Publications by authors named "U Williams"
Article Synopsis
- Traumatic brain injury (TBI) is a major cause of disability globally, with complex primary and secondary injury processes involved.
- Microglia, the central nervous system's immune cells, play a critical role in TBI-related inflammation, acting both protectively and harmfully.
- Understanding the timing and mechanisms of microglial activity is essential for creating effective therapies to manage neuroinflammation and enhance recovery from TBI.
Background: Fascial plane blocks (FPBs) are widely used for abdominal surgery with the assumption that liposomal bupivacaine (LB) is more effective than standard bupivacaine (SB).
Methods: This was a single-institution retrospective cohort study of patients administered FPBs with LB or SB + admixtures (dexamethasone/dexmedetomidine) for open abdominal cancer surgery. Propensity score matching generated a 2:1 (LB:SB) matched cohort.
The relationship between APOE polymorphisms and Parkinson's disease (PD) in black Africans has not been previously investigated. We evaluated the association between APOE polymorphic variability and self-declared cognition in 1100 Nigerians with PD and 1097 age-matched healthy controls. Cognition in PD was assessed using the single item cognition question (item 1.
View Article and Find Full Text PDFBackground: Where applicable, regional anesthesia has been shown to be superior to opioid or non-opioid analgesic modalities alone. However, some studies have shown ethnic-based disparities in the use of regional anesthesia in patients undergoing surgical procedures. In this study of patients who had undergone major oncologic surgery, our main objective was to compare the use of regional anesthesia between patients of different ethnicities.
View Article and Find Full Text PDFBackground: Data on non-motor symptoms (NMS) in black Africans with Parkinson's disease (PD) are sparse.
Objective: To describe the profile of NMS in the Nigeria PD Registry (NPDR) cohort and explore the relationship between NMS and PD motor phenotype.
Methods: We conducted a cross-sectional study of the frequency and burden of NMS, based on the non-motor symptoms scale (NMSS) and the Chaudhuri method respectively in our cohort.