Publications by authors named "U S Kulkarni"
Background: Severe hemophilia A is managed with factor VIII replacement or hemostatic products that stop or prevent bleeding. Data on gene therapy with hematopoietic stem-cell (HSC)-based expression of factor VIII for the treatment of severe hemophilia A are lacking.
Methods: We conducted a single-center study involving five participants 22 to 41 years of age with severe hemophilia A without factor VIII inhibitors.
Granulocyte transfusions (GTx) combat infections in neutropenic patients. However, immune-mediated off-target effects in transplant settings are unknown. Between January 2020 and December 2021, all transplants that used GTx during the peri-transplant period were analysed.
View Article and Find Full Text PDFFungal Intracranial Infections (Central Nervous System-Invasive Fungal Disease) in Patients With Haematological Disorders-A Single-Centre Retrospective Study.
Mycoses
October 2024
Article Synopsis
- - Invasive fungal disease (IFD) in the central nervous system (CNS) poses a significant risk to patients with hematological disorders, leading to severe outcomes, especially in those undergoing chemotherapy or stem cell transplants.
- - A study analyzed 43 patients diagnosed with CNS-IFD from 2018 to 2022, identifying key clinical signs, such as sudden deterioration in sensorium, along with prevalent infections caused by Rhizopus and Aspergillus species.
- - The study revealed a low overall survival rate of 27.9% within six months, emphasizing the critical need for early diagnosis and timely antifungal treatment to improve patient outcomes.
Total marrow and lymphoid irradiation (TMLI) can deliver higher doses of irradiation without increased toxicity. This study evaluated TMLI and cyclophosphamide in patients undergoing stem cell transplantation for acute lymphoblastic leukemia (ALL). A total of 58 patients underwent matched related, unrelated, or haplo-identical donor transplantation using TMLI.
View Article and Find Full Text PDFArticle Synopsis
- Invasive aspergillosis (IA) is a serious infection affecting patients with blood cancers, and traditional diagnostic methods are challenging.
- A study evaluated the effectiveness of a multiplex real-time PCR test (AsperGenius) against the standard galactomannan test for diagnosing IA in hematology patients, involving 107 participants.
- Results showed that a combined approach using both tests improved the diagnosis of IA, with PCR and galactomannan testing together achieving better sensitivity and specificity than either method alone.