Elucidation of genetic diversity in hawthorn (Crataegus azarolus L.) accessions naturally growing in the Eastern Mediterranean region of Türkiye using morphological, pomological, and inter simple sequence repeat markers.

Background: Türkiye hosts many important fruit species due to its geographical location and ecology. Hawthorn, which is highly beneficial for human health, is one of these significant fruit species. In the present study, 125 accessions of Crataegus azarolus L.

Genome-wide discovery of underlying genetic factors associated with fresh and frozen-thawed semen traits in composite ram breeds exhibiting different cryotolerance.

Fewer studies investigate the effects of underlying genetic factors related to semen characteristics, significantly affecting sheep farm profitability. This study aimed to identify single nucleotide polymorphisms (SNP) and genomic regions associated with fresh and frozen-thawed semen traits in rams with low (Hasak) and high (Hasmer) cryotolerance. Semen collected from 11 (5 Hasak with low and 6 Hasmer with high cryotolerance) rams cryopreserved in 0.

Assessing body awareness and upper extremity functionality in breast cancer survivors with and without lymphedema: a comparative analysis with healthy controls.

Purpose: To determine whether body awareness and upper extremity functionality are affected in patients with or without lymphedema development after breast cancer surgery (BCS) in comparison with individuals without a history of cancer.

Methods: The study included a total of 102 individuals, including 34 who developed lymphedema after BCS (mean age: 43.88 ± 12.

Alexithymia, Anger, Sensitivity to Mild Bodily Sensations and Personality Characteristics of Restless Legs Syndrome Patients: A Case-control Study.

Objective: This study aims to asess alexithymia, anger and its expression, sensitivity to bodily sensations, personality, and their relationship with the severity of the disease in patients with Restless Legs Syndrome.

Method: The study included 63 patients diagnosed with Restless Legs Syndrome and 63 age, gender and education matched controls. All participants were given, Toronto Alexithymia Scale, Somatosensory Amplification Scale, The State Trait Anger Scale and Temperament and Character Inventory.

Human longevity and Alzheimer's disease variants act via microglia and oligodendrocyte gene networks.

Ageing underlies functional decline of the brain and is the primary risk factor for several neurodegenerative conditions, including Alzheimer's disease (AD). However, the molecular mechanisms that cause functional decline of the brain during ageing, and how these contribute to AD pathogenesis, are not well understood. The objective of this study was to identify biological processes that are altered during ageing in the hippocampus and that modify Ad risk and lifespan, and then to identify putative gene drivers of these programmes.

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Using Natural Language Processing and Social Media Data to Understand the Lived Experience of People with Fibromyalgia.

Background And Objectives: Fibromyalgia has many unmet needs relating to treatment, and the delivery of effective and evidence-based healthcare is lacking. We analyzed social media conversations to understand the patients' perspectives on the lived experience of fibromyalgia, factors reported to trigger flares of pain, and the treatments being discussed, identifying barriers and opportunities to improve healthcare delivery.

Methods: A non-interventional retrospective analysis accessed detail-rich conversations about fibromyalgia patients' experiences with 714,000 documents, including a fibromyalgia language tag, which were curated between May 2019 and April 2021.

Comprehensive Analysis of Elemental and Metabolite Composition in Boraginaceae Species from Türkiye.

Boraginaceae plants, including four endemic species from Türkiye, were analyzed for organic and inorganic compositions using ICP-MS and LC-MS/MS to explore their nutritional, medicinal, and ecological significance. This study examined 18 species, identifying key elements such as sodium (87,600.359-118,049.

Digital Ulcers and Microvascular Abnormalities Presenting As the Initial Manifestations of Pre-scleroderma.

The term Raynaud's phenomenon (RP) is used to describe complex symptoms related to vascular compromise, which are typically exacerbated by cold-induced vasoconstriction, emotional stress, or other sympathomimetic factors. In almost all patients with limited cutaneous systemic sclerosis (SSc), the first symptom is RP, often two to five years before any other symptom of scleroderma. The clinical course and severity of this disease are variable and highly fatal in some individuals, which has led to the development of strategies for timely diagnosis; hence, criteria for the very early diagnosis of systemic sclerosis have been established.

Role of the Systemic Immune-Inflammation Index and Systemic Immune-Response Index in the Prediction of Adverse Outcomes in Pregnant Women With Antiphospholipid Syndrome.

Problem: This study aims to evaluate the role of the systemic immune-inflammation index (SII) and the systemic immune-response index (SIRI) in predicting adverse perinatal outcomes (APO) in pregnant women with antiphospholipid syndrome (APS).

Methods: This is a retrospective case-control study at the tertiary center, between January 2015 and January 2023. The study included APS cases and a low-risk control group.

Eltrombopag for Treatment of Thrombocytopenia After Autologous Stem Cell Transplantation in Children: Single Center Experience.

Introduction: Thrombocytopenia is a common clinical problem in cancer patients undergoing high-dose chemotherapy and autologous hematopoietic stem cell transplantation (HSCT). It can occur as prolonged isolated thrombocytopenia (PIT) or secondary failure of platelet recovery (SFPR) and may cause potentially fatal bleeding. However, data on the treatment of post-transplant thrombocytopenia is still lacking.

Clinical evaluation of single bond universal adhesive in non-carious cervical lesions: a 36-month retrospective study.

