particular, the protocol, which is considered an indicator of innate immunity after vaccination or post-infection, could be useful for the evaluation of antibody response.

The effect of neuromuscular electrical stimulation applied at different muscle lengths on muscle architecture and sarcomere morphology in rats.

Neuromuscular electrical stimulation (NMES) is often used to increase muscle strength and functionality. Muscle architecture is important for the skeletal muscle functionality. The aim of this study was to investigate the effects of NMES applied at different muscle lengths on skeletal muscle architecture.

Vitamin D-Related Risk Factors for Maternal Morbidity and Mortality during Pregnancy: Systematic Review and Meta-Analysis.

Vitamin D deficiency (serum 25-hydroxyvitamin D [25(OH)D] levels <20 ng/mL in serum) is a common health condition among pregnant women, especially in high-risk groups. Evidence has connected vitamin D levels with many health-related problems during pregnancy, including gestational diabetes and preeclampsia. Because of vitamin D’s effect on both mother and fetus, we systematically review the association between 25(OH)D level and its health effects.

Vitamin D-Related Risk Factors for Maternal Morbidity during Pregnancy: A Systematic Review.

Vitamin D has well-defined classical functions related to metabolism and bone health but also has non-classical effects that may influence pregnancy. Maternal morbidity remains a significant health care concern worldwide, despite efforts to improve maternal health. Nutritional deficiencies of vitamin D during pregnancy are related to adverse pregnancy outcomes, but the evidence base is difficult to navigate.

Magnetic resonance imaging findings associated with recurrence in idiopathic granulomatous mastitis.

Purpose: To evaluate magnetic resonance imaging (MRI) findings related to recurrence of idiopathic granulomatous mastitis (IGM).

Methods: Demographic data [age, number of births, duration of lactation period, body mass index (BMI) and presence of recurrence] of 71 patients who were diagnosed with IGM were analyzed retrospectively. Characteristics of IGM (maximum width, location, involvement of the retroareolar region, deep tissue, skin), fibroglandular density (FGD), background parenchymal enhancement (BPE), distribution and pattern of contrast enhancement, presence of prepectoral edema, abscesses, fistulae, axillary lymphadenopathies on MRI and apparent diffusion coefficient (ADC) values from the pathological area were recorded.

MRI Radiomics of Breast Cancer: Machine Learning-Based Prediction of Lymphovascular Invasion Status.

Rationale And Objectives: In patients with breast cancer (BC), lymphovascular invasion (LVI) status is considered an important prognostic factor. We aimed to develop machine learning (ML)-based radiomics models for the prediction of LVI status in patients with BC, using preoperative MRI images.

Materials And Methods: This retrospective study included patients with BC with known LVI status and preoperative MRI.

Validation of a Knowledge Test in Turkish Patients on Warfarin Therapy at an Ambulatory Anticoagulation Clinic.

Objectives: This study aimed to evaluate the validity and reliability of an oral anticoagulation knowledge (OAK) test in Turkish patients on warfarin therapy at an anticoagulant outpatient clinic.

Materials And Methods: This study was conducted at an ambulatory anticoagulation clinic and included patients older than 18 years who had been using warfarin for at least six months. Patients' demographic and clinical data were collected.

A Systematic Review of the Association between Parenting Styles and Narcissism in Young Adults: From Baumrind's Perspective.

The concept 'parenting styles' has been widely examined to understand the etiology of narcissism for decades. This study aimed to systematically review the empirical research literature regarding the association between perceived parenting styles and narcissism. In this study, Ebscohost, Wiley Online Library, Taylor&Francis, Springer Link, PubMed, PsycNet, ScienceDirect, and Google Scholar databases were searched using identified keywords.

Comparison of the efficiency of systemic therapy and intralesional steroid administration in the treatment of idiopathic granulomatous Mastitis. The novel treatment for Granulomatous Mastitis.

Background: Idiopathic granulomatous mastitis that has not had a clear consensus about its treatment since the day it was identified as a rare, benign inflammatory breast disease that mimics malignancy due to its appearance features.

Aims: In our research, we intended to compare the efficiency of intralesional and systemic steroids administration in the treatment of idiopathic granulomatous mastitis.

Study Design: Prospective randomized controlled study.

Characterization of Suspicious Microcalcifications on Mammography Using 2D Shear-Wave Elastography.

Our aim was to investigate the correlations between the findings of two-dimensional shear-wave elastography (2D-SWE) and the histopathologic results of microcalcifications (MCs) visualized using ultrasonography (USG). Fifty people with suspicious MCs without accompanying mass were evaluated. They underwent USG and 2D-SWE before USG-guided tru-cut biopsy.

