[Effect of ethionine on intestinal enzymatic activity in adult rats].

The activity of intestinal enzymes (dipeptidase, monoglyceride lipase, amylase, invertase) was studied in intestinal mucosa homogenates from different parts of the small intestine in adult rats 24, 48, and 72 hours after a single intraperitoneal administration of ethionine in a dose of 500 mg/kg bw. 24 hours after antimetabolite administration there was a decrease in the abrasion of the small intestinal mucosa. The enzyme-forming function of the small intestine appreciably changed throughout the observation period.

[Effect of different food stimuli on pancreatic exocrine function in ontogeny].

The fermentative adaptation of the pancreas to the quality of food through determination of the amylase, lipase and proteases activity in the contents of the small intestine and the gland homogenate on an empty stomach and 2 hours feeding on the egg white, bread and walnuts were studied in chickens aged 1-60 days. The 1-2 day old chicken are shown to lack the ability to adapt the gamut of pancreatic enzymes to the quality of the stimulant. This ability appears on the 5th day and becomes persistent by the 20th day of life.

[Exocrine function of the pancreas under the effect of different doses of hexachlorocyclohexane].

Experiments conducted on albino rats poisoned with different doses of hexachlorocyclohexane (HCCH) demonstrated that large doses of this compound (1/3 DL50) following their single introduction were capable of inhibiting the secretion of the amylase, lipase, and proteases of the pancreas. Of a prolonged action of relatively small doses of HCCH (1/20 and 1/50 DL50) is characteristic an initial inhibition and subsequent stimulation of the exosecretory function of the pancreas. A definite inverse relation between the amount of the introduced HCCH dose and the duration of the pancreatic inhibition period was noted.

[Effect of different doses of tetramethylthiuram disulfide on the enzyme-forming function of the small intestine].

The effect of tetramethylthiuramdisulphide on the activity of the small intestine mucosa in rats was studied. When administered in different doses the compound was found to bring about, in the main, a fall of the monoglyceride-lipase and dipeptidase and a rise of the invertase alkaline-phosphatase and amylolytic activity. A protracted introduction of the compound brings down the weight of the small intestine mucosa.