Objective: To evaluate the 36-month clinical performance of Single Bond Universal Adhesive (SBU; 3M ESPE, Germany) in non-carious cervical lesions (NCCLs) using different modes of adhesion according to the FDI criteria. The primary outcome was the retention loss of the restorations, while the secondary outcomes included marginal staining, marginal adaptation, post-operative sensitivity and tooth vitality, recurrence of caries erosion and abfraction, and tooth integrity, all evaluated according to the FDI criteria.

Materials And Methods: In this study, the SBU Adhesive was applied to 246 NCCLs of 25 patients using different modes of adhesion: Self-etch (SE), selective-enamel-etching (SLE), and etch-and-rinse (ER).

Analysis of ROMO1 Expression Levels and Its Oncogenic Role in Gastrointestinal Tract Cancers.

Gastrointestinal tract cancers account for approximately one-third of cancer-related deaths. Early diagnosis and effective treatment are the most important ways to prevent cancer-related morbidity and mortality. ROMO1 has been shown to play an important role in many types of cancer.

Effects of diabetes mellitus and cervical changes on scar healing after cesarean section.

Aim: This study aimed to evaluate the effects of diabetes mellitus and cervical dilatation on cesarean section scar healing.

Material And Methods: This prospective study included pregnant women diagnosed with diabetes mellitus and healthy control pregnant women. The study group was divided into active labor and pre-active labor based on cervical dilatation, and the diabetic group was categorized into gestational diabetes and preexisting diabetes mellitus.

Investigating the effects of pressure support ventilation and positive end-expiratory pressure during extubation on respiratory system complications.

Background: Postoperative extubation is a critical phase. Various medications and different ventilation modes are employed during extubation to minimize potential issues. This study aimed to observe the early effects of the concurrent use of positive end-expiratory pressure (PEEP) and pressure support ventilation (PSV) modes during the extubation-emerge period on the respiratory system.

Investigation of growth traits in Turkish Merino lambs using multi-locus GWAS approaches: Middle Anatolian Merino.

This study explored the genetic basis of growth traits in Middle Anatolian Merino lambs using multi-locus genome-wide association study (GWAS) analyses. Descriptive statistics indicated moderate heritability (h² = 0.363) for birth weight (BW) and (h² = 0.

Evaluation of the color stability of resin composites subjected to artificial aging procedures: immersion in different solutions, brushing, and thermal cycling.

The aim of this in vitro study was to evaluate the color change of resin composites with different filler contents subjected to immersion in different solutions, brushing, and thermal aging procedures. A total of 320 samples were prepared using 4 different flowable and 4 different conventional resin composites (n = 40). The samples were separated into 4 subgroups according to the solution to be used (wine, coffee, tea, or distilled water) and then immersed in the solutions for 12 days.

Dicle University Hospital's hospital disaster plan and emergency service management: Kahramanmaraş earthquake experience.

Background: Hospitals, being establishments with varying functions and capacities, must have disaster plans that reduce vulnerability, ensure the continuity, and possibly increase the capacity of healthcare services; these measures are crucial for reducing mortality and facilitating the normalization of life after a disaster. In this study, the aim was to analyze the operational process of the disaster management plan at Dicle University Faculty of Medicine Hospital following the earthquake in Kahramanmaraş on 6 February 2023.

Methods: This is a retrospective observational study.

Clinical evaluation, diagnosis, and decision-making for metastatic spine tumors: WFNS spine committee recommendations.

Introduction: Spinal metastases are a significant concern for patients with advanced cancer, leading to pain, neurological deficits, and reduced quality of life. They occur in up to 70% of cancer patients, with the vertebral column being the most common osseous site for metastatic disease. An approximate 10% of patients with vertebral body metastases eventually develop spinal cord compression, which can potentially cause severe and permanent disability.

Evaluation of the Neuroprotective Effects of Idebenone in an Experimental Carbon Monoxide Poisoning Model.

Carbon monoxide (CO) poisoning is among the main causes of poisoning-related mortality and morbidity, primarily affecting the central nervous system and leading to delayed neurological sequelae. Idebenone exerts antioxidant and neuroprotective effects. In this study, we aimed to evaluate the specific neuroprotective effects of idebenone against CO poisoning.

Ontology-based integration and querying of heterogeneous rare disease data sources - POLVAS perspective.

The integration of rare disease medical databases belonging to different countries is an important problem, as a large number of observations are required for reliable statistical inference of patient data in order to facilitate clinical research. Such integration of national registry data, which requires harmonization of the heterogeneous data sets into a unified view, is facilitated in the European FAIRVASC project by developing a domain-specific ontology. The FAIRVASC project is dedicated to the rare disease of anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV).

Evaluation of genetic diversity in some hybrid individuals of honeyberry (Lonicera caerulea L.) based on fruit characteristics, leaf morphology, vitamin C, antioxidant activity, and biochemical and nutritional contents.

Background: Genetic diversity is a prerequisite for breeding programs, and one of the main goals here is to obtain quality products. Therefore, this study aims to evaluate the genetic diversity in some hybrid individuals of honeyberry (Lonicera caerulea L.) based on fruit characteristics, leaf morphology, vitamin C, antioxidant activity, biochemical, and nutritional content.