Radioproteomics in Breast Cancer: Prediction of Ki-67 Expression With MRI-based Radiomic Models.

Rationale And Objectives: We aimed to investigate the value of magnetic resonance image (MRI)-based radiomics in predicting Ki-67 expression of breast cancer.

Methods: In this retrospective study, 159 lesions from 154 patients were included. Radiomic features were extracted from contrast-enhanced T1-weighted MRI (C+MRI) and apparent diffusion coefficient (ADC) maps, with open-source software.

Assessment of Antioxidant Effect of Beta-Glucan on the Whole Blood Oxidative DNA Damage with the Comet Assay in Colorectal Cancer.

Objective: The present study aims to evaluate the antioxidant effect of beta-glucan on oxidative DNA damage by comet assay.

Methods: A total of 19 adult females and males diagnosed with stage 3-4 colorectal cancer and a control group of 20 age-matched healthy subjects were enrolled in the study. Blood samples of the participants were analyzed using Comet Assay for the parameters of DNA damage.

Predictors of discontinuation and hospitalization during long-acting injectable antipsychotic treatment in patients with schizophrenia spectrum disorder.

The aim of this study was to evaluate discontinuation and hospitalization rates in patients with schizophrenia spectrum disorder who were treated with long-acting injectable (LAI) antipsychotics. We recorded clinical data about the period before the LAI treatment, when LAI treatment was initiated, and during the LAI treatment. Variables related to early (<8 weeks) and other LAI discontinuations and hospitalization were analyzed.

How 25(OH)D Levels during Pregnancy Affect Prevalence of Autism in Children: Systematic Review.

Autism spectrum disorder (ASD) is a group of dysfunctions in social interaction, communication, and behaviors. The etiology of ASD is not yet fully understood; however, it consists of the interaction between genetics and the environment. An increasing amount of evidence points to the possibility that gestational and early-childhood vitamin D deficiency may be involved in the etiology of some cases of ASD.

The hospital stressors and depression, anxiety levels in pregnant women hospitalized due to preterm delivery: A follow-up study.

Purpose: To determine the hospital stressors and depression, anxiety levels in pregnant women hospitalized due to preterm delivery.

Design And Methods: This descriptive pretest-posttest study consisted of 147 pregnant women with preterm delivery. Follow-up was performed twice.

Localized Breast Amyloidosis.

Localized amyloidosis in the breast is a very rare disease and may mimic malignant lesions. A 60-year-old woman who had a history of breast-conserving surgery presents with a new a well-defined oval opacity accompanied by many round tight clustered micro- and macrocalcifications on mammograms. It could not be visualized sonographically due to the intense posterior acoustic shadowing of the fat necrosis areas and contrast enhancement was not detected in this area on the dynamic contrast enhanced magnetic resonance images.

Diffusion-Weighted Imaging for the Discrimination of Benign and Malignant Breast Masses; Utility of ADC and Relative ADC.

Purpose: To determine the contribution of apparent diffusion coefficient (ADC), and relative ADC (rADC) values to differentiate between benign and malignant breast masses.

Materials And Methods: Magnetic resonance imaging (MRI) of the breast with diffusion-weighted imaging (DWI) of patients with benign or malignant breast masses diagnosed either by histopathological findings or by follow-up imaging were evaluated retrospectively. Histopathological analyses were performed for 71 lesions (80.

The correlation between biological activity and diffusion-weighted MR imaging and ADC value in cases with prostate cancer.

Purpose: Firstly, we aimed to investigate the correlation among dynamic contrasted magnetic resonance (MR) images, diffusion-weighted MR images, and apparent diffusion coefficent (ADC) values in patients with prostate cancer. Secondly, we aimed to investigate the roles of these variables on clinical risk classification and the biological behavior of the prostate cancer.

Methods: A total of sixty with prostatic adenocarcinoma patients diagnosed between January 2011 and May 2013 were retrospectively included in the study.

Resection of endobronchial hamartoma causing recurrent hemoptysis by electrocautery and cryotherapy.

Background: Pulmonary hamartomas are rare benign tumors of the lung with an incidence of 0.025%-0.32%.

Effectiveness of additional diagnostic parameters in magnetic resonance mammography: a comparative study with the BI-RADS classification and scoring system.

Objective: This study aims to evaluate the strength of magnetic resonance (MR) lesion descriptors for malignancy and to determine the effectiveness of a scoring system that combines BI-RADS parameters with additional criteria.

Materials And Methods: Three hundred thirty-nine histopathologically proven lesions that had undergone MR imaging were analyzed retrospectively. Based on the Fischer scoring system, an optimal cutoff value was calculated for combined parameters.