Publications by authors named "U Sechtem"
Article Synopsis
- Coronary functional disorders (CFD) significantly contribute to angina in patients with non-obstructed coronary arteries (ANOCA), with different endotypes identified, such as microvascular spasm and coronary microvascular dysfunction (CMD).
- A study involving 89 ANOCA patients using comprehensive coronary functional testing (CFT) found that 91% had at least one disorder, with microvascular spasm being the most common (61%).
- The results highlighted that isolated CMD is rare and emphasized the necessity of spasm testing for diagnosing and characterizing CFD in ANOCA patients.
Article Synopsis
- * The research involved 372 patients with angina but non-obstructive coronary arteries, comparing results from those who received RASP vs. those who did not during ACh provocation testing.
- * Findings indicated that RASP did not significantly change the frequency or type of coronary vasomotor responses when tested with ACh, meaning it can be safely used in patients undergoing spasm testing.
Myocardial ischemia is a complex condition which may result from epicardial and/or microvascular causes involving functional and structural mechanisms. These mechanisms may overlap in a given patient illustrating the difficulties for appropriate management. Assessment of myocardial ischemia can be performed using noninvasive and invasive tools.
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- The study investigates the genetic factors contributing to coronary artery spasm (CAS) in European patients with angina and unobstructed coronary arteries, particularly focusing on variants from 208 cardiovascular-related genes.
- Although no findings met the genome-wide significance threshold, suggestive genetic associations were found for focal and diffuse epicardial CAS, particularly relating to genes CDH13 and HDAC9, EDN1 respectively.
- The research suggests that EDN1 may be a potential genetic risk factor for diffuse epicardial CAS, with elevated plasma endothelin-1 levels identified as a possible cardiac marker.
Background: Electrocardiograms (ECGs) recorded with wearable devices and additional smartphone apps play an increasing role in cardiology.
Case Summaries: We present two cases in which it was possible to record an ECG during cardiac-related symptoms using the patients' smartphones. Previous standard resting and 24-hour ECGs had revealed no pathologies.