Designing Highly Potent Side-Chain Lactam-Bridged Cyclic Competence-Stimulating Peptide-Based Quorum-Sensing Modulators in .

, a Gram-positive bacterium found in the oral microbiome, shows promise as an oral probiotic for preventing dental caries. It exhibits a reverse correlation with , a key caries-causing pathogen, likely due to its production of hydrogen peroxide, a process mediated by quorum sensing (QS). In this work, we set out to develop novel lactam-based cyclic analogues of the competence stimulating peptide (CSP) signal utilized by for QS activation.

Very broad distribution of β sheet registries of the HIV gp41 fusion peptide supports mutational robustness for fusion and infection.

HIV, like other membrane-enveloped viruses, has protein spikes that include a fusion peptide (Fp) segment that binds the host cell membrane and plays a critical role in fusion (joining) viral and cell membranes. The HIV Fp is the ~23 N-terminal residues of the gp41 spike protein. Fp adopts intermolecular antiparallel β sheet structure when lipid fraction cholesterol ≈0.

Granular memristors with tunable stochasticity.

Most realizations of memristive devices exhibit characteristic noise sometimes described as random telegraph noise. These fluctuations in current, ubiquitous in nature, carry significant implications for device performance, reliability, and the broader landscape of memristor technology applications. Here, we study inherent random fluctuations observed in silver based granular memristive devices operating under steady bias conditions.

USE OF TANTALUM CUP IN TOTAL HIP ARTHROPLASTY-A NARRATIVE REVIEW.

Tantalum, known for its superior mechanical properties and biocompatibility, has revolutionized the field of acetabular reconstruction, especially in revision total hip arthroplasty (rTHA). This review explores the clinical indications, biomechanical and biological properties, benefits, risks, and outcomes associated with tantalum acetabular components, particularly in managing complex cases of acetabular deficiencies. Extensive research has highlighted tantalum's ability to promote osseointegration, provide high survivorship rates, and maintain mechanical stability even in the most challenging cases, such as pelvic discontinuity and severe bone loss.