CRP deposition in human abdominal aortic aneurysm is associated with transcriptome alterations toward aneurysmal pathogenesis: insights from spatial whole transcriptomic analysis.

Background: We investigated the effects of C-reactive protein (CRP) deposition on the vessel walls in abdominal aortic aneurysm (AAA) by analyzing spatially resolved changes in gene expression. Our aim was to elucidate the pathways that contribute to disease progression.

Methods: AAA specimens from surgically resected formalin-fixed paraffin-embedded tissues were categorized into the AAA-high CRP [serum CRP ≥ 0.

The Significance of Detecting an Unusual Myeloblast Immunophenotype in a Presumptive Clinical Diagnosis of Myelodysplastic Syndromes.

Context.—: Blasts in myelodysplastic syndromes (MDSs) typically have a primitive myeloid immunophenotype (CD34+CD117+CD13+CD33+HLA-DR+). On rare occasions, blasts were found to be CD34 negative or minimally expressed in a presumptive MDS.

Perception of Internalized Stigma in Parents of Children With Autism Spectrum Disorder: Investigating the Effects of Depression, Anxiety, and Family Functioning.

Introduction Autism spectrum disorder (ASD) is a pervasive neurodevelopmental disorder that impacts communication, behavior, and social interaction. It is well-documented that parents of children with ASD often experience psychiatric conditions like anxiety and depression. Nevertheless, research on the perception of internalized stigma, family functioning, and their interconnections is scarce.

Flexible transmissive colors with enhanced purity and brightness through overlapping multi-cavity resonances.

We demonstrate flexible transmissive structural color filters with enhanced color purity and brightness by exploiting resonance overlap within multiple cavities in penta-layered structures. Using an inverse design method that combines optimization and exhaustive search algorithms, the material choices and layer thicknesses are determined through a loss function based on the CIE XYZ color space, optimizing both color purity and brightness. The resulting color gamut is comparable to standard RGB, as assessed in the CIE xy color space, with luminance (Y from CIE 1931 model) values for the fabricated transmissive RGB colors being 0.

Green synthesized nanoscale zero-valent iron impregnated tea residue biochar efficiently captures metal(loid)s for sustainable water remediation.

Pristine or modified nanoscale zero-valent iron (nZVI) synthesized though conventional chemical reduction have been widely recommended for remediating metal(loid)-contaminated water. However, their eco-friendliness is often challenged with the concomitant bio-toxicity and secondary environmental risks. Alternatively, this study utilized waste tea leaves extract and remaining residue as the reducing agent and pyrolytic matrix to innovatively fabricate a green synthesized nZVI impregnated tea residue biochar (G-nZVI/TB).

Mechanically processed, vacuum- and etch-free fabrication of metal-wire-embedded microtrenches interconnected by semiconductor nanowires for flexible bending-sensitive optoelectronic sensors.

We demonstrate the facile fabrication of metal-wire-embedded microtrenches interconnected with semiconducting ZnO nanowires (ZNWs) through the continuous mechanical machining of micrograting trenches, the mechanical embedding of solution-processable metal wires therein, and the metal-mediated hydrothermal growth of ZNWs selectively thereto. The entire process can be performed at room or a very low temperature without resorting to vacuum, lithography, and etching steps, thereby enabling the use of flexible polymer substrates of scalable sizes. We optimize the fabrication procedure and resulting structural characteristics of this nanowire-interconnected flexible trench-embedded electrode (NIFTEE) architecture.

Comparing three-dimensional zero echo time (3D-ZTE) lung MRI and chest CT in the evaluation of systemic sclerosis-related interstitial lung disease.

Objective: Systemic sclerosis (SSc) is a chronic disease that can cause interstitial lung disease (ILD), a poor prognostic factor in SSc patients. Given the concerns over radiation exposure from repeated CT scans, there is a growing interest in exploring radiation-free imaging alternatives like MRI for ILD evaluation. The aim of this study is to assess the efficacy of three-dimensional zero echo time (3D-ZTE) MRI in assessing SSc-related ILD compared to the thin-slice chest CT.

Cardiac arrest after spinal anesthesia.

This letter addresses potential cardiovascular changes following spinal anesthesia. High spinal anesthesia with a T4 sensory blockade can lead to decreased venous return, reduced right atrial pressure, and bradycardia. These effects result from diminished sympathetic activity, increased parasympathetic activity, and inhibition of cardiac accelerator fibers.

Cyclin D1-negative mantle cell lymphoma.

Cyclin D1-negative mantle cell lymphoma (MCL) is regarded as a B-cell neoplasm that has morphologic and immunophenotypic findings indistinguishable from typical MCL. These neoplasms lack cyclin D1 overexpression by immunohistochemistry and t(11;14)(q13;q32)/IGH::CCND1. Since cyclin D1-negative MCL was first recognized by gene expression profiling in 2003, there has been diagnostic confusion regarding this entity, mostly attributable to a lack of diagnostic tools to recognize these neoplasms in most clinical laboratories.

Tailoring resonant modes in dual cavities for transmissive structural colors with high brightness and high purity.

We present quad-layered structural color filters producing transmissive red (R), green (G), and blue (B) colors with high brightness and high purity, where thicknesses of layers for the RGB colors are optimized by using a L-BFGS-B algorithm. To evaluate the performance of the proposed structural color filters, computer-based inverse designs based on meta-heuristic and reinforcement learning algorithms are employed, where the optical properties obtained from the inverse designs are comparable to those shown in our proposed design. A peak separation phenomenon in dual cavities is applied to make a spectral response rectangular, and also a resonance order is optimally tailored to maximize the transmittance at a resonant wavelength with the suppression of undesired higher-order resonances at the same time for achieving pure colors.

Characterization and Antibacterial Activity of Silver Nanoparticles Synthesized from (Grasshopper) Extract.

In this study, silver nanoparticles (AgNPs) were synthesized using a green method from an extract of the edible insect (O_extract). The formation of AgNPs (O_AgNPs) was confirmed via UV-vis spectroscopy, and their stability was assessed using Turbiscan analysis. The size and morphology of the synthesized particles were characterized using transmission electron microscopy and field-emission scanning electron microscopy.

Inadvertent Detachment of Stent Retrievers: Report of 2 Cases.

Mechanical thrombectomy using a stent retriever is a widely-used technique for recanalizing occluded cerebral arteries in acute ischemic stroke. Although rare, inadvertent stent detachment has primarily been reported with earlier stent retriever designs. We present 2 cases of inadvertent stent detachment with the pRESET stent.

Efficient removal of nanoplastics by iron-modified biochar: Understanding the removal mechanisms.

Tiny plastic particles, particularly nanoplastics, are becoming major threats to aquatic and biotic life owing to their unique physico-chemical characteristics. Thus, in the present work, biochar (BC) was fabricated using "Ulva prolifera green tide" as a biowaste raw material by slow pyrolysis technique to examine its potential in removing nanoplastics from the environment. The findings depicted that nanoplastics removal efficiency by BC was V-shaped with initial pH increased from 2 to 11, and the main removal mechanism changed from adsorption to heterogeneous aggregation between nanoplastics, biochar colloids, and leached substances from BC.

Achieving the sustainable waste management of medical plastic packaging using a life cycle assessment approach.

Hospital waste management often classifies all waste, including uncontaminated plastic packaging, as hazardous, leading to incineration as the primary treatment method. While effective for safe treatment, incineration incurs high costs and significant environmental impacts. This study explores an alternative approach through the segregation and sustainable management of plastic packaging waste derived from medical device use to mitigate these environmental consequences.