Publications by authors named "U S Baghel"
Flavopiridol: a promising cyclin-dependent kinase inhibitor in cancer treatment.
Naunyn Schmiedebergs Arch Pharmacol
November 2024
Article Synopsis
- Flavopiridol is a potent CDK inhibitor derived from rohitukine, known for its anticancer effects such as cell cycle arrest and apoptosis, though clinical use is limited by toxicity and drug resistance.
- Its efficacy is influenced by structural modifications, particularly in the D ring, leading to synthetic derivatives that show improved anticancer activity.
- Future research should prioritize enhancing flavopiridol's therapeutic profile, reducing toxicity, and exploring combination therapies, especially with immunotherapy, to overcome resistance in cancer treatment.
Neuroprotective potential of Myrica esulenta in Haloperidol induced Parkinson's disease.
J Ayurveda Integr Med
September 2020
Background: Myrica esculenta is a notable therapeutic plant widely utilized in Indian system of medicine. Ayurvedic literature reported fruit and bark of this plant is used in gulma, jvara, arsa, grahani, pandu roga, hrillasa, mukha roga, kasa, svasa, agnimandhya, aruchi, meha, and kantharoga.
Objective: The present study aimed to investigate the neuroprotective potential of "Himalayan Bayberry" (Myrica esculenta Buch.
: Plant diversity is a basic source of food and medicine for local Himalayan communities. The current study was designed to assess the effect of different solvents (methanol, ethyl acetate, and water) on the phenolic profile, and the corresponding biological activity was studied. : Antioxidant activity was investigated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2″-azino-bis(3-ethylbenzothiazoline-6-sulphonic) acid (ABTS) assay, while the antimicrobial activity was evaluated by disk diffusion method using various bacterial and fungal strains.
View Article and Find Full Text PDF(Myricaceae) is a popular medicinal plant most commonly found in the sub-tropical Himalayas. It is widely used in folk medicine to treat several ailments such as asthma, cough, chronic bronchitis, ulcers, inflammation, anemia, fever, diarrhea, and ear, nose, and throat disorders. Due to its multidimensional pharmacological and therapeutic effects, it is well recognized in the ayurvedic pharmacopeia.
View Article and Find Full Text PDFBackground: Osteoarthritis (OA) ranks fifth among all forms of disability affecting 10% of the world population. Current treatments available are associated with multiple side effects and do not slow down the progression of the disease. Moreover, no such effective treatment is available to date in various systems of medicine to treat osteoarthritis.
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