Publications by authors named "UEkke Karabacak"

Introduction: Gaining clinical judgment competence among student nurses is a significant outcome of nursing education. In this education process, an assessment tool based on observable behaviors is needed for evaluating students' clinical judgment skills.

Objective: This study aimed to evaluate the validity and reliability of the Turkish version of the Lasater Clinical Judgment Rubric, which assesses student nurses' stages of clinical judgment competency in simulation-based education.

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Background/objectives: Glioblastoma (GBM) is the most common malignant primary central nervous system tumor with extremely poor prognosis and survival outcomes. Non-invasive methods like radiomic feature extraction, which assess sub-visual imaging features, provide a potentially powerful tool for distinguishing molecular profiles across groups of patients with GBM. Using consensus clustering of MRI-based radiomic features, this study aims to investigate differential gene expression profiles based on radiomic clusters.

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Background/aim: Cesarean section (CS) is a widely performed operation worldwide but data about uterine closure are lacking. We aimed to evaluate scar niches and compare single-layer and double-layer uterine closure at 6 months following CS.

Materials And Methods: This prospective randomized trial assessed 56 women undergoing single- or double-layer uterine closure.

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Background: This study aimed to evaluate the efficacy and safety of total coronary revascularization via left anterior thoracotomy (TCRAT) by comparing it to conventional coronary artery bypass grafting (CABG) with median sternotomy.

Methods: In this retrospective study, 108 patients (95 males, 13 females; mean age: 57.1±8.

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Background: This study primarily aimed to assess the volumetric attributes of the midbrain and perimesencephalic structures preoperatively and following surgical interventions in patients diagnosed with brain herniation secondary to traumatic brain injury (TBI).

Methods: We evaluated patients based on radiological findings and clinical symptoms indicative of brain herniation. We performed semi-automated segmentation of the intracranial structures most relevant to trauma and of interest for the current study, such as hematoma, ventricles, midbrain, and perimesencephalic cisterns.

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Article Synopsis
  • - This study investigates the relationship between GLP-1 agonists, a type of medication, and the occurrence of pseudarthrosis (a surgical complication) in patients undergoing single-level lumbar fusion surgery.
  • - Data from over 37,000 patients were analyzed, revealing that those who used GLP-1 agonists had significantly lower rates of pseudarthrosis at 6 months, 1 year, and 2 years post-surgery compared to those who did not use these medications.
  • - The findings suggest that GLP-1 agonists may improve spinal fusion outcomes, indicating the need for more research to confirm these results and understand the mechanisms behind this effect.
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Purpose: To assess the impact of the The Controlling Nutritional Status (CONUT) score, an indicator of nutritional status, on the survival and prognosis after radical cystectomy.

Materials And Methods: The medical records of patients who underwent consecutive radical cystectomy operations with the diagnosis of muscle-invasive bladder cancer at our clinic were retrospectively examined. The patients were separated into two groups based on the cut-off CONUT score which was derived using the receiver operating characteristic (ROC) curve.

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  • The study investigates the progression of Behçet's disease when it starts in childhood and how it affects patients in adulthood.
  • Out of 112 pediatric patients, 93 were analyzed, revealing that around 52.5% had major organ involvement, primarily affecting the eyes, with some showing new complications as they transitioned into adulthood.
  • The findings highlight the importance of continued monitoring for these patients, as nearly one-third experienced new symptoms or relapses post-childhood, underscoring the need for regular follow-ups to mitigate potential long-term damage.
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Introduction: Large Language Models (LLMs) are sophisticated algorithms that analyze and generate vast amounts of textual data, mimicking human communication. Notable LLMs include GPT-4o by Open AI, Claude 3.5 Sonnet by Anthropic, and Gemini by Google.

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(1) Background: Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, with an aggressive disease course that requires accurate prognosis for individualized treatment planning. This study aims to develop and evaluate a radiomics-based machine learning (ML) model to estimate overall survival (OS) for patients with GBM using pre-treatment multi-parametric magnetic resonance imaging (MRI). (2) Methods: The MRI data of 865 patients with GBM were assessed, comprising 499 patients from the UPENN-GBM dataset and 366 patients from the UCSF-PDGM dataset.

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Introduction: A patient was presented with a history of idiopathic recurrent anaphylaxis after administration of Pfizer BioNTech mRNA vaccine, and the attacks were controlled with omalizumab. To our knowledge, this is the first reported case of recurrent idiopathic anaphylaxis (IA) after administration of Pfizer BioNTech mRNA vaccine.

Case Presentation: A 52-year-old man with recurrent episodes of IA after COVID-19 vaccination presented to our adult Allergy and Immunology Clinic.

