Publications by authors named "U Wyneken"
Article Synopsis
- Pregnant moms who feel stressed can affect the growth and development of their babies, especially in male babies.
- Scientists studied tiny particles called small extracellular vesicles (sEVs) in the mom's blood, which might carry stress signals to the baby.
- The research found that stressed moms had different types of proteins in their sEVs, and these particles seemed to affect the baby's tissues more when the mom was stressed.
Chronic stress can trigger several pathologies including mood disorders for which no clear diagnostic molecular markers have been established yet. Attractive biomarker sources are extracellular vesicles (EVs). Evs are released by cells in health and disease and contain genetic material, proteins and lipids characteristic of the cell state.
View Article and Find Full Text PDFArticle Synopsis
- Fluoxetine is a popular selective serotonin reuptake inhibitor (SSRI) used mainly for treating major depressive disorder and other central nervous system conditions due to its safety and effectiveness.
- The drug's antidepressant effects are well-understood, involving serotonin reuptake inhibition and activation of key brain receptors related to neurotrophic support.
- However, the impact of fluoxetine on cognitive functions is mixed, with some studies showing improvements in patients while others reveal negative effects influenced by factors like gender, age, and treatment duration, highlighting the need for cautious prescribing and more research.
Article Synopsis
- Methadone, a long-acting synthetic opioid used for treating opioid addiction in pregnant women, can negatively affect infants by causing cognitive and behavioral issues due to prenatal exposure.
- Prenatal exposure to methadone has been shown to cause severe central nervous system problems in animal studies, including neuron death, disrupted cell maturation, and increased brain inflammation.
- In laboratory tests, methadone directly harmed brain cells, leading to increased neuron death, decreased synaptic connections, and greater inflammation, indicating a need for better treatment options for opioid addiction during pregnancy.