Assessment of biotransformation during transfer of propoxyphene and acetaminophen across the isolated perfused human placenta.

The purpose of this investigation was to assess the extent of biotransformation of drugs by the human placenta during their transfer from the maternal to the fetal circulation. Propoxyphene was used to determine N-demethylation, and acetaminophen served as a substrate for glucuronide and sulfate conjugation. Human full-term placentae were dually perfused in vitro, with one or the other drug being added to the maternal circulation.

[Multiple skin plasmocytomas, increased serum IgA and lack of bone marrow lesions (author's transl)].

Extramedullary plasmocytomas of the skin are rare, especially if a participation of the bone marrow is lacking. A 76-year-old patient developed multiple skin tumours within 2 months. In addition he showed an increase of serum immunoglobulin A.

[A new case of reticular hyperplasia connected with volatile oils].

An additional case of "reticular hyperplasia" is described. The clinical picture is trimorphic with grouped nodules, spinulosismus-like and parapsoriasiform lesions. Histologically there are dense lymphoreticular, partly eosinophilic infiltrates with leucocytoclastic cell aggregates, which, however, do not resemble mycosis fungoides nor a reticulosis.