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Intravascular shrapnel or bullet embolization after a gunshot injury is rare, with fewer than 200 cases reported over the past century. Military injuries typically have high energy transfer, making this phenomenon less prevalent. A 22-year-old military personnel presented with chronic leg ischemia resulting from arterial bullet embolization.

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Background Context: Degenerative cervical myelopathy (DCM) is a progressive spinal condition that can lead to severe neurological dysfunction. Despite its degenerative pathophysiology, family history has shown to be a largely important factor in incidence and progression, suggesting that inherent genetic predisposition may play a role in pathophysiology.

Purpose: To determine the tissue-specific, functional genetic basis of hereditary predisposition to cervical myelopathy.

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Article Synopsis
  • Undergraduate medical students often lack hands-on research experience, prompting the Cerrahpasa Neuroscience Society to create a program aimed at enhancing their research skills and encouraging student-led projects.
  • The initiative provided structured training through journal clubs, mentorship, and resource access, allowing 30 volunteer students from various Turkish medical schools to engage in either original research or systematic reviews.
  • As of April 2024, the program resulted in 3 published papers and 3 under peer review, while also increasing student interest in research and self-directed learning.
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Article Synopsis
  • * A total of 4872 features were extracted from various MRI sequences, and LASSO regression helped reduce these features to 176 for model building. Five different machine learning algorithms were tested, with CatBoost performing the best based on various performance metrics.
  • * The results indicate that this radiomics-based approach could allow for non-invasive, pre-operative grading of meningiomas, but more testing on larger datasets is needed to confirm these findings.
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  • * The HWD process involves immersing metal pieces in hot deionized water, allowing zinc oxide molecules to form and deposit on various substrates, including copper and ITO-coated glass.
  • * Results showed the formation of uniformly crystalline ZnO nanorods, making HWD a scalable and inexpensive option for producing metal oxide nanostructures on diverse materials.
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Article Synopsis
  • - Distal medium vessel occlusions (DMVOs) are responsible for 25-40% of acute ischemic stroke cases, but predictive models specifically for DMVO outcomes are not yet available
  • - A retrospective study developed a machine learning model using clinical, lab, imaging, and treatment data from 164 DMVO patients to predict unfavorable outcomes at 90 days, achieving good prediction accuracy and calibration
  • - The model identified key predictive factors like NIHSS score and history of malignancy, and a web application was created for personalized patient outcome predictions, highlighting the potential for better stroke care and personalized medicine.
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Background: Due to significant injury heterogeneity, outcome prediction following traumatic brain injury (TBI) is challenging. This study aimed to develop a simple model for high-accuracy mortality risk prediction after TBI.

Study Design: Data from the American College of Surgeons (ACS) Trauma Quality Program (TQP) from 2019 to 2021 was used to develop a summary score based on age, the Glasgow Coma Scale (GCS) component subscores, and pupillary reactivity data.

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  • Atrial fibrillation (AF) is often triggered by atrial premature complexes (APCs) during exercise, and this study aims to understand their relationship through long-term patient follow-up.
  • The research involved 1559 patients without obstructive coronary artery disease, divided into AF (+) and AF (-) groups based on the development of AF over an average follow-up of around 48 months.
  • Findings indicate that older age and the presence of APCs during exercise significantly increase the risk of developing AF, with patients showing APCs having a much lower AF-free survival rate.
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Background: Venous thromboembolism (VTE) is a significant complication in patients with traumatic brain injury (TBI), but the optimal timing of pharmacological prophylaxis in operative cases remains controversial.

Methods: This retrospective study aimed to describe the timing of pharmacological prophylaxis initiation in operative TBI cases, stratified by surgery type, and to report the frequency of worsening postoperative intracranial pathology.

Results: Data from 90 surgical TBI patients were analyzed, revealing that 87.

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Background: Myocardial fibrosis is often detected in patients with hypertrophic cardiomyopathy (HCM), which causes left ventricular (LV) dysfunction and tachyarrhythmias.

Purpose: To evaluate the potential value of a machine learning (ML) approach that uses radiomic features from late gadolinium enhancement (LGE) and cine images for the prediction of ventricular tachyarrhythmia (VT) in patients with HCM.

Material And Methods: Hyperenhancing areas of LV myocardium on LGE images were manually segmented, and the segmentation was propagated to corresponding areas on cine images.

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Article Synopsis
  • The study examines the effectiveness of middle meningeal artery embolization (MMAE) for treating chronic subdural hematomas (cSDH) compared to traditional surgical methods like craniotomy and burr hole evacuation.
  • A systematic literature review analyzed available meta-analyses, finding that MMAE led to fewer reoperations and recurrences, but this was supported by weak evidence.
  • The conclusion highlights a lack of substantial evidence regarding MMAE's benefits over conventional treatments, indicating the need for more research in this area.
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