Publications by authors named "U Wilkenshoff"
Article Synopsis
- Traditional cardiovascular biomarkers like hsTnT and NT-proBNP are crucial for monitoring cardiac function and prognosis in cancer patients, but newer biomarkers such as MR-proADM, copeptin, and MR-proANP may provide better predictive power.
- A study involving 442 hospitalized cancer patients showed that while several biomarkers predicted all-cause mortality, only MR-proADM remained a significant independent predictor after adjusting for various factors.
- MR-proADM demonstrated the highest predictive accuracy, with a specific cutoff of 0.94 nmol/L signaling a higher risk of mortality, particularly in older patients with advanced cancer stages and poorer overall health.
Background: Growth hormone (GH) resistance is characterized by high GH levels but low levels of insulin-like growth factor-I (IGF-I) and growth hormone binding protein (GHBP) and, for patients with chronic disease, is associated with the development of cachexia.
Objectives: We investigated whether GH resistance is associated with changes in left ventricular (LV) mass (cardiac wasting) in patients with cancer.
Methods: We measured plasma IGF-I, GH, and GHBP in 159 women and 148 men with cancer (83% stage III/IV).
Hand grip strength in patients with advanced cancer: A prospective study.
J Cachexia Sarcopenia Muscle
August 2023
Background: Hand grip strength (HGS) is a widely used functional test for the assessment of strength and functional status in patients with cancer, in particular with cancer cachexia. The aim was to prospectively evaluate the prognostic value of HGS in patients with mostly advanced cancer with and without cachexia and to establish reference values for a European-based population.
Methods: In this prospective study, 333 patients with cancer (85% stage III/IV) and 65 healthy controls of similar age and sex were enrolled.
Background: Maintaining the ability to perform self-care is a critical goal in patients with cancer. We assessed whether the patient-reported ability to walk 4 m and wash oneself predict survival in patients with pre-terminal cancer.
Methods: We performed a prospective observational study on 169 consecutive hospitalized patients with cancer (52% female, 64 ± 12 years) and an estimated 1-12 months prognosis at an academic, inpatient palliative care unit.
Background: Body wasting in patients with cancer can affect the heart.
Objectives: The frequency, extent, and clinical and prognostic importance of cardiac wasting in cancer patients is unknown.
Methods: This study prospectively enrolled 300 patients with mostly advanced, active cancer but without significant cardiovascular disease or infection.