Comprehensive biomarker and modeling approach to support dose finding for BI 836880, a VEGF/Ang-2 inhibitor.

Background: BI 836880 is a humanized bispecific nanobody® that binds to and blocks vascular endothelial growth factor (VEGF) and angiopoietin-2 (Ang-2). A comprehensive biomarker and modeling approach is presented here that supported dose finding for BI 836880.

Methods: Two Phase I dose-escalation studies (1336.

Plasma-Enabled Process with Single-Atom Catalysts for Sustainable Plastic Waste Transformation.

The escalating issue of plastic waste generation has prompted the search for an effective solution to address these challenges. In this study, we present a novel plasma-enabled strategy for the rapid breakdown of various types of plastic wastes, including mixtures, into high-value carbon nanomaterials and hydrogen. The H yield and selectivity achieved through the implemented catalyst-free plasma-enabled strategy are 14.

A European Bioanalysis Forum recommendation for requiring a context-of-use statement for successful development and validation of biomarker assays.

The European Bioanalysis Forum, alongside key industry stakeholders, has been driving the discussions around the implementation of context-of use for biomarker assays to ensure that these assays are validated appropriately depending on their purpose. Insights into understanding why the implementation of context-of-use in assay strategies has also shown that the key stakeholder, or requester for the biomarker data, is responsible for providing the context-of-use statement for all biomarker assay requests. Experts from across the industry haves repeatedly sought a cross-industry recommended format in which the context-of-use statement could be provided.

Influence of Water Hardness and Complexing Agents on Electrochemical Hydrogen Peroxide Generation.

Recently, many studies have been published regarding electrochemical oxygen reduction reaction for generating hydrogen peroxide (HO) using gas diffusion electrodes (GDEs) for various applications. Sodium salts solved in deionized water were usually used as supporting electrolytes. In technical applications, however, tap water-based electrolytes with hardeners are particularly relevant and have only been considered in a few studies to date.

Investigation of an electrolysis system with boron-doped diamond anode and gas diffusion cathode to remove water micropollutants.

Using electrolysis systems to degrade organics in wastewater encourages this technique to remove micropollutants (MPs) in different types of water. In this work, a cell consisting of an anode as a boron-doped diamond (BDD) electrode combined with a gas diffusion (GDE) cathode without a separator showed that MPs degradation can be effectively achieved. Investigating different operating parameters, it was stated that applying a low current density (2 mA/cm) and setting the Reynolds number of the electrolyte flow through the cell at the laminar range raised the treatment time by 3-fold at the same energy demand.